Sonia Vasil, Rama Thakallapally, Satish Pillai, Carla Kuiken
T10, MS K710, Los Alamos National Laboratory, Los Alamos, NM 87545.
Acknowledgements
We gratefully acknowledge the help of Drs. Jim Bradac and Alan Schultz from NIAID for invaluable background information and helpful suggestions, and Dr. Marta Marthas from the California Regional Primate Research Center of the University of California at Davis for critical reading of the manuscript.
References
1. Anderson, M. G., D. Hauer, D. P. Sharma, S. V. Joag, O. Narayan, M. C. Zink, and J. E. Clements, 1993. Analysis of envelope changes acquired by SIVmac239 during neuroadaption in rhesus macaques. Virology 195,616Ð26.
2. Cohen, J., 1997. Weakened SIV vaccine still kills [news]. Science 278,24Ð5.
3. Conway, M. D., B. Davison-Fairburn, L. N. Martin, M. S. Insler, and M. Murphey-Corb, 1991. Infection of rhesus monkeys with topical instillation of simian immunodeficiency virus (SIV)B670 into the conjunctival sac. J Med Primatol 20,152Ð5.
4. Desrosiers, R. C., J. D. Lifson, J. S. Gibbs, S. C. Czajak, A. Y. Howe, L. O. Arthur, and R. P. Johnson, 1998. Identification of highly attenuated mutants of simian immunodeficiency virus. J Virol 72,1431Ð7.
5. Dewhurst, S., J. E. Embretson, D. C. Anderson, J. I. Mullins, and P. N. Fultz, 1990. Sequence analysis and acute pathogenicity of molecularly cloned SIVSMM- PBj14. Nature 345,636Ð40.
6. Dunn, C. S., B. Hurtrel, C. Beyer, L. Gloeckler, T. N. Ledger, C. Moog, M. P. Kieny, M. Mehtali, D. Schmitt, J. P. Gut, A. Kirn, and A. M. Aubertin, 1997. Protection of SIVmac-infected macaque monkeys against superinfection by a simian immunodeficiency virus expressing envelope glycoproteins of HIV type 1. AIDS Res Hum Retroviruses 13,913Ð22.
7. Heeney, J. L., 1996. Primate models for AIDS vaccine development. AIDS 10 Suppl A,S115-22.
8. Hirsch, V., D. Adger-Johnson, B. Campbell, S. Goldstein, C. Brown, W. R. Elkins, and D. C. Montefiori, 1997. A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3. J Virol 71,1608Ð20.
9. Joag, S. V., Z. Li, L. Foresman, E. B. Stephens, L. J. Zhao, I. Adany, D. M. Pinson, H. M. McClure, and O. Narayan, 1996. Chimeric simian/human immunodeficiency virus that causes progressive loss of CD4+ T cells and AIDS in pig-tailed macaques. J Virol 70,3189Ð97.
10. Johnson, R. P., and R. C. Desrosiers, 1998. Protective immunity induced by live attenuated simian immunodeficiency virus. Curr Opin Immunol 10,436Ð43.
11. Karlsson, G. B., M. Halloran, J. Li, I. W. Park, R. Gomila, K. A. Reimann, M. K. Axthelm, S. A. Iliff, N. L. Letvin, and J. Sodroski, 1997. Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys. J Virol 71,4218Ð25.
12. Kestler, H., T. Kodama, D. Ringler, M. Marthas, N. Pedersen, A. Lackner, D. Regier, P. Sehgal, M. Daniel, N. King, and et al., 1990. Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. Science 248,1109Ð12.
13. Kornfeld, H., N. Riedel, G. A. Viglianti, V. Hirsch, and J. I. Mullins, 1987. Cloning of HTLV-4 and its relation to simian and human immunodeficiency viruses. Nature 326,610Ð3.
14. Linhart, H., B. R. Gundlach, S. Sopper, U. Dittmer, K. Matz-Rensing, E. M. Kuhn, J. Muller, G. Hunsmann, C. Stahl-Hennig, and K. Uberla, 1997. Live attenuated SIV vaccines are not effective in a postexposure vaccination model. AIDS Res Hum Retroviruses 13,593Ð9.
15. Luciw, P. A., E. Pratt-Lowe, K. E. Shaw, J. A. Levy, and C. Cheng-Mayer, 1995. Persistent infection of rhesus macaques with T-cell-line-tropic and macrophage-tropic clones of simian/human immunodeficiency viruses (SHIV). Proc Natl Acad Sci U S A 92,7490Ð4.
16. Marthas, M. L., S. Sutjipto, J. Higgins, B. Lohman, J. Torten, P. A. Luciw, P. A. Marx, and N. C. Pedersen, 1990. Immunization with a live, attenuated simian immunodeficiency virus (SIV) prevents early disease but not infection in rhesus macaques challenged with pathogenic SIV. J Virol 64,3694Ð700.
17. Miller, C. J., M. B. McChesney, X. Lu, P. J. Dailey, C. Chutkowski, D. Lu, P. Brosio, B. Roberts, and Y. Lu, 1997. Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239. J Virol 71,1911Ð21.
18. Mori, K., D. J. Ringler, T. Kodama, and R. C. Desrosiers, 1992. Complex determinants of macrophage tropism in env of simian immunodeficiency virus. J Virol 66,2067Ð75.
