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Sponsored by: |
National Taiwan University Hospital |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00243958 |
Hearing impairment either clinical or subclinical is a characteristic of some renal disease patients. The hearing impairment could be result from specific etiologies or chronic renal failure itself. The causes of hearing impairment in renal disease patients ranged from drugs intoxication in both auditory and renal function, like gentamycin or isoniazid, congenital disease like Alport syndrome or other collagen-defective renal disease, or just aging related. End-stage renal disease (ESRD) patients are special in many parts to general population who have hearing impairment. First, inflammation in ESRD patients is well-documented, second, they suffered from various underlying diseases which auditory function was potentially impaired, third, they need to undergo renal replacement therapy either hemodialysis (HD) or peritoneal dialysis (PD) to maintain their life. Dialysis itself was found to be a cause of hearing impairment, too. The biochemical change and constitutive inflammation status are thought to be implicated in the pathogenesis of hearing impairment in ESRD patients. Aluminum (Al) is a well-documented heavy metal, which predisposes to Alzheimer’s disease, dementia or some neurologic diseases. Al intoxication is very rare in general health population but elevated serum Al level is easily found in ESRD patients since they can not excrete Al by damaged kidneys and dialyzers. Inner ear per se is a neurologic tissue, so if serum Al level in ESRD patients has any association in their haring function needs to be studied.
Condition |
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End-Stage Renal Disease (ESRD) |
Study Type: | Observational |
Study Design: | Screening, Cross-Sectional, Case Control, Retrospective/Prospective Study |
Ages Eligible for Study: | 20 Years to 75 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
ESRD patients and healthy volunteers, without history of occupational noise exposure, ear infection, ear surgery, active systemic infection, previous ototoxic drugs exposure or congenital hearing defect
Exclusion Criteria:
Unsuitable to undergo hearing test, with history of occupational noise exposure, ear infection, ear surgery, active systemic infection, previous ototoxic drugs exposure or congenital hearing defect
Contact: Pei-Lun Chu, MD,MMS | 886-5-5320409 ext 5755 | plchu@ha.mc.ntu.edu.tw |
Taiwan, Yun-Lin | |
National Taiwan University Hospital, Yun-Lin Branch | Recruiting |
Dou-Liu, Yun-Lin, Taiwan | |
Contact: Pei-Lun Chu, MD, MMS 886-5-5320409 ext 5775 plchu@ha.mc.ntu.edu.tw | |
Principal Investigator: Pei-Lun Chu, MD, MMS | |
National Taiwan University Hospital, Yun-Lin Branch | Recruiting |
Dou-Liu, Yun-Lin, Taiwan | |
Contact: Pei-Lun Chu, MD, MMS 886-5-5320409 ext 5755 plchu@ha.mc.ntu.edu.tw |
Study Chair: | Kwan-Dun Wu, MD. PhD | National Taiwan University Hospital |
Study ID Numbers: | 9461701003 |
Study First Received: | October 23, 2005 |
Last Updated: | October 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00243958 History of Changes |
Health Authority: | Taiwan: Department of Health |
Renal Insufficiency Urologic Diseases Renal Insufficiency, Chronic |
Kidney Failure, Chronic Kidney Diseases Kidney Failure |
Renal Insufficiency Urologic Diseases Renal Insufficiency, Chronic |
Kidney Failure, Chronic Kidney Diseases Kidney Failure |