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anthracycline analogue GPX-150 A synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509154401im_/http://www.cancer.gov/images/spacer.gif) | GPX-150 | | ![](https://webarchive.library.unt.edu/eot2008/20090509154401im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20090509154401im_/http://www.cancer.gov/images/spacer.gif) | 5-imino-13-deoxydoxoubicin | | ![](https://webarchive.library.unt.edu/eot2008/20090509154401im_/http://www.cancer.gov/images/spacer.gif) |
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