Office of Population Genomics

Overview A Catalog of Genome-Wide Association Studies Research Programs Recent Publications Meetings & Workshops Notices & Funding Opportunities Contact

Recent Publications

• Collaborative genome-wide association studies of diverse diseases: Programs of the NHGRI's Office of Population Genomics [ncbi.nlm.nih.gov]
  Manolio TA. Pharmacogenomics, 10:235-241. 2009.
  
  
• Size matters: realistic power calculations for genetic association studies in the genomics age [ncbi.nlm.nih.gov]
  Burton PR, Hansell AL, Fortier I, Manolio TA, Khoury MJ, Little J, Elliott P. International Journal of Epidemiology, 38:263-73. 2009.
  
  
• Cohort studies and the genetics of complex disease [ncbi.nlm.nih.gov]
  Manolio TA. Nature Genetics, 41:5-6. 2009.
  
  
• A HapMap harvest of insights into the genetics of common disease [ncbi.nlm.nih.gov]
  Manolio TA, Brooks LD, Collins FS. Journal of Clinical Investigation, 118:1590-1625. 2008.
  
  
• How to Interpret a Genome-wide Association Study [jama.ama-assn.org]
  This article describes the design, interpretation, application, and limitations of GWA studies for clinicians and scientists for whom this evolving science may have great relevance.
  
  
• HapMap harvest of insights into the genetics of common disease [ncbi.nlm.nih.gov]
  This article discusses the benefits and successes of the International HapMap Project.
  
  
• Biorepositories at the bleeding edge [ncbi.nlm.nih.gov]
  An article on biorepositories, or "biobanks," discussing their benefits and limitations.
  
  
• New models of collaboration in genome-wide association studies: the Genetic Association Information Network
  A description of the Genetic Association Information Network (GAIN) and its contribution as a new method of research aiming towards rapid advances in the understanding of the genetics of complex diseases.
  
  
• Replicating genotype-phenotype associations
  The importance of replication, and how to define it.
  
  
• Genes, environment, health, and disease: facing up to complexity [ncbi.nlm.nih.gov]
  Understanding the complexity of human disease, and how to identify and interpret gene x gene and gene x environment interactions.
  
  
• Merging and emerging cohorts: necessary but not sufficient
  A commentary on the benefits and pitfalls of extending existing cohorts versus starting new cohorts.
  
  
• Taking our obligations to research participants seriously: disclosing individual results of genetic research [ncbi.nlm.nih.gov]
  A commentary on disclosure of results to research participants.
  
  
• Genes, environment and the value of prospective cohort studies
  This article discusses the importance of prospective cohort studies.

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Last Updated: March 30, 2009