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BCL2 Gene

protein-coding GC18M058941

B-cell CLL/lymphoma 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

	Gene
Antibodies / RNAi / Pathways

	Antibodies / Pathways
	Proteins & Enzymes
	Assays/Kits / cDNA / RNAi

(According to ¹HGNC, ²Entrez Gene,
³UniProt/Swiss-Prot, ⁴UniProt/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl)
About This Section

Aliases
Bcl-2 ^{1, 2}
OTTHUMP00000163680 ²

Descriptions
B-cell CLL/lymphoma 2 ^{1, 2}
B-cell lymphoma protein 2 ²

External Ids
HGNC: 990¹
Entrez Gene: 596²
UniProt: P10415³
Ensembl: ENSG00000171791⁷

Search outside databases for aliases for BCL2 gene

Previous GC identifers: GC18M060629 GC18M060763 GC18M058939

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProt/Swiss-Prot, and/or UniProt/TrEMBL)
About This Section

EntrezGene summary for BCL2:

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death

of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of

translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma.

Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

UniProt/Swiss-Prot: BCL2_HUMAN, P10415

Function: Suppresses apoptosis in a variety of cell systems including factor-dependent

lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial

membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits

caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by

binding to the apoptosis-activating factor (APAF-1)

Gene Wiki entry for BCL2 (Bcl-2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views According to UCSC and Ensembl)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.33|18q21.3 Ensembl cytogenetic band: 18q21.33 HGNC cytogenetic band: 18q21.3

BCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M058941: (about GC identifiers)

Start:	58,941,559 bp from pter
End:	59,138,341 bp from pter
Size:	196,783 bases
Orientation:	minus strand

RefSeq genomic assemblies:

NC_000018.8 NT_025028.13

(According to ¹UniProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, BioMol, Abnova, and/or Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, and/or BioMol, Ontologies according to Gene Ontology Consortium 01 Jul 2008 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or GeneTex)
About This Section

UniProt/Swiss-Prot: BCL2_HUMAN, P10415 (See protein sequence)

Recommended Name: Apoptosis regulator Bcl-2

Size: 239 amino acids

Subunit: Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization

with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By

similarity). Also interacts with APAF1, RAF-1, TP53BP2, BBC3, BCL2L1, MRPL41 and BNIPL. Binding to

FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to

its targets

Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane;

Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein

PDB structures from and Proteopedia :

1G5M (3D)

1GJH (3D)

1YSW (3D)

2O21 (3D)

2O22 (3D)

2O2F (3D)

Secondary accessions: P10416 Q13842 Q16197

Alternative splicing: 2 isoforms: P10415-1 P10415-2

Post-translational modifications:

Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth

factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and

occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to

be phosphorylated by other protein kinases such as ERKs and stress-activated kinases.

Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity)¹

Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif,

has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further

caspase activity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000624.2 NP_000648.2

ENSEMBL proteins:

ENSP00000381185 ENSP00000329623

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	R&D Systems Recombinant & Natural Proteins for BCL2 (Bcl-2)
	Browse over 400 recombinant and purified proteins available from BIOMOL
	Recombinant Proteins from Abcam (Bcl2 alpha, Bcl2)
	Human Recombinant Proteins from Abnova (BCL2)

5/10 Gene Ontology (GO) cellular component terms (links to tree view) (see all 10):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	11530860
GO:0005739	mitochondrion	IDA	9027314
GO:0005741	mitochondrial outer membrane	TAS	1453000
GO:0005783	endoplasmic reticulum	IEA	--

About this table

Antibodies for BCL2:

	Invitrogen Antibodies for BCL2
	Millipore Mono- and Polyclonal Antibodies for the study of BCL2
	Sigma-Aldrich Antibodies for BCL2
	R&D Systems Antibodies for BCL2 (Bcl-2)
	Cell Signaling Technology (CST) Antibodies & Assays for BCL2 (Bcl-2)
	Antibodies from Abcam (Bcl2 alpha, Bcl2), each with their Abpromise^SM
	GeneTex Antibodies for BCL2 (10 antibodies available)
	Monoclonal and Polyclonal Antibodies from Abnova (BCL2)

Assays for BCL2:

	Invitrogen Assays for BCL2
	Millipore Kits and Assays for the Analysis of BCL2
	R&D Systems ELISA/Assay Development Kits & Reagents for BCL2 (Bcl-2) (see all)
	Browse biochemical assays available from BIOMOL

(According to InterPro, ProtoNet, UniProt, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P10415

ProtoNet protein and cluster: P10415

2 Blocks protein families:

IPB000712 Apoptosis regulator Bcl-2 protein

IPB003093 Apoptosis regulator Bcl-2 protein

UniProt/Swiss-Prot: BCL2_HUMAN, P10415

Domain: The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1

Similarity: Belongs to the Bcl-2 family

(According to MGI Aug 01 2008, UniProt, IUBMB,and/or Genatlas, RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, and/or Abnova, siRNAs from Applied Biosystems, Cell-based Assays from Millipore and DiscoveRx, Ontologies according to Gene Ontology Consortium 01 Jul 2008 via Entrez Gene.)
About This Section

