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Sponsored by: |
National Center for Research Resources (NCRR) |
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Information provided by: | National Center for Research Resources (NCRR) |
ClinicalTrials.gov Identifier: | NCT00011141 |
The etiology of immune-mediated diabetes mellitus (IMD) remains unclear. However, previous studies indicate that autoimmunity may be a result of dysfunction of natural killer T cells (NK-T cells). Newly diagnoses patients with IMD have been shown in our laboratory to have significantly lower NK-T cells than normal controls. Other studies have shown that oral administration of lactobacillus can boost NK-T cell activity in children with HIV without side effects. Our objective is to evaluate the effect of lactobacillus administration on NK-T cell activity in patients with IMD
Condition | Intervention |
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Diabetes Mellitus |
Drug: Oral lactobacillus administration |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Efficacy Study |
Official Title: | Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency |
Ages Eligible for Study: | 1 Year to 95 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Recently diagnosed (within the last 6 months) patients with immune-mediated (type 1) diabetes
Study ID Numbers: | NCRR-M01RR06020-0165 |
Study First Received: | February 12, 2001 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00011141 History of Changes |
Health Authority: | United States: Federal Government |
Immune-mediated diabetes mellitus |
Immune Defect Due to Absence of Thymus Metabolic Diseases Diabetes Mellitus Endocrine System Diseases |
Endocrinopathy Glucose Metabolism Disorders Metabolic Disorder |
Metabolic Diseases Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders |