Mass Spectrometry GroupLeesa J. Deterding, Ph.D.
Staff Scientist Tel (919) 541-3009 Fax (919) 541-0220 deterdi2@niehs.nih.gov P.O. Box 12233 Mail Drop F0-03 Research Triangle Park, North Carolina 27709 Delivery Instructions My major research interests are primarily focused on the application of mass spectrometric techniques to questions in structural biology. Most recently, the focus of my research efforts are directed to understanding the mechanisms for the development of the autoimmune disease, Sjogren�s syndrome. These studies involve the tertiary structural characterization of the antigens associated with this autoimmune disease and their interactions with other biomolecules. As an extension of this work, quantitative proteomics of patient samples are being investigated in an effort to discover biomarkers for the early diagnosis, prognosis and treatment of this disease. Additionally, my research efforts include characterization of the tertiary structure of proteins, determination of the sites of in vitro and in vivo modifications of proteins, the interactions of proteins with other biomolecules and the identification of protein complexes via immunoprecipitates. Collectively, mass spectrometric-based approaches are currently being applied to the following research areas:
Leesa J. Deterding, Ph.D., is a staff scientist in the Mass Spectrometry Group within the Laboratory of Structural Biology. She earned her B.A. degree in chemistry and math from Hastings College, her M.S. degree in chemistry from the University of Nebraska-Lincoln and a Ph.D. in chemistry from North Carolina State University. |
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