RNAi:		Invitrogen RNAi Products for gene knock-down (BCL2)
		Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (BCL2)

Clones:		Invitrogen Clones for BCL2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

Primers:

Invitrogen Q-PCR LUX™ Primers for BCL2

siRNA:

Applied Biosystems Silencer® siRNAs for BCL2

UniProt/Swiss-Prot: BCL2_HUMAN, P10415

Function: Suppresses apoptosis in a variety of cell systems including factor-dependent

lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial

membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits

caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by

binding to the apoptosis-activating factor (APAF-1)

Genatlas biochemistry entry for BCL2:

inner mitochondrial membrane protein,C elegans CED9 homolog,key regulator of apoptosis by

inhibiting the release of cytochrome from the mitochondrial and by protecting a wide variety of

cells including B cells and neuronal cells,activated by nerve growth factor,mediated by the

p42/p44 MAPK cascade,inhibited by phosphorylation mediated by microtubule-damaging drugs through

JNK- and cAMP-dependent protein kinases ; interacting with SMN1,also modulating CDK2 activation

during thymocyte apoptosis,overexpressed in endometrial carcinoma

15/20 MGI mutant phenotypes (inferred from 5 alleles ) for Bcl2 (see all 20):

cardiovascular system	craniofacial	digestive/alimentary	endocrine/exocrine gland	growth/size
hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
life span-post-weaning/aging	muscle	nervous system	pigmentation	renal/urinary system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IDA	10620603
GO:0005515	protein binding	--	--
GO:0042803	protein homodimerization activity	IDA	9111042
GO:0046982	protein heterodimerization activity	IPI	9111042
GO:0051434	BH3 domain binding	IPI	9111042

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, KEGG and/or UniProt,
Pathway activation and profiling Assays by DiscoveRx, Sets of similar genes according to GeneDecks, Interactions according to ¹UniProt, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Jul 2008 via Entrez Gene.)
About This Section

5/36 Gene Ontology (GO) biological process terms (links to tree view) (see all 36):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0001836	release of cytochrome c from mitochondria	NAS	9027314
GO:0006915	apoptosis	--	--
GO:0006916	anti-apoptosis	IDA	9027314 10506221 10620603 11684014
GO:0006959	humoral immune response	TAS	1908951

About this table

5/29 Interacting proteins for BCL2 (P10415^{1, 2}) via UniProt, MINT, and/or STRING (see all 29)
Interactant Interaction Details
GeneCard External ID(s)
BCL2 P10415¹ EBI-77694, EBI-77694
FKBP8 Q14318² MINT-56638 MINT-56636 MINT-56637
MAPK14 Q16539² MINT-17661 MINT-17662 MINT-17663
PSEN1 P49768² MINT-16126 MINT-16125 MINT-16124
RTN4 Q9NQC3² MINT-15910 MINT-15911 MINT-15909
About this table

(Chemical Compounds according to BioMol, Tocris Bioscience, and/or AKS and Drugs according to BioMol and/or PharmGKB)
About This Section

Drugs & compounds for BCL2 protein from BIOMOL

Compounds and pharmacological data for BCL2 available from Tocris Bioscience

Compound	Action	CAS number
2,3-DCPE hydrochloride	Selectively induces cancer cell apoptosis	[418788-90-6]
Gossypol	Pro-apoptotic; downregulates Bcl-2 and Bcl-XL	[303-45-7]
HA14-1	Bcl-2 inhibitor. Induces apoptosis	[65673-63-4]

About this table

10/25 almaKnowledgeServer chemical compound relationships for BCL2 gene (see all 25)

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
genasense	81.84	42	16584297 (3), 16564596 (3), 11751483 (2), 12393493 (1) (see all 22)
dutp	75.29	32	9212738 (1), 11920781 (1), 12210368 (1), 14761612 (1) (see all 32)
noxa	72.07	36	17018621 (3), 16673057 (2), 16782027 (2), 17525724 (2) (see all 23)
oridonin	64.89	15	17260801 (3), 15008459 (2), 15703811 (2), 16638644 (1) (see all 10)
ptpc	63.35	7	11212328 (1), 10645010 (1), 10739647 (1), 12022943 (1) (see all 7)
ceramide	62.20	129	8643573 (5), 16297852 (5), 9841888 (5), 10400650 (5) (see all 60)
ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4h-chromene-3-carb oxylate	61.82	2	14966123 (1), 16510597 (1)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide	61.15	4	12144824 (1), 15033191 (1), 15749633 (1), 16243419 (1)
progesterone	58.47	285	17785366 (5), 8989276 (4), 9306964 (4), 8685038 (4) (see all 99)
sp 600125	58.45	7	16167336 (1), 16420771 (1), 16149076 (1), 15184882 (1) (see all 6)

About this table

2 PharmGKB drug compound relationships for BCL2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
cyclosporin a	FA	12086014
flavopiridol	FA	12170773

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 214 Homo sapiens; Jun 23 2008) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems,
Clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

