Substances |
PDN
Description |
Status
(1) |
Acrolein |
- Exposure levels in humans living near hazardous waste
sites and other populations
- Exposure levels in children
- Dose-response data for chronic-duration (4)
via
inhalation exposure
|
Unfilled |
Aldrin/Dieldrin
|
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Arsenic |
- Comparative toxicokinetic studies to determine if an
appropriate animal species can be identified
- Half-lives in surface water, groundwater
|
Unfilled |
Asbestos |
- Epidemiologic studies of individuals occupationally
exposed to asbestos levels lower than those experienced
before the institution of current occupational standards
governing the use of asbestos, but higher than current
levels in the general population. These studies should be
performed in conjunction with the immunotoxicity studies
- Immunotoxicity studies of individuals occupationally
exposed to asbestos
- Development of human and rat lung retention models to
aid in extrapolating between rat and human data
- Exposure levels, fiber size distribution, and asbestos
fiber type in areas with natural geologic deposits of
friable asbestos and at hazardous waste sites. Also,
techniques for estimating air levels of asbestos from soil
concentrations and activity scenarios
- Exposure levels in humans living near hazardous waste
sites and in other populations, such as humans living in
areas with naturally high levels of friable asbestos
|
Unfilled |
Barium |
- Dose- response data for acute-duration(2) via oral
exposure
|
Unfilled
|
Benzene |
- Dose-response data in animals for acute- and
intermediate(3)-duration oral exposure. The
intermediate-duration study should include an extended
reproductive organ histopathology
- Prenatal developmental toxicity study via oral exposure
- Neurotoxicology battery of tests via oral exposure
|
Unfilled
|
Benzidine |
- Dose-response data for acute- and intermediate-duration
exposure via the oral route (the study of
intermediate-duration exposure should include evaluation of
reproductive and endocrine organ histopathology, lymphoid
tissues histopathology as well as examination of relevant
blood components, and nervous system histopathology)
- Exposure levels in humans living near hazardous waste
sites
- Exposure levels in children
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Beryllium |
- Dose-response data in animals for acute- and
intermediate-duration inhalation exposures. The
intermediate-duration study should include extended
reproductive organ histopathology
- Prenatal developmental toxicity study via inhalation
exposure
- Environmental fate in air; factors affecting
bioavailability in air
- Immunotoxicology battery of tests following oral
exposure
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Carbon tetrachloride |
- Dose-response data in animals for chronic oral
exposure. The study should include extended reproductive
organ and nervous tissue histopathology
- Potential candidate for subregistry of exposed
persons
|
Unfilled |
Chlordane
|
- Bioavailability studies following ingestion of
contaminated media
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Chlorinated dibenzo-p-dioxins (CDDs) |
- Studies via oral exposure designed to assess childhood
susceptibility
- Comparative toxicokinetic studies examining the relative
absorption of CDDs across exposure routes and the relative
contribution of each exposure route to total body burdens
|
Unfilled |
Chloroethane
|
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Chloroform
|
- otential candidate for subregistry of exposed persons
|
Unfilled |
Chromium |
- Dose-response data in animals for acute-duration
exposure to chromium (III) via oral exposure
- Multigeneration reproductive toxicity study via oral
exposure to chromium (III)
- Immunotoxicology battery of tests following oral
exposure to chromium (III) and (VI)
- Prenatal developmental toxicity study via oral exposure
to chromium (III)
|
Unfilled |
Cyanide |
- Potential candidate for subregistry of exposed persons
|
Unfilled |
1,2-dibromo-3-chloropropane
|
- Dose-response data in animals for acute-duration
exposure via the oral route (including reproductive organ
histopathology)
- Dose-response data in animals for chronic-duration
exposure via the oral route (including reproductive organ
histopathology)
- Prenatal developmental toxicity study via oral exposure
- Immunotoxicology testing battery via oral exposure
- Neurotoxicology testing battery via oral exposure
- Exposure levels in humans living near hazardous waste
sites and other exposed populations, such as exposed workers
- Potential candidate for subregistry of exposed persons
|
Unfilled |
1,2-Dibromoethane |
- Dose-response data in animals for acute- and
intermediate-duration exposure by the oral route (the study
of intermediate-duration exposure should include evaluation
of neuropathology and observation for overt signs of
neurotoxicity)
- Multigeneration reproductive toxicity studies via oral
exposure
- Prenatal toxicity studies via oral exposure
- Exposure levels in humans living near hazardous waste
sites and in other populations, such as workers exposed to
1,2-dibromoethane
- Exposure levels in children
- Potential candidate for subregistry of exposed persons
|
Unfilled |
1,2-Dichloroethane
|
- Dose-response data in animals for acute-duration
exposure by the inhalation route, including a comparison of
young and adult animals
- Dose-response data in animals for acute-duration
exposure by the oral route, including a comparison of young
and adult animals
- Dose-response data in animals for intermediate-duration
exposure by the inhalation route (the study should be
performed in conjunction with the neurotoxicology battery of
tests)
- Neurotoxicology battery of tests following oral exposure
- Dose-response data in animals for chronic-duration
exposure by the oral route
- Prenatal developmental toxicity data for inhalation
exposure (assessment of developmental cardiotoxicity and
neurotoxicity)
- Prenatal developmental toxicity data for oral exposure
(assessment of developmental cardiotoxicity and
neurotoxicity)
- Additional analyses and studies for comparative
toxicokinetics across species, ages, routes, and durations
- Children’s susceptibility
- Exposure levels in humans living near hazardous waste
sites
- Exposure levels in children
- Potential candidate for subregistry of exposed persons
|
Unfilled |
1,1-Dichloroethene |
- Carcinogenicity studies in two species following
inhalation exposure
- Reproductive toxicity studies assessing male and female
end points following inhalation exposure
- Immunotoxicology battery of tests following oral
exposure
- Battery of neurobehavioral tests following inhalation
