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Sponsors and Collaborators: |
National Taiwan University Hospital National Science Council, Taiwan |
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Information provided by: | National Taiwan University Hospital |
ClinicalTrials.gov Identifier: | NCT00155311 |
To test whether levels of OPG can be changed during orthodontic treatment. Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different period of time in volunteers. In situ hybridization and immunohistochemistry analysis for OPG and RANKL will reveal their roles in this physiological process.
Condition | Intervention | Phase |
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Malocclusion |
Procedure: orthodontic treatment |
Phase I |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Single Blind, Active Control, Factorial Assignment, Efficacy Study |
Estimated Enrollment: | 12 |
Study Start Date: | January 2005 |
Estimated Study Completion Date: | December 2006 |
Long treatment time is a major factor causing high fee for orthodontic treatment. Patients would have dental caries or periodontitis resulted from improper oral hygiene care during this long treatment period. Therefore, how to speed up the tooth movement which determines the duration of orthodontic treatment, can help more people to obtain good occlusion and esthetics. Orthodontic force on tooth induces bone resorption on the compression side and bone deposition on the tension side, thus bone remodels and then tooth moves. Bone resorption is a complex process. Osteoblasts play an important role during initiation of bone resorption. Changes OPG expression of osteoblasts under mechanical stimulation can play a role in bone remodeling. In order to test this hypothesis, the following specific aims will be achieved:
Ages Eligible for Study: | 18 Years to 35 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Chung-Chen Yao, DDS, PhD | 886-2-23123456 ext 7689 | janeyao@ha.mc.ntu.edu.tw |
Taiwan | |
Department of Dentistry, National Taiwan University Hospital | Recruiting |
Taipei, Taiwan | |
Contact: Wan-Hon Lan, DDS, PhD 886-2-23123456 ext 2148 | |
Principal Investigator: Chung-Chen Yao, DDS, PhD |
Principal Investigator: | Chung-Chen Yao, DDS, PhD | National Taiwan University Hospital |
Study ID Numbers: | 9361700741 |
Study First Received: | September 8, 2005 |
Last Updated: | November 25, 2005 |
ClinicalTrials.gov Identifier: | NCT00155311 History of Changes |
Health Authority: | Taiwan: Department of Health |
orthodontic tooth movement OPG RANKL |
Tooth Diseases Malocclusion Stomatognathic Diseases |
Tooth Diseases Malocclusion Stomatognathic Diseases |