Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsors and Collaborators: |
University of Munich Children's Clinic Ludwig-Maximilians - University of Munich |
---|---|
Information provided by: | University of Munich Children's Clinic |
ClinicalTrials.gov Identifier: | NCT00230412 |
The purpose of our study is to determine whether the production of heat shock proteins has an effect on the development and the outcome of acute renal failure in children.
Condition |
---|
Kidney Failure, Acute |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Study of Heat Shock Proteins as Prognostic Factor of Acute Renal Failure in Children (HSP-Study) |
Whole blood, serum and urine.
Estimated Enrollment: | 120 |
Study Start Date: | October 2005 |
Estimated Study Completion Date: | September 2008 |
A prognostic factor for the development of acute renal failure (ANR) in children would be very valuable for therapy regulation. So-called chaperones out of the family of heat shock proteins (HSP) are promising candidates which are involved in the development of ANR as well. This could be a starting point for the development of new therapeutic approaches.
ANR occurs in up to 50 percent of all critical ill patients and has a high rate of morbidity and mortality despite advances in symptomatic therapy.
Following severe sepsis, septic shock or other shocks, combined with multiple organ failure, the ANR is an autonomous prognosis worsening factor.
Should the results of our study show a correlation between the production of HSP and the outcome of children with ANR, further studies would be required, to examine the pathophysiological relevance of HSP in ANR. We would then be able to determine a high risk population for ANR. A modulation of ANR therapy might be a result of further studies.
Ages Eligible for Study: | up to 18 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Patients on paediatric intensive care units.
Inclusion Criteria:
Exclusion Criteria:
Contact: Dennis A. Ballwieser, cand. med. | +49-89-5160-7813 | dennis.ballwieser@med.uni-muenchen.de |
Contact: Judith Glöckner-Pagel, Dr. med. | +49-89-5160-7895 | judith.gloeckner@med.uni-muenchen.de |
Germany, Bavaria | |
Klinikum der Universität München, Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital | Recruiting |
Munich, Bavaria, Germany, 80337 | |
Contact: Dennis A. Ballwieser, cand. med. +49-89-5160-7813 dennis.ballwieser@med.uni-muenchen.de | |
Contact: Judith Glöckner-Pagel, Dr. med. +49-89-5160-7895 judith.gloeckner@med.uni-muenchen.de | |
Principal Investigator: Dennis A. Ballwieser, cand. med. | |
Principal Investigator: Judith Glöckner, Dr. med. | |
Principal Investigator: Karl Reiter, Dr. med. | |
Kinderklinik Memmingen | Recruiting |
Memmingen, Bavaria, Germany, 87700 | |
Contact: Martin Ries, Prof. Dr. +49-8331-70-2300 info@kinderklinik-memmingen.de | |
Principal Investigator: Dennis A Ballwieser, cand. med. | |
Sub-Investigator: Benjamin Ackermann, cand. med. | |
Klinikum Augsburg, II. Klinik für Kinder und Jugendliche | Recruiting |
Augsburg, Bavaria, Germany, 86156 | |
Contact: Gernot Buheitel, Prof. Dr. +49-821-400-3431 sekretariat@2.kk.augsburg-med.de | |
Contact: Wilfried Schenk, Dr. med. +49-821-400-3431 sekretariat@2.kk.augsburg-med.de | |
Principal Investigator: Dennis A Ballwieser, cand. med. | |
Kinderklinik Rosenheim | Recruiting |
Rosenheim, Bavaria, Germany, 83022 | |
Contact: Torsten Uhlig, Dr. med. +49-8031-3634-51 kinderklinik@kliro.de | |
Contact: Wolfgang John, Dr. med. +49-8031-3634-51 kinderklinik@kliro.de | |
Principal Investigator: Dennis A Ballwieser, cand. med. | |
Klinkum der Barmherzigen Brüder St. Hedwig | Recruiting |
Regensburg, Bavaria, Germany, 93049 | |
Contact: Hugo Segerer, Prof. Dr. +49-941-369-5401 kinderundjugendmedizin@barmherzige-regensburg.de | |
Contact: Peter Schindler, Physician +49-941-369-5401 kinderundjugendmedizin@barmherzige-regensburg.de | |
Principal Investigator: Dennis A Ballwieser, cand. med. |
Study Chair: | Karl Reiter, Dr. med. | Klinikum der Universität München, Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital |
Study Director: | Judith Glöckner-Pagel, Dr. med. | Klinikum der Universität München, Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital |
Principal Investigator: | Dennis A. Ballwieser, cand. med. | Klinikum der Universität München, Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital |
Responsible Party: | LMU Munich ( Dennis Ballwieser ) |
Study ID Numbers: | HSP-233-05, Projektnummer 233-05 |
Study First Received: | September 28, 2005 |
Last Updated: | December 6, 2007 |
ClinicalTrials.gov Identifier: | NCT00230412 History of Changes |
Health Authority: | Germany: Federal Institute for Drugs and Medical Devices |
Kidney Failure, Acute Acute Renal Failure Kidney Failure Heat-Shock Proteins Children |
Renal Insufficiency Urologic Diseases Shock Renal Insufficiency, Acute |
Kidney Diseases Kidney Failure, Acute Kidney Failure |
Renal Insufficiency Urologic Diseases Renal Insufficiency, Acute |
Kidney Diseases Kidney Failure, Acute Kidney Failure |