| | This journal provides immediate access to some articles. Opinion Infectious Diseases of the Nervous System and Their Impact in Developing Countries Roberto Bruzzone, Monique Dubois-Dalcq, Georges E. Grau, Diane E. Griffin, and Krister Kristensson PLoS Pathog. 2009 February; 5(2): e1000199. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000199.PMCID: PMC2642628 Research Articles An RIG-I-Like RNA Helicase Mediates Antiviral RNAi Downstream of Viral siRNA Biogenesis in Caenorhabditis elegans Rui Lu, Erbay Yigit, Wan-Xiang Li, and Shou-Wei Ding PLoS Pathog. 2009 February; 5(2): e1000286. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000286.PMCID: PMC2629121 Rift Valley Fever Virus NSs Protein Promotes Post-Transcriptional Downregulation of Protein Kinase PKR and Inhibits eIF2α Phosphorylation Tetsuro Ikegami, Krishna Narayanan, Sungyong Won, Wataru Kamitani, C. J. Peters, and Shinji Makino PLoS Pathog. 2009 February; 5(2): e1000287. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000287.PMCID: PMC2629125 Disruption of the Toxoplasma gondii Parasitophorous Vacuole by IFNγ-Inducible Immunity-Related GTPases (IRG Proteins) Triggers Necrotic Cell Death Yang O. Zhao, Aliaksandr Khaminets, Julia P. Hunn, and Jonathan C. Howard PLoS Pathog. 2009 February; 5(2): e1000288. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000288.PMCID: PMC2629126 Phthiocerol Dimycocerosates of M. tuberculosis Participate in Macrophage Invasion by Inducing Changes in the Organization of Plasma Membrane Lipids Catherine Astarie-Dequeker, Laurent Le Guyader, Wladimir Malaga, Fam-Ky Seaphanh, Christian Chalut, André Lopez, and Christophe Guilhot PLoS Pathog. 2009 February; 5(2): e1000289. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000289.PMCID: PMC2632888 Pep1, a Secreted Effector Protein of Ustilago maydis, Is Required for Successful Invasion of Plant Cells Gunther Doehlemann, Karina van der Linde, Daniela Aßmann, Daniela Schwammbach, Alexander Hof, Amitabh Mohanty, David Jackson, and Regine Kahmann PLoS Pathog. 2009 February; 5(2): e1000290. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000290.PMCID: PMC2631132 HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice Michael A. Joyce, Kathie-Anne Walters, Sue-Ellen Lamb, Mathew M. Yeh, Lin-Fu Zhu, Norman Kneteman, Jason S. Doyle, Michael G. Katze, and D. Lorne Tyrrell PLoS Pathog. 2009 February; 5(2): e1000291. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000291.PMCID: PMC2647842 Differences in APOBEC3G Expression in CD4+ T Helper Lymphocyte Subtypes Modulate HIV-1 Infectivity Michael L. Vetter, Megan E. Johnson, Amanda K. Antons, Derya Unutmaz, and Richard T. D'Aquila PLoS Pathog. 2009 February; 5(2): e1000292. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000292.PMCID: PMC2631133 Detailed Analysis of Sequence Changes Occurring during vlsE Antigenic Variation in the Mouse Model of Borrelia burgdorferi Infection Loïc Coutte, Douglas J. Botkin, Lihui Gao, and Steven J. Norris PLoS Pathog. 2009 February; 5(2): e1000293. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000293.PMCID: PMC2632889 The Protein Kinase Tor1 Regulates Adhesin Gene Expression in Candida albicans Robert J. Bastidas, Joseph Heitman, and Maria E. Cardenas PLoS Pathog. 2009 February; 5(2): e1000294. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000294.PMCID: PMC2631134 Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection David Favre, Sharon Lederer, Bittoo Kanwar, Zhong-Min Ma, Sean Proll, Zeljka Kasakow, Jeff Mold, Louise Swainson, Jason D. Barbour, Carole R. Baskin, Robert Palermo, Ivona Pandrea, Christopher J. Miller, Michael G. Katze, and Joseph M. McCune PLoS Pathog. 2009 February; 5(2): e1000295. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000295.PMCID: PMC2635016 Transcriptional Profiling in Pathogenic and Non-Pathogenic SIV Infections Reveals Significant Distinctions in Kinetics and Tissue Compartmentalization Sharon Lederer, David Favre, Kathie-Anne Walters, Sean Proll, Bittoo Kanwar, Zeljka Kasakow, Carole R. Baskin, Robert Palermo, Joseph M. McCune, and Michael G. Katze PLoS Pathog. 2009 February; 5(2): e1000296. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000296.PMCID: PMC2633618 The Macrophage Scavenger Receptor A Is Host-Protective in Experimental Meningococcal Septicaemia Annette Plüddemann, J. Claire Hoe, Katherine Makepeace, E. Richard Moxon, and Siamon Gordon PLoS Pathog. 