exposure
- Children’s susceptibility
- Exposure levels in humans living near hazardous waste
sites
- Exposure levels in children
- Potential candidate for subregistry of exposed persons
|
Unfilled |
DDT |
- Dose-response data in animals for chronic-duration oral
exposure
- Comparative toxicokinetic study (across routes/species)
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Di(2-ethylhexyl) phthalate
|
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Di-n-butyl phthalate |
- Dose-response data in animals for chronic-duration
exposure via the oral route
- Carcinogenicity studies via oral exposure
- Bioavailability in contaminated environmental media near
hazardous waste sites
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Disulfoton |
- Exposure levels of disulfoton in tissues/fluids for
populations living near hazardous waste sites and other
populations, such as exposed workers
- Disulfoton should be considered as a potential candidate
for a subregistry of exposed persons
|
Unfilled |
Endosulfan (α,β, and sulfate) |
- Acute-duration oral exposure studies
- Data on sensitive neurologic end point following oral
exposure
- Exposure levels in humans living near hazardous waste
sites and other populations, such as exposed workers
- Data on the bioavailability of endosulfan from soil
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Endrin/endrin aldehyde |
- Dose-response animal data for acute oral exposure to
endrin
- Multigeneration reproductive toxicity studies via oral
exposure to endrin
- Accurately describe the toxicokinetics of endrin and its
degradation products and identify the animal species to be
used as the most appropriate model for human exposure
- Accurately describe the environmental fate of endrin,
including environmental breakdown products and rates, media
half-lives, and chemical and physical properties of the
breakdown products that help predict mobility and volatility
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Ethylbenzene |
- Dose-response data for acute-duration exposure by the
oral route
- Prenatal developmental study with continued assessment
of offspring during postnatal development following oral
exposure
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Heptachlor/
heptachlor epoxide
|
- Bioavailability from contaminated air, water, and soil
and bioaccumulation potential
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Hexachlorobutadiene |
- Dose-response data in animals for acute-duration
exposure via the oral route
- Exposure levels in humans living near hazardous waste
sites and other populations, such as exposed workers
- Environmental fate studies that determine the extent to
which hexachlorobutadiene volatilizes from soil, and studies
that determine the reactions and rates which drive
degradation in soil
- Bioavailability studies in soil and plants
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Hexachlorocyclohexane (α, β, γ, and δ)
|
- Mechanistic studies on the neurotoxicity, hepatotoxicity,
reproductive toxicity, and immunotoxicity of
Hexachlorocyclohexane
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Manganese
|
- Relative bioavailability of different manganese
compounds and bioavailability of manganese from soil
|
Unfilled |
Mercury
|
- Immunotoxicology battery of tests via oral exposure
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Methoxychlor
|
- Exposure levels of methoxychlor and primary metabolites
in humans living near hazardous waste sites and in those
individuals with the potential to ingest it
- Evaluate the fate, transport, and levels of the
degradation products of methoxychlor in soil
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Methylene chloride |
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Nickel
|
- Dose-response data in animals for acute- and
intermediate-duration oral exposures
- Neurotoxicology battery of tests via oral exposure
- Bioavailability of nickel from soil
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Pentachlorophenol
|
- Comparative toxicokinetic studies
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Polychlorinated biphenyls (PCBs)
|
- Dose-response data in animals for acute- and
intermediate-duration oral exposures
- Biodegradation of PCBs in water; bioavailability of PCBs
in air, water, and soil
- Dose-response data in animals for acute- and
intermediate-duration inhalation exposures. The
intermediate-duration study should include extended
reproductive organ histopathology
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Polycyclic aromatic hydrocarbons (PAHs)
(Includes 15 substances)
|
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Selenium
|
- Dose-response data in animals for acute-duration oral
exposure
- Immunotoxicology battery of tests via oral exposure
- Potential candidate for subregistry of exposed persons
|
Unfilled |
1,1,2,2-Tetrachloroethane
|
- Prenatal developmental toxicity study by the oral route
- Immunotoxicity battery following oral exposure
- Mammalian in vivo genotoxicity assays
- Exposure levels in humans living near hazardous waste
sites
- Exposure levels in children
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Tetrachloroethylene
|
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Toluene
|
- Potential candidate for subregistry of exposed persons
- Neurotoxicology battery of tests via oral exposure
|
Unfilled |
Toxaphene
|
- Identify the long-term health consequences of exposure
to environmental toxaphene via oral exposure
- Conduct additional immunotoxicity studies for
chronic-duration via oral route of exposure
- Conduct additional neurotoxicity studies for
chronic-duration via oral route of exposure
- Exposure levels in humans living in areas near hazardous
waste sites with toxaphene and in those individuals with the
potential to ingest it
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Vinyl chloride
|
- Dose-response data in animals for chronic-duration
inhalation exposure
- Mitigation of vinyl chloride-induced toxicity
- Exposure levels in humans living near hazardous waste
sites and other populations, such as exposed workers
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Xylenes |
- Neurotoxicology battery of tests following oral exposure
- Two-generation reproductive study following oral
exposure
- Exposure levels in humans living near hazardous waste
sites
- Potential candidate for subregistry of exposed persons
|
Unfilled |
Zinc
|
- Carcinogenicity testing (2-year bioassay) via oral
exposure
- Exposure levels in humans living near hazardous waste
sites and other populations, such as exposed workers
- Potential candidate for subregistry of exposed persons
|
Unfilled |