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Volume 5(2);  February 2009
Opinion
Infectious Diseases of the Nervous System and Their Impact in Developing Countries
Roberto Bruzzone, Monique Dubois-Dalcq, Georges E. Grau, Diane E. Griffin, and Krister Kristensson
PLoS Pathog. 2009 February; 5(2): e1000199. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000199.
PMCID: PMC2642628
Research Articles
An RIG-I-Like RNA Helicase Mediates Antiviral RNAi Downstream of Viral siRNA Biogenesis in Caenorhabditis elegans
Rui Lu, Erbay Yigit, Wan-Xiang Li, and Shou-Wei Ding
PLoS Pathog. 2009 February; 5(2): e1000286. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000286.
PMCID: PMC2629121
Rift Valley Fever Virus NSs Protein Promotes Post-Transcriptional Downregulation of Protein Kinase PKR and Inhibits eIF2α Phosphorylation
Tetsuro Ikegami, Krishna Narayanan, Sungyong Won, Wataru Kamitani, C. J. Peters, and Shinji Makino
PLoS Pathog. 2009 February; 5(2): e1000287. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000287.
PMCID: PMC2629125
Disruption of the Toxoplasma gondii Parasitophorous Vacuole by IFNγ-Inducible Immunity-Related GTPases (IRG Proteins) Triggers Necrotic Cell Death
Yang O. Zhao, Aliaksandr Khaminets, Julia P. Hunn, and Jonathan C. Howard
PLoS Pathog. 2009 February; 5(2): e1000288. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000288.
PMCID: PMC2629126
Phthiocerol Dimycocerosates of M. tuberculosis Participate in Macrophage Invasion by Inducing Changes in the Organization of Plasma Membrane Lipids
Catherine Astarie-Dequeker, Laurent Le Guyader, Wladimir Malaga, Fam-Ky Seaphanh, Christian Chalut, André Lopez, and Christophe Guilhot
PLoS Pathog. 2009 February; 5(2): e1000289. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000289.
PMCID: PMC2632888
Pep1, a Secreted Effector Protein of Ustilago maydis, Is Required for Successful Invasion of Plant Cells
Gunther Doehlemann, Karina van der Linde, Daniela Aßmann, Daniela Schwammbach, Alexander Hof, Amitabh Mohanty, David Jackson, and Regine Kahmann
PLoS Pathog. 2009 February; 5(2): e1000290. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000290.
PMCID: PMC2631132
HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice
Michael A. Joyce, Kathie-Anne Walters, Sue-Ellen Lamb, Mathew M. Yeh, Lin-Fu Zhu, Norman Kneteman, Jason S. Doyle, Michael G. Katze, and D. Lorne Tyrrell
PLoS Pathog. 2009 February; 5(2): e1000291. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000291.
PMCID: PMC2647842
Differences in APOBEC3G Expression in CD4+ T Helper Lymphocyte Subtypes Modulate HIV-1 Infectivity
Michael L. Vetter, Megan E. Johnson, Amanda K. Antons, Derya Unutmaz, and Richard T. D'Aquila
PLoS Pathog. 2009 February; 5(2): e1000292. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000292.
PMCID: PMC2631133
Detailed Analysis of Sequence Changes Occurring during vlsE Antigenic Variation in the Mouse Model of Borrelia burgdorferi Infection
Loïc Coutte, Douglas J. Botkin, Lihui Gao, and Steven J. Norris
PLoS Pathog. 2009 February; 5(2): e1000293. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000293.
PMCID: PMC2632889
The Protein Kinase Tor1 Regulates Adhesin Gene Expression in Candida albicans
Robert J. Bastidas, Joseph Heitman, and Maria E. Cardenas
PLoS Pathog. 2009 February; 5(2): e1000294. Published online 2009 February 6. doi: 10.1371/journal.ppat.1000294.
PMCID: PMC2631134
Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection
David Favre, Sharon Lederer, Bittoo Kanwar, Zhong-Min Ma, Sean Proll, Zeljka Kasakow, Jeff Mold, Louise Swainson, Jason D. Barbour, Carole R. Baskin, Robert Palermo, Ivona Pandrea, Christopher J. Miller, Michael G. Katze, and Joseph M. McCune
PLoS Pathog. 2009 February; 5(2): e1000295. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000295.
PMCID: PMC2635016
Transcriptional Profiling in Pathogenic and Non-Pathogenic SIV Infections Reveals Significant Distinctions in Kinetics and Tissue Compartmentalization
Sharon Lederer, David Favre, Kathie-Anne Walters, Sean Proll, Bittoo Kanwar, Zeljka Kasakow, Carole R. Baskin, Robert Palermo, Joseph M. McCune, and Michael G. Katze
PLoS Pathog. 2009 February; 5(2): e1000296. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000296.
PMCID: PMC2633618
The Macrophage Scavenger Receptor A Is Host-Protective in Experimental Meningococcal Septicaemia
Annette Plüddemann, J. Claire Hoe, Katherine Makepeace, E. Richard Moxon, and Siamon Gordon
PLoS Pathog. 2009 February; 5(2): e1000297. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000297.
