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Sponsors and Collaborators: |
RWTH Aachen University University of Heidelberg |
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Information provided by: | RWTH Aachen University |
ClinicalTrials.gov Identifier: | NCT00752713 |
The aim of the study was therefore to evaluate whether myocardial deformation imaging performed by SENC allows for quantification of regional left ventricular function and is related to transmurality states of infarcted tissue in patients with acute myocardial infarction (AMI).
Condition | Intervention |
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Acute Myocardial Infarction |
Procedure: cardiac MRI |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Strain-Encoded Magnetic Resonance Imaging for Evaluation of Left Ventricular Function and Acute Myocardial Infarction |
Enrollment: | 48 |
Study Start Date: | January 2007 |
Study Completion Date: | January 2008 |
Primary Completion Date: | January 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
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1
Patients presenting to hospital with AMI
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Procedure: cardiac MRI
cardiac MRI at one time point for group 1 after intervention for group 2 at any time point
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2
healthy volunteers as control group
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Procedure: cardiac MRI
cardiac MRI at one time point for group 1 after intervention for group 2 at any time point
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CMR was performed in 38 consecutive patients with AMI 3±1 days after successful reperfusion using a clinical 1.5 Tesla MR-scanner. Ten healthy volunteers served as controls. SENC is a technique that directly measures peak circumferential strain from long-axis views and peak longitudinal strain from short axis views. Measurements were obtained for each segment in a modified 17 segment model. Wall motion and infarcted tissue were evaluated semi-quantitatively from SSFP cine sequences and contrast-enhanced-MR-images and were then related to myocardial strain. Comparison of peak circumferential strain assessed by SENC and MR-tagging was performed.
Ages Eligible for Study: | 30 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
Exclusion Criteria:
Germany | |
University Hospital Heidelberg | |
Heidelberg, Germany, 69120 |
Principal Investigator: | Mirja Neizel, MD | University Hospital Heidelberg |
Responsible Party: | Medical Clinic III, University Hospital Heidelberg ( Mirja Neizel, MD ) |
Study ID Numbers: | SENC in AMI |
Study First Received: | September 11, 2008 |
Last Updated: | September 15, 2008 |
ClinicalTrials.gov Identifier: | NCT00752713 History of Changes |
Health Authority: | Germany: Federal Institute for Drugs and Medical Devices |
AMI, Reperfusion successful reperfusion |
Necrosis Heart Diseases Myocardial Ischemia Vascular Diseases |
Ischemia Infarction Myocardial Infarction |
Necrosis Heart Diseases Pathologic Processes Myocardial Ischemia Vascular Diseases |
Cardiovascular Diseases Ischemia Infarction Myocardial Infarction |