Projects

CHARACTERIZATION AND ENHANCEMENT OF IMMUNE RESPONSES OF CALVES Appropriated (D)   Accession Number: 410387

RSV EFFECTS ON EPITHELIA DENDRITIC CELL CROSS TALK Reimbursable (R)   Accession Number: 410286

Publications

Laser Capture Microdissection Revisited as a Tool for Transcriptomic Analysis: Application of an Excel-Based qPCR Preparation Software (PREXCEL-Q) - (Peer Reviewed Journal) - (23-Mar-09)

Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus - (Peer Reviewed Journal) - (24-Jan-09)

The mononuclear phagocyte system and lymphocytes - (Book/Chapter) - (15-Aug-08)

Differences in immune response of pigs challenged with a high versus low dose inoculum of porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Lager, K.M., Sacco, R.E. 2008. Differences in immune response of pigs challenged with a high versus low dose inoculum of porcine reproductive and respiratory syndrome virus. Viral Immunology. 21(3):315-326.

Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica - (Proceedings/Symposium)

Brockmeier, S., Vincent, A.L., Loving, C.L., Nicholson, T.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica. In: Proceedings of the 20th International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. 1:10.

Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica - (Abstract)

Brockmeier, S., Loving, C.L., Nicholson, T.L., Vincent, A.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. American Society for Microbiology Meeting, June 2-4, 2008, Boston, Massachusetts. 2008 CDROM.

DNA vaccines against infectious agents: recent strategies for enhancing immune responses - (Review Article)

Sacco, R.E. 2008. DNA vaccines against infectious agents: Recent strategies for enhancing immune responses. Expert Opinion on Therapeutic Patents. 18(4):365-373.

Coinfection of Pigs with Swine Influenza Virus and Bordetella bronchiseptica - (Abstract)

Brockmeier, S., Vincent, A.L., Nicholson, T.L., Sacco, R.E., Palmer, M.V. 2007. Coinfection of Pigs with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. In: United States Japan Natural Resources Animal and Avian Health Panel, December 5, 2007, Tsukuba, Japan. p. 25.

Veterinary Applications for Monitoring Mononuclear Cell Proliferation Using Cell Tracking Dyes - (Peer Reviewed Journal)

Waters, W.R., Sacco, R.E. 2007. Veterinary Applications for Monitoring Mononuclear Cell Proliferation Using Cell Tracking Dyes. Immunological Investigations. 36(5-6):887-908.

Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene - (Peer Reviewed Journal)

Register, K.B., Sacco, R.E., Brockmeier, S. 2007. Immune response in mice and swine to DNA vaccines derived from the Pasteurella multocida toxin gene. Vaccine. 25(32):6118-28.

IL-4 induction in RSV-infected macrophages: examining the role of NFAT family members - (Abstract)

Levy, N.A., Fach, S.J., Sacco, R.E. 2007. IL-4 induction in RSV-infected macrophages: examining the role of NFAT family members [abstract]. American Association of Immunologists Proceedings. 178:B128.

Viruses as Predisposing Factors to Bacterial Pneumonia - (Abstract)

Lehmkuhl, H.D., Briggs, R.E., Sacco, R.E., Tatum, F.M. 2007. Viruses as Predisposing Factors to Bacterial Pneumonia [abstract]. Respiratory Disease in Mountain Sheep: Knowledge Gaps and Future Research. p. 154.

Immune Response in Mice and Swine to a DNA Vaccine Derived from the Pasteurella multocida toxin gene - (Abstract)

Register, K.B., Sacco, R.E., Brockmeier, S. 2007. Immune Response in Mice and Swine to a DNA Vaccine Derived from the Pasteurella multocida toxin gene[abstract]. American Society for Microbiology Meeting. May 21-25, 2007, Toronto, Canada. 2007 CD-ROM.

