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Sponsored by: |
Yokohama City University Medical Center |
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Information provided by: | Yokohama City University Medical Center |
ClinicalTrials.gov Identifier: | NCT00298129 |
Many patients with chronic renal disease show a loss of the nocturnal decline of blood pressure (non-dipper). However, the mechanism is not yet fully understood. We evaluate 24-hour blood pressure in patients with chronic renal disease using an ambulatory blood pressure monitoring device (A & D TM2425). We also analyze the power spectrum of heart rate variability as an index of autonomic cardiovascular modulation using the same device.
Condition | Intervention |
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Diabetes Mellitus Essential Hypertension Renal Failure Chronic Nephropathy |
Device: Ambulatory blood pressure monitoring |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Convenience Sample, Prospective Study |
Official Title: | Autonomic Imbalance and 24-h Blood Pressure Change in Patients With Chronic Renal Disease |
Enrollment: | 278 |
Study Start Date: | February 2004 |
Study Completion Date: | December 2006 |
The ratio of lower frequency (LF) and higher frequency (HF) heart rate rhythmic oscillations is expressed as an index of sympathovagal balance.
Patients with chronic renal disease participate in the study. Blood pressure and power spectrum of heart rate variability for 24 hours are measured when they receive no medication for at least 1 week. The mean waking and sleeping time systolic and diastolic blood pressure are calculated. LF/HF ratios in the chronic renal disease are evaluated to calculate the waking/sleeping ratio for LF/HF.
Ages Eligible for Study: | 20 Years to 85 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Japan | |
Yokohama City University Center Hospital | |
Yokohama, Japan, 232-0024 |
Principal Investigator: | Gen Yasuda, MD | Yokohama City University Center Hospital |
Principal Investigator: | Gen Yasuda, MD | Yokohama City University Center Hospital |
Principal Investigator: | Gen Yasuda, MD | Yokohama City University Center Hospital |
Study ID Numbers: | 7332-3 |
Study First Received: | February 28, 2006 |
Last Updated: | May 8, 2007 |
ClinicalTrials.gov Identifier: | NCT00298129 History of Changes |
Health Authority: | Japan: Ministry of Health, Labor and Welfare |
Renal Insufficiency Essential Hypertension Metabolic Diseases Kidney Failure, Chronic Diabetes Mellitus Vascular Diseases Endocrine System Diseases Urologic Diseases |
Renal Insufficiency, Chronic Endocrinopathy Kidney Diseases Glucose Metabolism Disorders Metabolic Disorder Kidney Failure Hypertension |
Renal Insufficiency Metabolic Diseases Diabetes Mellitus Kidney Failure, Chronic Vascular Diseases Endocrine System Diseases Urologic Diseases |
Renal Insufficiency, Chronic Cardiovascular Diseases Kidney Diseases Glucose Metabolism Disorders Hypertension Kidney Failure |