Preoperative NSAID to Colorectal Cancer Patients - Full Text View

Sponsored by:	Göteborg University
Information provided by:	Göteborg University
ClinicalTrials.gov Identifier:	NCT00473980

Purpose

The study is designed to evaluate effects of NSAIDs on immune activity inside and close to tumor tissue in patients with colorectal cancer.

Condition	Intervention	Phase
Colorectal Cancer	Drug: Indomethacin, celecoxib, esomeprazole	Phase IV

MedlinePlus related topics: Cancer Colorectal Cancer

Drug Information available for: Indomethacin Omeprazole Omeprazole magnesium Esomeprazole Sodium Esomeprazole magnesium Celecoxib

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study
Official Title:	Preoperative Treatment With NSAID in Colorectal Cancer Patients in Relationship to Tumor Host Reactions

Further study details as provided by Göteborg University:

Primary Outcome Measures:

Immune reactivity [ Time Frame: Acute evaluations ]

Enrollment:	28
Study Start Date:	December 1998
Study Completion Date:	May 2007

Detailed Description:

Study and control patients are randomized to receive preoperative treatment with indomethacin or celecoxib compared to sham treatment.Tumor biopsies are taken at operation and used for analyses of tumor immunity and gene expression.

Eligibility

Ages Eligible for Study:	40 Years to 80 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Colon carcinoma scheduled for curative operation

Exclusion Criteria:

Diabetes, steroid medication, liver and kidney impairment

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00473980

Locations

Sweden
Department of Surgery
Göteborg, Sweden, SE 41345

Sponsors and Collaborators

Göteborg University

Investigators

Principal Investigator:

Kent Lundholm, MD, prof

Göteborg University

More Information

Additional Information:

Göteborg University This link exits the ClinicalTrials.gov site

No publications provided

Study ID Numbers:	kl4501122
Study First Received:	May 15, 2007
Last Updated:	May 15, 2007
ClinicalTrials.gov Identifier:	NCT00473980 History of Changes
Health Authority:	Sweden: The National Board of Health and Welfare

Keywords provided by Göteborg University:

MHC
CTLs
Colon carcinoma
NSAID
Survival

Study placed in the following topic categories:

Anti-Inflammatory Agents
Digestive System Neoplasms
Celecoxib
Gastrointestinal Diseases
Cyclooxygenase Inhibitors
Colonic Diseases
Omeprazole
Cardiovascular Agents
Intestinal Diseases
Rectal Diseases
Intestinal Neoplasms

Carcinoma
Digestive System Diseases
Analgesics, Non-Narcotic
Indomethacin
Gastrointestinal Neoplasms
Anti-Inflammatory Agents, Non-Steroidal
Peripheral Nervous System Agents
Analgesics
Antirheumatic Agents
Colorectal Neoplasms

Additional relevant MeSH terms:

Anti-Inflammatory Agents
Molecular Mechanisms of Pharmacological Action
Gastrointestinal Diseases
Colonic Diseases
Physiological Effects of Drugs
Omeprazole
Reproductive Control Agents
Rectal Diseases
Gout Suppressants
Neoplasms by Site
Tocolytic Agents
Sensory System Agents
Therapeutic Uses
Anti-Ulcer Agents
Indomethacin

Anti-Inflammatory Agents, Non-Steroidal
Analgesics
Digestive System Neoplasms
Cyclooxygenase Inhibitors
Gastrointestinal Agents
Enzyme Inhibitors
Cardiovascular Agents
Intestinal Diseases
Intestinal Neoplasms
Pharmacologic Actions
Neoplasms
Digestive System Diseases
Analgesics, Non-Narcotic
Gastrointestinal Neoplasms
Peripheral Nervous System Agents

ClinicalTrials.gov processed this record on May 06, 2009