Coinfection with Swine Influenza Virus and Bordetella bronchiseptica in Pigs - (Abstract)

Brockmeier, S., Vincent, A.L., Sacco, R.E., Nicholson, T.L., Palmer, M.V. 2007. Coinfection with Swine Influenza Virus and Bordetella bronchiseptica in Pigs [abstract]. American Society for Microbiology Meeting, May 21-25,2007, Toronto, Canada. 2007 CD-ROM.

INNATE CYTOKINE RESPONSES IN PORCINE MACROPHAGE POPULATIONS: EVIDENCE FOR DIFFERENTIAL RECONGITION OF DSRNA - (Peer Reviewed Journal)

Loving, C.L., Brockmeier, S., Wenjun, M., Richt, J., Sacco, R.E. 2006. Innate Cytokine Responses in Porcine Macrophage Populations: Evidence for Differential Recongition of dsRNA. Journal of Immunology. 177:8432-8439.

NEONATAL OVINE PULMONARY DENDRITIC CELLS SUPPORT BRSV REPLICATION WITH ENHANCED IL-4 AND IL-10 GENE TRANSCRIPTS - (Peer Reviewed Journal)

Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2007. Neonatal Ovine Pulmonary Dendritic Cells Support BRSV Replication with Enhanced IL-4 and IL-10 Gene Transcripts. Viral Immunology. 20(1):119-130.

Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus - (Peer Reviewed Journal)

Loving, C.L., Brockmeier, S., Sacco, R.E. 2006. Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus. Immunology. 120:217-229.

Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus - (Abstract)

Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceedings of the 87th Conference of Research Workers in Animal Diseases, December 3-5, 2006. Chicago, Illinois. p.124.

Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus - (Abstract)

Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceeding of the International PRRS Symposium, December 1-2, 2006, Chicago, Illinois. p. 27.

IMMUNE RESPONSES OF ELK TO INITITAL AND BOOSTER VACCINATIONS WITH BRUCELLA ABORTUS STRAIN RB51 OR 19 - (Peer Reviewed Journal)

Olsen, S.C., Fach, S.J., Palmer, M.V., Sacco, R.E., Stoffregen, W.C., Waters, W.R. 2006. Immune Responses of Elk to Initital and Booster Vaccinations with Brucella abortus Strain RB51 or 19. Clinical and Vaccine Immunology. 13(10):1098-1103.

DIFFERENTIAL REGULATION OF TYPE I INTERFERON ACTIVATION IN MACROPHAGES - (Abstract)

Loving, C.L., Brockmeier, S., Sacco, R.E. 2006. Differential regulation of type I interferon activation in macrophages [abstract]. American Association of Immunologists Proceedings. 249:43-44.

PULMONARY DENDRITIC CELLS ISOLATED FROM NEONATAL AND ADULT OVINE LUNG TISSUE - (Peer Reviewed Journal)

Fach, S.J., Brockmeier, S., Hobbs, L.A., Lehmkuhl, H.D., Sacco, R.E. 2006. Pulmonary dendritic cells isolated from neonatal and adult ovine lung tissue. Veterinary Immunology and Immunopathology. 112(3-4):171-82.

COMPARATIVE NITRIC OXIDE PRODUCTION OF LPS-STIMULATED MONOCYTE-DERIVED MACROPHAGES FROM OVIS CANADENSIS AND OVIS ARIES - (Peer Reviewed Journal)

Sacco, R.E., Waters, W.R., Rudolph, K.M., Drew, M.L. 2006. Comparative nitric oxide production of LPS-stimulated monocyte-derived macrophages from Ovis canadensis and Ovis aries. Comparative Immunology Microbiology and Infectious Diseases. 29(1):1-11.

NEONATAL LAMB RESPIRATORY TRACT DENDRITIC CELLS AND THE EFFECTS OF RSV INFECTION - (Abstract)

Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2005. Neonatal lamb respiratory tract dendritic cells and the effects of RSV infection [abstract]. Federation of American Societies for Experimental Biology Conference. 19:A403.