2009 February; 5(2): e1000297. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000297.PMCID: PMC2633608 Myd88 Is Required for an Antibody Response to Retroviral Infection Edward P. Browne and Dan R. Littman PLoS Pathog. 2009 February; 5(2): e1000298. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000298.PMCID: PMC2633609 Dengue Virus Type 2 Infections of Aedes aegypti Are Modulated by the Mosquito's RNA Interference Pathway Irma Sánchez-Vargas, Jaclyn C. Scott, B. Katherine Poole-Smith, Alexander W. E. Franz, Valérie Barbosa-Solomieu, Jeffrey Wilusz, Ken E. Olson, and Carol D. Blair PLoS Pathog. 2009 February; 5(2): e1000299. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000299.PMCID: PMC2633610 Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain Variants Matthew W. McNatt, Trinity Zang, Theodora Hatziioannou, Mackenzie Bartlett, Ismael Ben Fofana, Welkin E. Johnson, Stuart J. D. Neil, and Paul D. Bieniasz PLoS Pathog. 2009 February; 5(2): e1000300. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000300.PMCID: PMC2633611 Arabidopsis CaM Binding Protein CBP60g Contributes to MAMP-Induced SA Accumulation and Is Involved in Disease Resistance against Pseudomonas syringae Lin Wang, Kenichi Tsuda, Masanao Sato, Jerry D. Cohen, Fumiaki Katagiri, and Jane Glazebrook PLoS Pathog. 2009 February; 5(2): e1000301. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000301.PMCID: PMC2633612 The Glutathione Biosynthetic Pathway of Plasmodium Is Essential for Mosquito Transmission Joel Vega-Rodríguez, Blandine Franke-Fayard, Rhoel R. Dinglasan, Chris J. Janse, Rebecca Pastrana-Mena, Andrew P. Waters, Isabelle Coppens, José F. Rodríguez-Orengo, Marcelo Jacobs-Lorena, and Adelfa E. Serrano PLoS Pathog. 2009 February; 5(2): e1000302. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000302.PMCID: PMC2636896 Type 1 Fimbriae, a Colonization Factor of Uropathogenic Escherichia coli, Are Controlled by the Metabolic Sensor CRP-cAMP Claudia M. Müller, Anna Åberg, Jurate Straseviçiene, Levente Emődy, Bernt Eric Uhlin, and Carlos Balsalobre PLoS Pathog. 2009 February; 5(2): e1000303. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000303.PMCID: PMC2636892 Differential Ligand Binding to a Human Cytomegalovirus Chemokine Receptor Determines Cell Type–Specific Motility Jennifer Vomaske, Ryan M. Melnychuk, Patricia P. Smith, Joshua Powell, Laurel Hall, Victor DeFilippis, Klaus Früh, Martine Smit, David D. Schlaepfer, Jay A. Nelson, and Daniel N. Streblow PLoS Pathog. 2009 February; 5(2): e1000304. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000304.PMCID: PMC2637432 Quantitative Metabolomics Reveals an Epigenetic Blueprint for Iron Acquisition in Uropathogenic Escherichia coli Jeffrey P. Henderson, Jan R. Crowley, Jerome S. Pinkner, Jennifer N. Walker, Pablo Tsukayama, Walter E. Stamm, Thomas M. Hooton, and Scott J. Hultgren PLoS Pathog. 2009 February; 5(2): e1000305. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000305.PMCID: PMC2637984 Coordinated Regulation of Virulence during Systemic Infection of Salmonella enterica Serovar Typhimurium Hyunjin Yoon, Jason E. McDermott, Steffen Porwollik, Michael McClelland, and Fred Heffron PLoS Pathog. 2009 February; 5(2): e1000306. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000306.PMCID: PMC2639726 The Plasmodium falciparum STEVOR Multigene Family Mediates Antigenic Variation of the Infected Erythrocyte Makhtar Niang, Xue Yan Yam, and Peter Rainer Preiser PLoS Pathog. 2009 February; 5(2): e1000307. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000307.PMCID: PMC2637975 A Rapid Crosstalk of Human γδ T Cells and Monocytes Drives the Acute Inflammation in Bacterial Infections Matthias Eberl, Gareth W. Roberts, Simone Meuter, John D. Williams, Nicholas Topley, and Bernhard Moser PLoS Pathog. 2009 February; 5(2): e1000308. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000308.PMCID: PMC2637987 Export of a Toxoplasma gondii Rhoptry Neck Protein Complex at the Host Cell Membrane to Form the Moving Junction during Invasion Sébastien Besteiro, Adeline Michelin, Joël Poncet, Jean-François Dubremetz, and Maryse Lebrun PLoS Pathog. 2009 February; 5(2): e1000309. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000309.PMCID: PMC2642630 Receptor Complementation and Mutagenesis Reveal SR-BI as an Essential
