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Office of Population Genomics
Recent Publications
- Collaborative genome-wide association studies of diverse diseases: Programs of the NHGRI's Office of Population Genomics [ncbi.nlm.nih.gov]
Manolio TA. Pharmacogenomics, 10:235-241. 2009.
- Size matters: realistic power calculations for genetic association studies in the genomics age [ncbi.nlm.nih.gov]
Burton PR, Hansell AL, Fortier I, Manolio TA, Khoury MJ, Little J, Elliott P. International Journal of Epidemiology, 38:263-73. 2009.
- Cohort studies and the genetics of complex disease [ncbi.nlm.nih.gov]
Manolio TA. Nature Genetics, 41:5-6. 2009.
- A HapMap harvest of insights into the genetics of common disease [ncbi.nlm.nih.gov]
Manolio TA, Brooks LD, Collins FS. Journal of Clinical Investigation, 118:1590-1625. 2008.
- How to Interpret a Genome-wide Association Study [jama.ama-assn.org]
This article describes the design, interpretation, application, and limitations of GWA studies for clinicians and scientists for whom this evolving science may have great relevance.
- HapMap harvest of insights into the genetics of common disease [ncbi.nlm.nih.gov]
This article discusses the benefits and successes of the International HapMap Project.
- Biorepositories at the bleeding edge [ncbi.nlm.nih.gov]
An article on biorepositories, or "biobanks," discussing their benefits and limitations.
- New models of collaboration in genome-wide association studies: the Genetic Association Information Network
A description of the Genetic Association Information Network (GAIN) and its contribution as a new method of research aiming towards rapid advances in the understanding of the genetics of complex diseases.
- Replicating genotype-phenotype associations
![PDF file](https://webarchive.library.unt.edu/eot2008/20090508173948im_/http://genome.gov/Images/icons/pdf_icon.gif)
The importance of replication, and how to define it.
- Genes, environment, health, and disease: facing up to complexity [ncbi.nlm.nih.gov]
Understanding the complexity of human disease, and how to identify and interpret gene x gene and gene x environment interactions.
- Merging and emerging cohorts: necessary but not sufficient
![PDF file](https://webarchive.library.unt.edu/eot2008/20090508173948im_/http://genome.gov/Images/icons/pdf_icon.gif)
A commentary on the benefits and pitfalls of extending existing cohorts versus starting new cohorts.
- Taking our obligations to research participants seriously: disclosing individual results of genetic research [ncbi.nlm.nih.gov]
A commentary on disclosure of results to research participants.
- Genes, environment and the value of prospective cohort studies
![PDF file](https://webarchive.library.unt.edu/eot2008/20090508173948im_/http://genome.gov/Images/icons/pdf_icon.gif)
This article discusses the importance of prospective cohort studies.
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Last Updated: March 30, 2009
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