PRRS VIRUS PRODUCTIVELY INFECTS MONOCYTE-DERIVED DENDRITIC CELLS AND INDUCES PRODUCTION OF INNATE ANTIVIRAL MEDIATORS - (Abstract)

Loving, C.L., Brockmeier, S., Sacco, R.E. 2005. Prrs virus productively infects monocyte-derived dendritic cells and induces production of innate antiviral mediators. Federation of American Societies for Experimental Biology Conference. 19:A404.

EFFECT OF BRSV INFECTION IN NEONATAL LAMBS ON RESPIRATORY TRACT DENDRITIC CELLS - (Abstract)

Fach, S.J., Meyerholz, D.K., Gallup, J.M., Ackermann, M.R., Lehmkuhl, H.D., Sacco, R.E. 2004. Effect of BRSV infection in neonatal lambs on respiratory tract dendritic cells [abstract]. Autumn Immunology Conference. p. 52.

INNATE IMMUNITY OF RESPIRATORY EPITHELIA: EFFECTS OF PRETERM BIRTH AND RESPIRATORY SYNCYTIAL VIRUS INFECTION - (Abstract)

Ackermann, M.R., Meyerholz, D.K., Grubor, B., Lehmkuhl, H.D., Sacco, R.E., Gallup, J.M., Derscheid, R., Lazic, T., Fach, S., Kawashima, K. 2004. Innate immunity of respiratory epithelia: effects of preterm birth and respiratory syncytial virus infection [abstract]. Conference of Research Workers in Animal Diseases. p. 136.

INCREASED SEVERITY OF BOVINE RESPIRATORY SYNCYTIAL VIRUS INFECTION IN PRETERM LAMBS - (Abstract)

Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. 2004. Increased severity of bovine respiratory syncytial virus infection in preterm lambs [abstract]. Bi-Annual All-Iowa Virology Symposium. Paper No. 12.

COMPARISON OF THE EXPRESSED PORCINE VBETA AND JBETA REPERTOIRE OF THYMOCYTES AND PERIPHERAL T-CELLS - (Peer Reviewed Journal)

Butler, J.E., Wertz, N., Sun, J., Sacco, R.E. 2005. Comparison of the expressed porcine vbeta and jbeta repertoire of thymocytes and peripheral t-cells. Immunology. 114:184-193.

REDUCED CLEARANCE OF RESPIRATORY SYNCYTIAL VIRUS IN A PRETERM LAMB MODEL - (Peer Reviewed Journal)

Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. 2004. Reduced clearance of respiratory syncytial virus in a preterm lamb model. Microbes and Infection. 6(14):1312-1319.

IMMUNE RESPONSE TO A DNA VACCINE DERIVED FROM THE PASTEURELLA MULTOCIDA TOXIN GENE - (Proceedings/Symposium)

Register, K.B., Sacco, R.E., Brockmeier, S. 2004. Immune response to a dna vaccine derived from the pasteurella multocida toxin gene. Pig Veterinary Society International Congress Proceedings. p. 200.

RESPIRATORY SYNCYTIAL VIRUS INFECTION IN PRETERM LAMBS - (Abstract)

Meyerholz, D.K., Grubor, B., Fach, S.J., Sacco, R.E., Ensley, D., Lehmkuhl, H.D., Gallup, J.M., Ackermann, M.R. Respiratory syncytial virus infection in preterm lambs. 2004. Presented at FASEB Meeting. Abstract No. 1074.

THE EFFECTS OF PASTEURELLA MULTOCIDA TOXIN (PMT) ON EARLY MURINE B-LINEAGE CELLS - (Abstract)

Loving, C.L., Sacco, R.E. 2003. The effects of pasteurella multocida toxin (pmt) on early murine b-lineage cells. Autumn Immunology Conference Proceedings. Abstract No. 140, p. 54.

THE EFFECTS OF PASTEURELLA MULTOCIDA TOXIN (PMT) ON EARLY MURINE B-LINEAGE CELLS - (Abstract)

Loving, C.L., Sacco, R.E. 2003. The effects of Pasteurella multocida toxin (pmt) on early murine b-lineage cells. Immunology Research Workshop. December 2, 2003.

