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stavudine A synthetic nucleoside, analog of didehydro-3-deoxythymidine with potent antiretroviral activity. In vivo, stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate; this metabolite inhibits the activity of HIV reverse transcriptase both by competing with the natural substrate deoxythymidine triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack the essential 3'-OH group). Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090509174949im_/http://www.cancer.gov/images/spacer.gif) | didehydrodeoxythymidine dideoxydidehydrothymidine | | ![](https://webarchive.library.unt.edu/eot2008/20090509174949im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509174949im_/http://www.cancer.gov/images/spacer.gif) | Zerit | | ![](https://webarchive.library.unt.edu/eot2008/20090509174949im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090509174949im_/http://www.cancer.gov/images/spacer.gif) | d4T | | ![](https://webarchive.library.unt.edu/eot2008/20090509174949im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509174949im_/http://www.cancer.gov/images/spacer.gif) | BMY-27857 | | ![](https://webarchive.library.unt.edu/eot2008/20090509174949im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20090509174949im_/http://www.cancer.gov/images/spacer.gif) | - 1-(2,3-dideoxy-beta-glycero-pent-2-enofuranosyl)thymine
- 2',3'-didehydro-3'-deoxythymidine
- 3'-deoxy-2'-thymidinene
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