PMCID: PMC2633608
Myd88 Is Required for an Antibody Response to Retroviral Infection
Edward P. Browne and Dan R. Littman
PLoS Pathog. 2009 February; 5(2): e1000298. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000298.
PMCID: PMC2633609
Dengue Virus Type 2 Infections of Aedes aegypti Are Modulated by the Mosquito's RNA Interference Pathway
Irma Sánchez-Vargas, Jaclyn C. Scott, B. Katherine Poole-Smith, Alexander W. E. Franz, Valérie Barbosa-Solomieu, Jeffrey Wilusz, Ken E. Olson, and Carol D. Blair
PLoS Pathog. 2009 February; 5(2): e1000299. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000299.
PMCID: PMC2633610
Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain Variants
Matthew W. McNatt, Trinity Zang, Theodora Hatziioannou, Mackenzie Bartlett, Ismael Ben Fofana, Welkin E. Johnson, Stuart J. D. Neil, and Paul D. Bieniasz
PLoS Pathog. 2009 February; 5(2): e1000300. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000300.
PMCID: PMC2633611
Arabidopsis CaM Binding Protein CBP60g Contributes to MAMP-Induced SA Accumulation and Is Involved in Disease Resistance against Pseudomonas syringae
Lin Wang, Kenichi Tsuda, Masanao Sato, Jerry D. Cohen, Fumiaki Katagiri, and Jane Glazebrook
PLoS Pathog. 2009 February; 5(2): e1000301. Published online 2009 February 13. doi: 10.1371/journal.ppat.1000301.
PMCID: PMC2633612
The Glutathione Biosynthetic Pathway of Plasmodium Is Essential for Mosquito Transmission
Joel Vega-Rodríguez, Blandine Franke-Fayard, Rhoel R. Dinglasan, Chris J. Janse, Rebecca Pastrana-Mena, Andrew P. Waters, Isabelle Coppens, José F. Rodríguez-Orengo, Marcelo Jacobs-Lorena, and Adelfa E. Serrano
PLoS Pathog. 2009 February; 5(2): e1000302. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000302.
PMCID: PMC2636896
Type 1 Fimbriae, a Colonization Factor of Uropathogenic Escherichia coli, Are Controlled by the Metabolic Sensor CRP-cAMP
Claudia M. Müller, Anna Åberg, Jurate Straseviçiene, Levente Emődy, Bernt Eric Uhlin, and Carlos Balsalobre
PLoS Pathog. 2009 February; 5(2): e1000303. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000303.
PMCID: PMC2636892
Differential Ligand Binding to a Human Cytomegalovirus Chemokine Receptor Determines Cell Type–Specific Motility
Jennifer Vomaske, Ryan M. Melnychuk, Patricia P. Smith, Joshua Powell, Laurel Hall, Victor DeFilippis, Klaus Früh, Martine Smit, David D. Schlaepfer, Jay A. Nelson, and Daniel N. Streblow
PLoS Pathog. 2009 February; 5(2): e1000304. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000304.
PMCID: PMC2637432
Quantitative Metabolomics Reveals an Epigenetic Blueprint for Iron Acquisition in Uropathogenic Escherichia coli
Jeffrey P. Henderson, Jan R. Crowley, Jerome S. Pinkner, Jennifer N. Walker, Pablo Tsukayama, Walter E. Stamm, Thomas M. Hooton, and Scott J. Hultgren
PLoS Pathog. 2009 February; 5(2): e1000305. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000305.
PMCID: PMC2637984
Coordinated Regulation of Virulence during Systemic Infection of Salmonella enterica Serovar Typhimurium
Hyunjin Yoon, Jason E. McDermott, Steffen Porwollik, Michael McClelland, and Fred Heffron
PLoS Pathog. 2009 February; 5(2): e1000306. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000306.
PMCID: PMC2639726
The Plasmodium falciparum STEVOR Multigene Family Mediates Antigenic Variation of the Infected Erythrocyte
Makhtar Niang, Xue Yan Yam, and Peter Rainer Preiser
PLoS Pathog. 2009 February; 5(2): e1000307. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000307.
PMCID: PMC2637975
A Rapid Crosstalk of Human γδ T Cells and Monocytes Drives the Acute Inflammation in Bacterial Infections
Matthias Eberl, Gareth W. Roberts, Simone Meuter, John D. Williams, Nicholas Topley, and Bernhard Moser
PLoS Pathog. 2009 February; 5(2): e1000308. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000308.
PMCID: PMC2637987
Export of a Toxoplasma gondii Rhoptry Neck Protein Complex at the Host Cell Membrane to Form the Moving Junction during Invasion
Sébastien Besteiro, Adeline Michelin, Joël Poncet, Jean-François Dubremetz, and Maryse Lebrun
PLoS Pathog. 2009 February; 5(2): e1000309. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000309.