ANALYSIS OF LYMPHOCYTES ISOLATED FROM WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FAWNS - (Abstract)

Fach, S.J., Waters, W.R., Palmer, M.V., Davis, W.C., Sacco, R.E. 2003. Analysis of lymphocytes isolated from white-tailed deer (odocoileus virginianus) fawns. Immunology Research Workshop. December 2, 2003.

RE-EMERGENCE OF BORDETELLA BRONCHISPETICA DURING THE RECENT SEAL MORBILLIVIRUS OUTBREAK - (Proceedings/Symposium)

FOSTER, G., REGISTER, K.B., SACCO, R.E., PATTERSON, I.P. RE-EMERGENCE OF BORDETELLA BRONCHISPETICA DURING THE RECENT SEAL MORBILLIVIRUS OUTBREAK. PROCEEDINGS OF THE SCOTTISH AGRICULTURAL COLLEGE OF VETERINARY SCIENCES CONFERENCE. SEPTEMBER 10-11, 2003. p. 21.

DEFENSIN-INDUCED ADAPTIVE IMMUNITY IN MICE AND ITS POTENTIAL IN PREVENTING PERIODONTAL DISEASE - (Peer Reviewed Journal)

Brogden, K.A., Heidari, M., Sacco, R.E., Palmquist, D.E., Guthmiller, J.M., Johnson, G.K., Jia, H.P., Tack, B.F., Mccray, P.B. 2003. Defensin-induced adaptive immunity in mice and its potential in preventing periodontal disease. Oral Microbiology and Immunology. Vol. 18:95-99.

COMPARISON BETWEEN RIBOTYPING AND RESTRICTION ENZYME ANALYSIS FOR INTER- AND INTRASPECIES DISCRIMINATION OF BORDETELLA AVIUM AND BORDETELLA HINZII - (Peer Reviewed Journal)

REGISTER, K.B., SACCO, R.E., NORDHOLM, G.E. COMPARISON OF RIBOTYPING AND RESTRICTION ENZYME ANALYSIS FOR INTER- AND INTRASPECIES DISCRIMINATION OF BORDETELLA AVIUM AND BORDETELLA HINZII. JOURNAL OF CLINICAL MICROBIOLOGY. 2003. v. 41(4). p. 1512-1519.

IMMUNE RESPONSES OF ELK TO MYCOBACTERIUM BOVIS BACILLUS CALMETTE GUERIN VACCINATION - (Peer Reviewed Journal)

Waters, W.R., Palmer, M.V., Olsen, S.C., Sacco, R.E., Whipple, D.L. 2003. Immune responses of elk to mycobacterium bovis bacillus calmette guerin vaccination. Vaccine. Vol. 21(13-14), p. 1518-1526.

ANALYSIS OF LYMPHOCYTES ISOLATED FROM WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FAWNS - (Abstract) - (02-Aug-02)

BHUR, A VIRULENCE-ASSOCIATED OUTER MEMBRANE PROTEIN OF BORDETELLA AVIUM, IS REQUIRED FOR THE ACQUISITION OF IRON FROM HEME AND HEMOPROTEINS - (Peer Reviewed Journal)

MURPHY, E.R., SACCO, R.E., DICKENSON, A., METZGER, D.J., HU, Y., ORNDORFF, P.E., CONNELL, T.D. BHUR, A VIRULENCE-ASSOCIATED OUTER MEMBRANE PROTEIN OF BORDETELLA AVIUM, IS REQUIRED FOR THE ACQUISITION OF IRON FROM HEME AND HEMOPROTEINS. INFECTION AND IMMUNITY. 2002. v. 70(10). p. 5390-5403.

INDUCTION OF TH2-LIKE IMMUNE RESPONSES BY C3H MICE BEARING A DEFINED FLORA FOLLOWING ONSET OF COLITIS - (Abstract) - (03-Jul-02)