Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes - Tabular View

This Tabular View shows the required WHO registration data elements as marked by ^†

Tracking Information

First Received Date ^†

July 19, 2007

Last Updated Date

March 20, 2008

Start Date ^†

March 2007

Current Primary Outcome Measures ^†

Performance on memory tasks [ Time Frame: 2 hours after MRI ] [ Designated as safety issue: No ]

Original Primary Outcome Measures ^†

Same as current

Change History

Complete list of historical versions of study NCT00504894 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^†

Original Secondary Outcome Measures ^†

Descriptive Information

Brief Title ^†

Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes

Official Title ^†

Neuroimaging the Effects of Intravenous Anesthetic on Amygdala Dependent Memory Processes

Brief Summary

This study involves 54 healthy volunteers aged between 18 and 50 recruited from the general community. It involves doing a set of simple memory tests while inside a fMRI machine. The subject is given a very low dose of an anesthetic drug intravenously while in the scanner. The subject then sees a sequence of pictures on a screen, and presses a button if they remember seeing the picture before. While this is happening, the scanner will be capturing images that tell us what parts of the brain are active. Hypothesis: patterns of hippocampal and amygdala activation during the encoding and retrieval of memory,as measured by fMRI, will be altered by intravenous anesthetics such that suppression of hippocampal and amygdala activities will be dissociable.

This dissociation pattern will be different between the drugs propofol and thiopental

Detailed Description

Study Phase

Phase IV

Study Type ^†

Interventional

Study Design ^†

Other, Randomized, Single Blind (Subject), Parallel Assignment

Condition ^†

Healthy

Intervention ^†

Drug: Thiopental
Drug: Propofol

Study Arms / Comparison Groups

Placebo Comparator: Drug given in low dose to gauge subject's responses to visual stimuli.
Placebo Comparator: Thiopental administration

Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^†

Recruiting

Enrollment ^†

Completion Date

Estimated Primary Completion Date

December 2010 (final data collection date for primary outcome measure)

Eligibility Criteria ^†

Inclusion Criteria:

age b/w 18 and 50
right-handed
minimum of high school education
fluent in English
normal vocabulary

Exclusion Criteria:

any significant medical/psychiatric comorbidity
deficit in vision or hearing that would impede the study
allergies to any of the study drugs, to soybeans, or eggs.
history of head trauma
family history of major psychiatric illness
body mass index > 30 kg/m2
claustrophobia
prior exposure to IAPS pictures
pregnancy
permanent metal objects anywhere in the body
a personal/family history of any porphyria

Gender

Both

Ages

18 Years to 50 Years

Accepts Healthy Volunteers

Yes

Contacts ^††

Contact: Jackie Bogan, BA	212-746-2952	jab2035@med.cornell.edu
Contact: Kane Pryor, M.D.

Location Countries ^†

United States

Expanded Access Status

Administrative Information

NCT ID ^†

NCT00504894

Responsible Party

Kane Pryor, MD, WCMC

Secondary IDs ^††

Study Sponsor ^†

Weill Medical College of Cornell University

Collaborators ^††

Investigators ^†

Principal Investigator:

Kane Pryor, M.D.

Weill Cornell Medical College

Information Provided By

Weill Medical College of Cornell University

Verification Date

February 2008

^† Required WHO trial registration data element.
^†† WHO trial registration data element that is required only if it exists.