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Sponsored by: |
Imperial College London |
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Information provided by: | Imperial College London |
ClinicalTrials.gov Identifier: | NCT00230672 |
Hereditary Haemorrhagic Telangiectasia (HHT, also known as Osler-Weber-Rendu Syndrome) is an disease that leads to the development of dilated and fragile blood vessels, including arteriovenous malformations in the lungs (PAVMs). We hypothesize that the genetically-determined abnormality in the blood vessels of HHT patients leads to alteration in the concentrations or activity of several proteins in the blood stream. We propose to take blood samples from patients at defined times in order to study changes in blood protein levels and activity
Condition |
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Telangiectasia, Hereditary Hemorrhagic |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Studies of Plasma Proteins Derived From Pulmonary Arteriovenous Malformation Patients |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:Patients with hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations -
Exclusion Criteria:Unable to provide informed consent
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Contact: Claire Shovlin | 0208 383 1000 | c.shovlin@imperial.ac.uk |
United Kingdom | |
Imperial College Hammersmith Campus | Recruiting |
London, United Kingdom, W12 0NN | |
Contact: Claire Shovlin 0208 383 1000 c.shovlin@imperial.ac.uk |
Principal Investigator: | Claire Shovlin | Imperial College London |
Study ID Numbers: | IC/CLS7 |
Study First Received: | September 29, 2005 |
Last Updated: | August 12, 2008 |
ClinicalTrials.gov Identifier: | NCT00230672 History of Changes |
Health Authority: | United Kingdom: Research Ethics Committee |
Pulmonary Arteriovenous Malformation Cardiovascular Abnormalities Telangiectasia, Hereditary Hemorrhagic Hematologic Diseases Blood Coagulation Disorders Vascular Diseases Hemostatic Disorders |
Hemorrhagic Disorders Telangiectasis Vascular Malformations Arteriovenous Malformations Hereditary Hemorrhagic Telangiectasia Congenital Abnormalities |
Hemorrhagic Disorders Cardiovascular Abnormalities Hematologic Diseases Telangiectasia, Hereditary Hemorrhagic Vascular Malformations Telangiectasis |
Vascular Diseases Cardiovascular Diseases Arteriovenous Malformations Hemostatic Disorders Congenital Abnormalities |