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Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health. EHP is published by the National Institute of Environmental Health Sciences and its content is free online. Print issues are available by paid subscription.DISCLAIMER
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Environmental Health Perspectives Supplements Volume 109, Number S4, August 2001
Environmental Health Perspectives Supplements August 2001 Inhaled Environmental/Occupational Irritants and Allergens: Mechanisms of Cardiovascular and Systemic Responses

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Short-term increases in concentrations of particles and associated pollutants lead to increases in daily morbidity and mortality. Much progress has been made in understanding the mechanisms by which nonrespiratory health effects occur.

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Inhaled Irritants and Allergens

Introduction
Inhaled Environmental/Occupational Irritants and Allergens: Mechanisms of Cardiovascular and Systemic Responses


Donovan B. Yeates and Joe L. Mauderly
p. 479
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Particles, Co-Pollutants, and Mortality and Morbidity

Epidemiologic Evidence of Cardiovascular Effects of Particulate Air Pollution


Douglas W. Dockery
p. 483
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Identification of Persons with Cardiorespiratory Conditions Who Are at Risk of Dying from the Acute Effects of Ambient Air Particles


Mark S. Goldberg, Richard T. Burnett, John C. Bailar III, Robyn Tamblyn, Pierre Ernst, Kenneth Flegel, Jeffrey Brook, Yvette Bonvalot, Ravinder Singh, Marie-France Valois, and Renaud Vincent
p. 487
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Airborne Particulates and Hospital Admissions for Cardiovascular Disease: A Quantitative Review of the Evidence


Robert D. Morris
p. 495
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The Burden of Air Pollution: Impacts among Racial Minorities


R. Charon Gwynn, and George D. Thurston
p. 501
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Human Breathing and Eye Blink Rate Responses to Airborne Chemicals


James C. Walker, Martin Kendal-Reed, Mark J. Utell, and William S. Cain
p. 507
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Cardiovascular Consequences of Inhaled Irritants and Allergens

Bronchial, Alveolar, and Vascular-Induced Anaphylaxis and Irritant-Induced Cardiovascular and Pulmonary Responses


Donovan B. Yeates, Donna J. Mussatto, W. Matt Hameister, Anthony Daza, Tarun Chandra, and Lid B. Wong
p. 513
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Ambient Particle Inhalation and the Cardiovascular System: Potential Mechanisms


Ken Donaldson, Vicki Stone, Anthony Seaton, and William MacNee
p. 523
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Systemic and Cardiovascular Effects of Airway Injury and Inflammation: Ultrafine Particle Exposure in Humans


Mark W. Frampton
p. 529
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Cardiovascular Effects of Air Pollution: What to Measure in ECG?


Wojciech Zareba, Atsunobu Nomura, and Jean Philippe Couderc
p. 533
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Cardiovascular and Systemic Responses to Inhaled Pollutants in Rodents: Effects of Ozone and Particulate Matter


William P. Watkinson, Matthew J. Campen, Julianne P. Nolan, and Daniel L. Costa
p. 539
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Transport of Gases, Molecules, Particles, and Allergens across Epithelia

Pulmonary and Systemic Distribution of Inhaled Ultrafine Silver Particles in Rats


Shinji Takenaka, Erwin Karg, Christa Roth, Holger Schulz, Axel Ziesenis, Ulrich Heinzmann, Peter Schramel, and Joachim Heyder
p. 547
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Allergen-Induced Generation of Mediators in the Mucosa


Sabrina Mattoli
p. 553
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The Direct and Indirect Action of Inhaled Agents on the Lungs and Its Circulation: Lessons for Clinical Science


Tim Higenbottam, Tom Siddons, and Eric Demoncheaux
p. 559
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The Role of the Bronchial Vasculature in Soluble Particle Clearance


Elizabeth M. Wagner and W. Michael Foster
p. 563
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Activation of Neural Pathways by Inhalation of Allergens and Irritants

Inflammation-Induced Plasticity of the Afferent Innervation of the Airways


Michael J. Carr and Bradley J. Undem
p. 567
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Lung C-Fiber CNS Reflex: Role in the Respiratory Consequences of Extended Environmental Tobacco Smoke Exposure in Young Guinea Pigs


A.C. Bonham, C.-Y. Chen, T. Mutoh, and J.P. Joad
p. 573
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Airway Reflexes, Autonomic Function, and Cardiovascular Responses


John Widdicombe and Lu-Yuan Lee
p. 579
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Modulation of Airway Sensitivity to Inhaled Irritants: Role of Inflammatory Mediators


Lu-Yuan Lee and John G. Widdicombe
p. 585
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Pulmonary Target Cells and Their Responses

Effects of Ozone and Endotoxin Coexposure on Rat Airway Epithelium: Potentiation of Toxicant-Induced Alterations


James G. Wagner, Jon A. Hotchkiss, and Jack R. Harkema
p. 591
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Inhalation of PM2.5 Does Not Modulate Host Defense or Immune Parameters in Blood or Lung of Normal Human Subjects


Shirley D. Harder, Joleen M. Soukup, Andrew J. Ghio, Robert B. Devlin, and Susanne Becker
p. 599
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Interactions of Allergens and Irritants in Susceptible Populations in Producing Lung Dysfunction: Implications for Future Research


Annette T. Hastie and Stephen P. Peters
p . 605
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Air Pollution Can Impair Host Defenses

Effect of Exposure to Diesel Exhaust Particles on the Susceptibility of the Lung to Infection


Vincent Castranova, Jane Y.C. Ma, Hui-Min Yang, Jim M. Antonini, Leon Butterworth, Mark W. Barger, Jenny Roberts, and Joseph K.H. Ma
p. 609
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Agglomerates of Ultrafine Particles of Elemental Carbon and TiO2 Induce Generation of Lipid Mediators in Alveolar Macrophages


Ingrid Beck-Speier, Niru Dayal, Erwin Karg, Konrad L. Maier, Christa Roth, Axel Ziesenis, and Joachim Heyder
p. 613
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Air Pollutant-Enhanced Respiratory Disease in Experimental Animals


M. Ian Gilmour, Mary Daniels, Robert C. McCrillis, Darrel Winsett, and MaryJane K. Selgrade
p. 619
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