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stavudine
A synthetic nucleoside, analog of didehydro-3-deoxythymidine with potent antiretroviral activity. In vivo, stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate; this metabolite inhibits the activity of HIV reverse transcriptase both by competing with the natural substrate deoxythymidine triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack the essential 3'-OH group). Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | didehydrodeoxythymidine
dideoxydidehydrothymidine | | | | US brand name: | | Zerit | | | | Abbreviation: | | d4T | | | | Code name: | | BMY-27857 | | | | Chemical structure names: | | - 1-(2,3-dideoxy-beta-glycero-pent-2-enofuranosyl)thymine
- 2',3'-didehydro-3'-deoxythymidine
- 3'-deoxy-2'-thymidinene
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