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anti-DR5 agonist monoclonal antibody TRA-8 An agonist mouse monoclonal antibody directed against TRAIL death receptor type 5 (DR5) with potential antineoplastic activity. Anti-DR5 agonist monoclonal antibody TRA-8 binds DR5, which may induce apoptosis in DR5-expressing tumor cells. DR5 is a tumor cell surface ligand that crosslinks with death receptor type 4 (DR4) when bound by TRAIL [Tumor necrosis (TNF)-related apoptosis-inducing ligand], triggering apoptosis via a death receptor signaling pathway. The apoptotic activity of this antibody may not require DR4/DR5 crosslinking. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090511132218im_/http://www.cancer.gov/images/spacer.gif) | anti-death receptor 5 agonist monoclonal antibody TRA-8 | | ![](https://webarchive.library.unt.edu/eot2008/20090511132218im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090511132218im_/http://www.cancer.gov/images/spacer.gif) | TRA-8 | | ![](https://webarchive.library.unt.edu/eot2008/20090511132218im_/http://www.cancer.gov/images/spacer.gif) |
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