19. Novembre, F. J., P. R. Johnson, M. G. Lewis, D. C. Anderson, S. Klumpp, H. M. McClure, and V. M. Hirsch, 1993. Multiple viral determinants contribute to pathogenicity of the acutely lethal simian immunodeficiency virus SIVsmmPBj variant. J Virol 67,2466Ð74.
20. Novembre, F. J., M. G. Lewis, M. M. Saucier, J. Yalley-Ogunro, T. Brennan, K. McKinnon, S. Bellah, and H. M. McClure, 1996. Deletion of the nef gene abrogates the ability of SIV smmPBj to induce acutely lethal disease in pigtail macaques. AIDS Res Hum Retroviruses 12,727Ð36.
21. Otsyula, M. G., C. J. Miller, A. F. Tarantal, M. L. Marthas, T. P. Greene, J. R. Collins, K. K. van Rompay, and M. B. McChesney, 1996. Fetal or neonatal infection with attenuated simian immunodeficiency virus results in protective immunity against oral challenge with pathogenic SIVmac251. Virology 222,27Ð58.
22. Putkonen, P., L. Walther, Y. J. Zhang, S. L. Li, C. Nilsson, J. Albert, P. Biberfeld, R. Thorstensson, and G. Biberfeld, 1995. Long-term protection against SIV-induced disease in macaques vaccinated with a live attenuated HIV-2 vaccine. Nat Med 1,914Ð8.
23. Quesada-Rolander, M., B. Makitalo, R. Thorstensson, Y. J. Zhang, E. Castanos-Velez, G. Biberfeld, and P. Putkonen, 1996. Protection against mucosal SIVsm challenge in macaques infected with a chimeric SIV that expresses HIV type 1 envelope. AIDS Res Hum Retroviruses 12,993Ð9.
24. Raghavan, R., E. B. Stephens, S. V. Joag, I. Adany, D. M. Pinson, Z. Li, F. Jia, M. Sahni, C. Wang, K. Leung, L. Foresman, and O. Narayan, 1997. Neuropathogenesis of chimeric simian/human immunodeficiency virus infection in pig-tailed and rhesus macaques. Brain Pathol 7,851Ð61.
25. Reimann, K. A., J. T. Li, R. Veazey, M. Halloran, I. W. Park, G. B. Karlsson, J. Sodroski, and N. L. Letvin, 1996. A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS- like disease after in vivo passage in rhesus monkeys. J Virol 70,6922Ð8.
26. Reimann, K. A., J. T. Li, G. Voss, C. Lekutis, K. Tenner-Racz, P. Racz, W. Lin, D. C. Montefiori, D. E. Lee-Parritz, Y. Lu, R. G. Collman, J. Sodroski, and N. L. Letvin, 1996. An env gene derived from a primary human immunodeficiency virus type 1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys. J Virol 70,3198Ð206.
27. Rud, E. W., J. R. Yon, B. A. Larder, B. E. Clarke, N. Cook, and M. Cranage. 1992. Infectious molecular clones of SIVmac32: Nef deletion controls ability to reisolate virus from rhesus macaques, p. 229Ð235. In F.Brown and R.M.Chanock and H.S.Ginsberg and R.A.Lerner (ed.), Vaccines. Cold Spring Harbor Laboratory Press, New York.
28. Ruprecht, R. M., T. W. Baba, V. Liska, R. Bronson, D. Penninck, and M. F. Greene, 1996. ÒAttenuatedÓ simian immunodeficiency virus in macaque neonates. AIDS Res Hum Retroviruses 12,459Ð60.
29. Schultz, A. M., and S. L. Hu, 1993. Primate models for HIV vaccines. AIDS 7 Suppl 1,S161Ð70.
30. Shibata, R., F. Maldarelli, C. Siemon, T. Matano, M. Parta, G. Miller, T. Fredrickson, and M. A. Martin, 1997. Infection and pathogenicity of chimeric simian-human immunodeficiency viruses in macaques: determinants of high virus loads and CD4 cell killing. J Infect Dis 176,362Ð73.
31. Stahl-Hennig, C., U. Dittmer, T. Nisslein, H. Petry, E. Jurkiewicz, D. Fuchs, H. Wachter, K. Matz-Rensing, E. M. Kuhn, F. J. Kaup, E. W. Rud, and G. Hunsmann, 1996. Rapid development of vaccine protection in macaques by live-attenuated simian immunodeficiency virus. J Gen Virol 77,2969Ð81.
32. Stephens, E. B., S. V. Joag, B. Atkinson, M. Sahni, Z. Li, L. Foresman, I. Adany, and O. Narayan, 1997. Infected macaques that controlled replication of SIVmac or nonpathogenic SHIV developed sterilizing resistance against pathogenic SHIV(KU-1).Virology 234,328Ð39.
33. Van Rompay, K. K., M. G. Otsyula, R. P. Tarara, D. R. Canfield, C. J. Berardi, M. B. McChesney, and M. L. Marthas, 1996. Vaccination of pregnant macaques protects newborns against mucosal simian immunodeficiency virus infection. J Infect Dis 173,1327Ð35.