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Sponsored by: |
Göteborg University |
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Information provided by: | Göteborg University |
ClinicalTrials.gov Identifier: | NCT00473980 |
The study is designed to evaluate effects of NSAIDs on immune activity inside and close to tumor tissue in patients with colorectal cancer.
Condition | Intervention | Phase |
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Colorectal Cancer |
Drug: Indomethacin, celecoxib, esomeprazole |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | Preoperative Treatment With NSAID in Colorectal Cancer Patients in Relationship to Tumor Host Reactions |
Enrollment: | 28 |
Study Start Date: | December 1998 |
Study Completion Date: | May 2007 |
Study and control patients are randomized to receive preoperative treatment with indomethacin or celecoxib compared to sham treatment.Tumor biopsies are taken at operation and used for analyses of tumor immunity and gene expression.
Ages Eligible for Study: | 40 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | kl4501122 |
Study First Received: | May 15, 2007 |
Last Updated: | May 15, 2007 |
ClinicalTrials.gov Identifier: | NCT00473980 History of Changes |
Health Authority: | Sweden: The National Board of Health and Welfare |
MHC CTLs Colon carcinoma NSAID Survival |
Anti-Inflammatory Agents Digestive System Neoplasms Celecoxib Gastrointestinal Diseases Cyclooxygenase Inhibitors Colonic Diseases Omeprazole Cardiovascular Agents Intestinal Diseases Rectal Diseases Intestinal Neoplasms |
Carcinoma Digestive System Diseases Analgesics, Non-Narcotic Indomethacin Gastrointestinal Neoplasms Anti-Inflammatory Agents, Non-Steroidal Peripheral Nervous System Agents Analgesics Antirheumatic Agents Colorectal Neoplasms |
Anti-Inflammatory Agents Molecular Mechanisms of Pharmacological Action Gastrointestinal Diseases Colonic Diseases Physiological Effects of Drugs Omeprazole Reproductive Control Agents Rectal Diseases Gout Suppressants Neoplasms by Site Tocolytic Agents Sensory System Agents Therapeutic Uses Anti-Ulcer Agents Indomethacin |
Anti-Inflammatory Agents, Non-Steroidal Analgesics Digestive System Neoplasms Cyclooxygenase Inhibitors Gastrointestinal Agents Enzyme Inhibitors Cardiovascular Agents Intestinal Diseases Intestinal Neoplasms Pharmacologic Actions Neoplasms Digestive System Diseases Analgesics, Non-Narcotic Gastrointestinal Neoplasms Peripheral Nervous System Agents |