The Regulation of Osteoprotegerin by Mechanical Stimulation

This study is currently recruiting participants.

Verified by National Taiwan University Hospital, June 2004

First Received: September 8, 2005 Last Updated: November 25, 2005 History of Changes

Sponsors and Collaborators:	National Taiwan University Hospital National Science Council, Taiwan
Information provided by:	National Taiwan University Hospital
ClinicalTrials.gov Identifier:	NCT00155311

Purpose

To test whether levels of OPG can be changed during orthodontic treatment. Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different period of time in volunteers. In situ hybridization and immunohistochemistry analysis for OPG and RANKL will reveal their roles in this physiological process.

Condition	Intervention	Phase
Malocclusion	Procedure: orthodontic treatment	Phase I

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Non-Randomized, Single Blind, Active Control, Factorial Assignment, Efficacy Study

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:

Tissue staining of antibody

Estimated Enrollment:	12
Study Start Date:	January 2005
Estimated Study Completion Date:	December 2006

Detailed Description:

Long treatment time is a major factor causing high fee for orthodontic treatment. Patients would have dental caries or periodontitis resulted from improper oral hygiene care during this long treatment period. Therefore, how to speed up the tooth movement which determines the duration of orthodontic treatment, can help more people to obtain good occlusion and esthetics. Orthodontic force on tooth induces bone resorption on the compression side and bone deposition on the tension side, thus bone remodels and then tooth moves. Bone resorption is a complex process. Osteoblasts play an important role during initiation of bone resorption. Changes OPG expression of osteoblasts under mechanical stimulation can play a role in bone remodeling. In order to test this hypothesis, the following specific aims will be achieved:

To test whether levels of OPG can be changed during orthodontic treatment. Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different period of time in volunteers. In situ hybridization and immunohistochemistry analysis for OPG and RANKL will reveal their roles in this physiological process.
To optimize the regulation by changing magnitude and frequency of pressure, and characterize the time table for these changes..

Eligibility

Ages Eligible for Study:	18 Years to 35 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

patients with two mandibular impaction third molars containing at least one mesially angular impaction with crown exposed to the oral cavity

Exclusion Criteria:

pregnancy or diseases with abnormal bone metabolism

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00155311

Contacts

Contact: Chung-Chen Yao, DDS, PhD

886-2-23123456 ext 7689

janeyao@ha.mc.ntu.edu.tw

Locations

Taiwan
Department of Dentistry, National Taiwan University Hospital	Recruiting
Taipei, Taiwan
Contact: Wan-Hon Lan, DDS, PhD 886-2-23123456 ext 2148
Principal Investigator: Chung-Chen Yao, DDS, PhD

Sponsors and Collaborators

National Taiwan University Hospital

National Science Council, Taiwan

Investigators

Principal Investigator:

Chung-Chen Yao, DDS, PhD

National Taiwan University Hospital

More Information

No publications provided

Study ID Numbers:	9361700741
Study First Received:	September 8, 2005
Last Updated:	November 25, 2005
ClinicalTrials.gov Identifier:	NCT00155311 History of Changes
Health Authority:	Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:

orthodontic tooth movement
OPG
RANKL

Study placed in the following topic categories:

Tooth Diseases
Malocclusion
Stomatognathic Diseases

Additional relevant MeSH terms:

Tooth Diseases
Malocclusion
Stomatognathic Diseases

ClinicalTrials.gov processed this record on May 06, 2009