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plicamycin An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090509160055im_/http://www.cancer.gov/images/spacer.gif) | aureolic acid mithramycin | | ![](https://webarchive.library.unt.edu/eot2008/20090509160055im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509160055im_/http://www.cancer.gov/images/spacer.gif) | Mithracin | | ![](https://webarchive.library.unt.edu/eot2008/20090509160055im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509160055im_/http://www.cancer.gov/images/spacer.gif) | Mithracine | | ![](https://webarchive.library.unt.edu/eot2008/20090509160055im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090509160055im_/http://www.cancer.gov/images/spacer.gif) | MTH | | ![](https://webarchive.library.unt.edu/eot2008/20090509160055im_/http://www.cancer.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20090509160055im_/http://www.cancer.gov/images/spacer.gif) | A-2371 PA-144 | | ![](https://webarchive.library.unt.edu/eot2008/20090509160055im_/http://www.cancer.gov/images/spacer.gif) |
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