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Sponsors and Collaborators: |
Pediatric Brain Tumor Consortium National Cancer Institute (NCI) |
---|---|
Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00010114 |
RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer.
PURPOSE: Genetic study to learn more about genes involved in the development of central nervous system tumors in young children.
Condition | Intervention |
---|---|
Brain and Central Nervous System Tumors |
Genetic: comparative genomic hybridization Genetic: microarray analysis |
Study Type: | Observational |
Official Title: | Gene Expression Profiling of Infant Embryonal Central Nervous System Tumors by Microarray Gene Chip Analysis: Angiogenesis, Invasion and Metastasis |
Study Start Date: | March 2001 |
OBJECTIVES:
OUTLINE: This is a multicenter study.
Tumor samples are analyzed using microarray gene chip analysis. Differentially expressed genes are evaluated for protein expression by standard immunohistochemistry and/or Western blot analysis, and gene expression is further quantified by semi-quantitative polymerase chain reaction.
PROJECTED ACCRUAL: Approximately 80-100 patients (20-25 with metastatic disease and 60-75 with non-metastatic disease) will be accrued for this study within 4-5 years.
Ages Eligible for Study: | up to 2 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Histologically confirmed, newly diagnosed, primary intracranial embryonal central nervous system tumor
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy:
Surgery:
Other:
United States, California | |
UCSF Cancer Center and Cancer Research Institute | |
San Francisco, California, United States, 94143-0128 | |
United States, District of Columbia | |
Children's National Medical Center | |
Washington, District of Columbia, United States, 20010-2970 | |
United States, Massachusetts | |
Dana-Farber Cancer Institute | |
Boston, Massachusetts, United States, 02115 | |
United States, North Carolina | |
Duke Comprehensive Cancer Center | |
Durham, North Carolina, United States, 27710 | |
United States, Pennsylvania | |
Children's Hospital of Philadelphia | |
Philadelphia, Pennsylvania, United States, 19104 | |
Children's Hospital of Pittsburgh | |
Pittsburgh, Pennsylvania, United States, 15213 | |
United States, Tennessee | |
Saint Jude Children's Research Hospital | |
Memphis, Tennessee, United States, 38105-2794 | |
United States, Texas | |
Baylor College of Medicine | |
Houston, Texas, United States, 77030 | |
United States, Washington | |
Children's Hospital and Regional Medical Center - Seattle | |
Seattle, Washington, United States, 98105 |
Study Chair: | Tobey MacDonald, MD | Children's Research Institute |
Study ID Numbers: | CDR0000068446, PBTC-N04 |
Study First Received: | February 2, 2001 |
Last Updated: | February 14, 2009 |
ClinicalTrials.gov Identifier: | NCT00010114 History of Changes |
Health Authority: | United States: Federal Government |
childhood central nervous system germ cell tumor childhood choroid plexus tumor untreated childhood supratentorial primitive neuroectodermal tumor untreated childhood medulloblastoma newly diagnosed childhood ependymoma |
Choroid Plexus Neoplasms Neuroectodermal Tumors Neuroectodermal Tumors, Primitive Medulloblastoma Neoplasm Metastasis |
Neuroepithelioma Central Nervous System Neoplasms Ependymoma Nervous System Neoplasms |
Neoplasms Neoplasms by Site Nervous System Diseases Central Nervous System Neoplasms Nervous System Neoplasms |