PMCID: PMC2642630
Receptor Complementation and Mutagenesis Reveal SR-BI as an Essential HCV Entry Factor and Functionally Imply Its Intra- and Extra-Cellular Domains
Marlène Dreux, Viet Loan Dao Thi, Judith Fresquet, Maryse Guérin, Zélie Julia, Géraldine Verney, David Durantel, Fabien Zoulim, Dimitri Lavillette, François-Loïc Cosset, and Birke Bartosch
PLoS Pathog. 2009 February; 5(2): e1000310. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000310.
PMCID: PMC2636890
An Antiviral Response Directed by PKR Phosphorylation of the RNA Helicase A
Anthony J. Sadler, Olivier Latchoumanin, David Hawkes, Johnson Mak, and Bryan R. G. Williams
PLoS Pathog. 2009 February; 5(2): e1000311. Published online 2009 February 20. doi: 10.1371/journal.ppat.1000311.
PMCID: PMC2637979
Molecular Evolution of a Viral Non-Coding Sequence under the Selective Pressure of amiRNA-Mediated Silencing
Shih-Shun Lin, Hui-Wen Wu, Santiago F. Elena, Kuan-Chun Chen, Qi-Wen Niu, Shyi-Dong Yeh, Chin-Chih Chen, and Nam-Hai Chua
PLoS Pathog. 2009 February; 5(2): e1000312. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000312.
PMCID: PMC2642722
Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade
Nobuhiro Nakamoto, Hyosun Cho, Abraham Shaked, Kim Olthoff, Mary E. Valiga, Mary Kaminski, Emma Gostick, David A. Price, Gordon J. Freeman, E. John Wherry, and Kyong-Mi Chang
PLoS Pathog. 2009 February; 5(2): e1000313. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000313.
PMCID: PMC2642724
Extracellular Bacterial Pathogen Induces Host Cell Surface Reorganization to Resist Shear Stress
Guillain Mikaty, Magali Soyer, Emilie Mairey, Nelly Henry, Dave Dyer, Katrina T. Forest, Philippe Morand, Stéphanie Guadagnini, Marie Christine Prévost, Xavier Nassif, and Guillaume Duménil
PLoS Pathog. 2009 February; 5(2): e1000314. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000314.
PMCID: PMC2642725
Toll-Like Receptor 3 (TLR3) Plays a Major Role in the Formation of Rabies Virus Negri Bodies
Pauline Ménager, Pascal Roux, Françoise Mégret, Jean-Pierre Bourgeois, Anne-Marie Le Sourd, Anne Danckaert, Mireille Lafage, Christophe Préhaud, and Monique Lafon
PLoS Pathog. 2009 February; 5(2): e1000315. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000315.
PMCID: PMC2642728
Interpain A, a Cysteine Proteinase from Prevotella intermedia, Inhibits Complement by Degrading Complement Factor C3
Michal Potempa, Jan Potempa, Tomasz Kantyka, Ky-Anh Nguyen, Katarzyna Wawrzonek, Surya P. Manandhar, Katarzyna Popadiak, Kristian Riesbeck, Sigrun Eick, and Anna M. Blom
PLoS Pathog. 2009 February; 5(2): e1000316. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000316.
PMCID: PMC2642729
Differential Trypanosome Surface Coat Regulation by a CCCH Protein That Co-Associates with procyclin mRNA cis-Elements
Pegine Walrad, Athina Paterou, Alvaro Acosta-Serrano, and Keith R. Matthews
PLoS Pathog. 2009 February; 5(2): e1000317. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000317.
PMCID: PMC2642730
Establishment of Human Papillomavirus Infection Requires Cell Cycle Progression
Dohun Pyeon, Shane M. Pearce, Simon M. Lank, Paul Ahlquist, and Paul F. Lambert
PLoS Pathog. 2009 February; 5(2): e1000318. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000318.
PMCID: PMC2642596
Nonrandom Distribution of Vector Ticks (Dermacentor variabilis) Infected by Francisella tularensis
Heidi K. Goethert and Sam R. Telford, III
PLoS Pathog. 2009 February; 5(2): e1000319. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000319.
PMCID: PMC2642597
Modulation of Neutrophil Function by a Secreted Mucinase of Escherichia coli O157[ratio]H7
Rose L. Szabady, Mary A. Lokuta, Kevin B. Walters, Anna Huttenlocher, and Rodney A. Welch
PLoS Pathog. 2009 February; 5(2): e1000320. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000320.
PMCID: PMC2642718
Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man
Jean K. Lim, Andrea Lisco, David H. McDermott, Linda Huynh, Jerrold M. Ward, Bernard Johnson, Hope Johnson, John Pape, Gregory A. Foster, David Krysztof, Dean Follmann, Susan L. Stramer, Leonid B. Margolis, and Philip M. Murphy
PLoS Pathog. 2009 February; 5(2): e1000321. Published online 2009 February 27. doi: 10.1371/journal.ppat.1000321.
PMCID: PMC2642680
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