HCV Entry Factor and Functionally Imply Its Intra- and Extra-Cellular Domains Marlène Dreux, Viet Loan Dao Thi, Judith Fresquet, Maryse Guérin, Zélie Julia, Géraldine Verney, David Durantel, Fabien Zoulim, Dimitri Lavillette, François-Loïc Cosset, and Birke Bartosch PLoS Pathog. 2009 February; 5(2): e1000310. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000310.PMCID: PMC2636890 An Antiviral Response Directed by PKR Phosphorylation of the RNA Helicase A Anthony J. Sadler, Olivier Latchoumanin, David Hawkes, Johnson Mak, and Bryan R. G. Williams PLoS Pathog. 2009 February; 5(2): e1000311. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000311.PMCID: PMC2637979 Molecular Evolution of a Viral Non-Coding Sequence under the Selective Pressure of amiRNA-Mediated Silencing Shih-Shun Lin, Hui-Wen Wu, Santiago F. Elena, Kuan-Chun Chen, Qi-Wen Niu, Shyi-Dong Yeh, Chin-Chih Chen, and Nam-Hai Chua PLoS Pathog. 2009 February; 5(2): e1000312. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000312.PMCID: PMC2642722 Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade Nobuhiro Nakamoto, Hyosun Cho, Abraham Shaked, Kim Olthoff, Mary E. Valiga, Mary Kaminski, Emma Gostick, David A. Price, Gordon J. Freeman, E. John Wherry, and Kyong-Mi Chang PLoS Pathog. 2009 February; 5(2): e1000313. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000313.PMCID: PMC2642724 Extracellular Bacterial Pathogen Induces Host Cell Surface Reorganization to Resist Shear Stress Guillain Mikaty, Magali Soyer, Emilie Mairey, Nelly Henry, Dave Dyer, Katrina T. Forest, Philippe Morand, Stéphanie Guadagnini, Marie Christine Prévost, Xavier Nassif, and Guillaume Duménil PLoS Pathog. 2009 February; 5(2): e1000314. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000314.PMCID: PMC2642725 Toll-Like Receptor 3 (TLR3) Plays a Major Role in the Formation of Rabies Virus Negri Bodies Pauline Ménager, Pascal Roux, Françoise Mégret, Jean-Pierre Bourgeois, Anne-Marie Le Sourd, Anne Danckaert, Mireille Lafage, Christophe Préhaud, and Monique Lafon PLoS Pathog. 2009 February; 5(2): e1000315. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000315.PMCID: PMC2642728 Interpain A, a Cysteine Proteinase from Prevotella intermedia, Inhibits Complement by Degrading Complement Factor C3 Michal Potempa, Jan Potempa, Tomasz Kantyka, Ky-Anh Nguyen, Katarzyna Wawrzonek, Surya P. Manandhar, Katarzyna Popadiak, Kristian Riesbeck, Sigrun Eick, and Anna M. Blom PLoS Pathog. 2009 February; 5(2): e1000316. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000316.PMCID: PMC2642729 Differential Trypanosome Surface Coat Regulation by a CCCH Protein That Co-Associates with procyclin mRNA cis-Elements Pegine Walrad, Athina Paterou, Alvaro Acosta-Serrano, and Keith R. Matthews PLoS Pathog. 2009 February; 5(2): e1000317. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000317.PMCID: PMC2642730 Establishment of Human Papillomavirus Infection Requires Cell Cycle Progression Dohun Pyeon, Shane M. Pearce, Simon M. Lank, Paul Ahlquist, and Paul F. Lambert PLoS Pathog. 2009 February; 5(2): e1000318. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000318.PMCID: PMC2642596 Nonrandom Distribution of Vector Ticks (Dermacentor variabilis) Infected by Francisella tularensis Heidi K. Goethert and Sam R. Telford, III PLoS Pathog. 2009 February; 5(2): e1000319. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000319.PMCID: PMC2642597 Modulation of Neutrophil Function by a Secreted Mucinase of Escherichia coli O157 ![[ratio]](corehtml/pmc/pmcents/x2236.gif) H7 Rose L. Szabady, Mary A. Lokuta, Kevin B. Walters, Anna Huttenlocher, and Rodney A. Welch PLoS Pathog. 2009 February; 5(2): e1000320. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000320.PMCID: PMC2642718 Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man Jean K. Lim, Andrea Lisco, David H. McDermott, Linda Huynh, Jerrold M. Ward, Bernard Johnson, Hope Johnson, John Pape, Gregory A. Foster, David Krysztof, Dean Follmann, Susan L. Stramer, Leonid B. Margolis, and Philip M. Murphy PLoS Pathog. 2009 February; 5(2): e1000321. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000321.PMCID: PMC2642680 |