Strain-Encoded Magnetic Resonance Imaging in Acute Myocardial Infarction - Full Text View

Sponsors and Collaborators:	RWTH Aachen University University of Heidelberg
Information provided by:	RWTH Aachen University
ClinicalTrials.gov Identifier:	NCT00752713

Purpose

The aim of the study was therefore to evaluate whether myocardial deformation imaging performed by SENC allows for quantification of regional left ventricular function and is related to transmurality states of infarcted tissue in patients with acute myocardial infarction (AMI).

Condition	Intervention
Acute Myocardial Infarction	Procedure: cardiac MRI

MedlinePlus related topics: Heart Attack MRI Scans

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case Control, Prospective
Official Title:	Strain-Encoded Magnetic Resonance Imaging for Evaluation of Left Ventricular Function and Acute Myocardial Infarction

Further study details as provided by RWTH Aachen University:

Primary Outcome Measures:

Left ventricular function [ Time Frame: 01.01.2007 until 01.02.2007 ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Transmurality [ Time Frame: 01.01.2007 until 01.02.2007 ] [ Designated as safety issue: No ]

Biospecimen Retention: None Retained

Biospecimen Description:

Enrollment:	48
Study Start Date:	January 2007
Study Completion Date:	January 2008
Primary Completion Date:	January 2008 (Final data collection date for primary outcome measure)

Groups/Cohorts	Assigned Interventions
1 Patients presenting to hospital with AMI	Procedure: cardiac MRI cardiac MRI at one time point for group 1 after intervention for group 2 at any time point
2 healthy volunteers as control group	Procedure: cardiac MRI cardiac MRI at one time point for group 1 after intervention for group 2 at any time point

Detailed Description:

CMR was performed in 38 consecutive patients with AMI 3±1 days after successful reperfusion using a clinical 1.5 Tesla MR-scanner. Ten healthy volunteers served as controls. SENC is a technique that directly measures peak circumferential strain from long-axis views and peak longitudinal strain from short axis views. Measurements were obtained for each segment in a modified 17 segment model. Wall motion and infarcted tissue were evaluated semi-quantitatively from SSFP cine sequences and contrast-enhanced-MR-images and were then related to myocardial strain. Comparison of peak circumferential strain assessed by SENC and MR-tagging was performed.

Eligibility

Ages Eligible for Study:	30 Years to 80 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Consecutive Patients with AMI 3+/-1 days after successful reperfusion
Ten healthy volunteers serving as control group

Criteria

Inclusion Criteria:

Patients with AMI after successful reperfusion
Healthy volunteers in control group

Exclusion Criteria:

No reperfusion

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00752713

Locations

Germany
University Hospital Heidelberg
Heidelberg, Germany, 69120

Sponsors and Collaborators

RWTH Aachen University

University of Heidelberg

Investigators

Principal Investigator:

Mirja Neizel, MD

University Hospital Heidelberg

More Information

No publications provided

Responsible Party:	Medical Clinic III, University Hospital Heidelberg ( Mirja Neizel, MD )
Study ID Numbers:	SENC in AMI
Study First Received:	September 11, 2008
Last Updated:	September 15, 2008
ClinicalTrials.gov Identifier:	NCT00752713 History of Changes
Health Authority:	Germany: Federal Institute for Drugs and Medical Devices

Keywords provided by RWTH Aachen University:

AMI,
Reperfusion
successful
reperfusion

Study placed in the following topic categories:

Necrosis
Heart Diseases
Myocardial Ischemia
Vascular Diseases

Ischemia
Infarction
Myocardial Infarction

Additional relevant MeSH terms:

Necrosis
Heart Diseases
Pathologic Processes
Myocardial Ischemia
Vascular Diseases

Cardiovascular Diseases
Ischemia
Infarction
Myocardial Infarction

ClinicalTrials.gov processed this record on May 07, 2009