![](https://webarchive.library.unt.edu/eot2008/20090511132119im_/http://www.cancer.gov/images/spacer.gif) |
|
![](https://webarchive.library.unt.edu/eot2008/20090511132119im_/http://www.cancer.gov/images/spacer.gif)
anti-EpCAM antibody fragment -Pseudomonas exotoxin fusion protein A fusion protein immunotoxin consisting of a humanized, single-chain monoclonal antibody fragment specific for the epithelial cell adhesion molecule (EpCAM) conjugated with a truncated form of Pseudomonas exotoxin A with potential antineoplastic activity. Anti-EpCAM-Pseudomonas-exotoxin fusion protein binds to Ep-CAM-positive tumor cells, thereby delivering the Pseudomonas exotoxin A moiety specifically; the Pseudomonas exotoxin A moiety then inactivates elongation factor 2 (EF-2) through ADP ribosylation, resulting in inhibition of protein synthesis in target cells. EpCAM, a cell surface protein, is expressed by a variety of tumor cells and is frequently found in head and neck cancers. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/eot2008/20090511132119im_/http://www.cancer.gov/images/spacer.gif)
Foreign brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090511132119im_/http://www.cancer.gov/images/spacer.gif) | Proxinium Vicinium | | ![](https://webarchive.library.unt.edu/eot2008/20090511132119im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090511132119im_/http://www.cancer.gov/images/spacer.gif) | VB4-845 | | ![](https://webarchive.library.unt.edu/eot2008/20090511132119im_/http://www.cancer.gov/images/spacer.gif) |
![](https://webarchive.library.unt.edu/eot2008/20090511132119im_/http://www.cancer.gov/images/spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20090511132119im_/http://www.cancer.gov/images/gray_spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20090511132119im_/http://www.cancer.gov/images/spacer.gif)
|
![](https://webarchive.library.unt.edu/eot2008/20090511132119im_/http://www.cancer.gov/images/spacer.gif) |