RNAi:		Invitrogen RNAi Products for gene knock-down (BCL2)
		Millipore RNAi Products for the Analysis of BCL2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (BCL2)

REFSEQ mRNAs for BCL2 gene (2 alternative transcripts):

NM_000633.2 NM_000657.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000633 NM_000657

Applied Biosystems Silencer® siRNAs:

NM_000633 NM_000657

3 OriGene Full-length cDNA clones and unique splice variants in a CMV expression vector:

BC027258 NM_000633 NM_000657

Additional cDNA sequence:

AF401211.1 BC027258.1 EU287875.1 M13994.1 M13995.1 M14745.1 X06487.1

4 DOTS entries:

DT.216205 DT.100749960 DT.86998979 DT.40316825

24/148 AceView cDNA sequences (see all 148):

AI391699 W61100 AA321638 AW241434 N29770 F07940 AI142026 AI261915

BU195508 BM973833 BM986952 F04196 BG503428 N42615 BE550816 BQ440944

AI627828 BE503573 AU135900 AF401211 BM463468 BG388287 BQ215366 BM996398

highest scoring ESTs for BCL2:

AW364524 AW468867 BC027258 BE675587 BE832371 BE935192 BF516456 BQ054417 BQ055296 BQ055950

Unigene Cluster for BCL2:

B-cell CLL/lymphoma 2

Hs.150749 [show with all ESTs]

Unigene Representative Sequence: NM_000633

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for BCL2

ExUns:	1a	·	1b	^	2	^	3
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for BCL2

2 Ensembl transcripts including schematic representations:

ENST00000398117 ENST00000333681

(Experimental results according to ¹GeneNote and GNF SymAtlas,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 214 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProt,
Expression Assays from Applied Biosystems )
About This Section

BCL2 expression in normal and cancerous human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BCL2

Expression according to ¹ / ² / ³

13 probe-sets matching BCL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2060_at²^{, 3}	U95-A	1	1.00	1.00	0.40	0.89	M13995	0.60	1.00	0.82	1
1847_s_at²^{, 3}	U95-A	1	1.00	1.00	0.62	0.64	M13994	0.80	1.00	0.91	1
1910_s_at²^{, 3}	U95-A	1	1.00	1.00	0.28	1.11	M14745	0.60	1.00	0.82	1
1909_at²^{, 3}	U95-A	1	1.00	1.00	0.63	1.29	M14745	0.60	1.00	0.82	1
2038_g_at²^{, 3}	U95-A	1	1.00	1.00	0.58	1.11	M13995	0.60	1.00	0.82	1
203685_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000633	0.60	1.00	0.82	1
207005_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000657	0.60	1.00	0.82	1
207004_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000657	0.60	1.00	0.82	1
203684_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M13994	0.80	1.00	0.91	1
203685_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207005_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207004_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203684_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

the gene BCL2 for binary patterns associated with the probe-sets selected above.

About this table About GeneDecksing

Gene Expression data from

(See relevant publications) and GNF SymAtlas

About these images

About these images

CGAP SAGE TAG: TGTGTGGAGA
GNF BioGPS gene expression/activity chart for BCL2

SOURCE GeneReport for Unigene cluster: Hs.150749

Expression variation in blood from EXPOLDB for BCL2

UniProt/Swiss-Prot: BCL2_HUMAN, P10415

Tissue specificity: Expressed in a variety of tissues

(Orthologs according to ¹HomoloGene, ²euGenes, ³SGD and/or ⁴MGI Aug 01 2008, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BCL2 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BCL2¹	--	B-cell CLL/lymphoma 2	90.79(n) 89.54(a)	403416 NM_001002949.1 NP_001002949.1
chimpanzee (Pan troglodytes)	BCL2¹	--	B-cell CLL/lymphoma 2	100(n) 100(a)	738409 XM_001145537.1 XP_001145537.1
cow (Bos taurus)	BCL2¹	--	B-cell CLL/lymphoma 2	91.56(n) 94.76(a)	281020 XM_586976.3 XP_586976.3
rat (Rattus norvegicus)	Bcl2¹	--	B-cell leukemia/lymphoma 2	88.56(n) 89.41(a)	24224 NM_016993.1 NP_058689.1
mouse (Mus musculus)	Bcl2^{1, 4}	1 (59.80 cM)⁴	B-cell leukemia/lymphoma 2^{1, 4}	88.98(n)¹ 91.53(a)¹	12043¹ NM_009741.3¹ NP_033871.2¹ AA387478⁴ AA867214⁴ (see all 20)

About this table Species with no ortholog

ENSEMBL Gene Tree for BCL2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BCL2 gene

BCL2L7P1² BCL2A1² BCL2L2² MCL1² BCL2L1² BOK² BAX² BCL2L10²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProt, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/938 NCBI SNPs in BCL2 are shown (see all 938)
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 465)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1564483^1,2	A,C,F,H,O	58945634(-)	`GCCACA/GACCCT`	1	--	¹ ese³		19	MN EU EA WA NS NA	3048
--	rs2448799^1,2	A,C,F,H	58940466(-)	`GCTTGA/TAATTG`	1	--	¹		4	EU EA WA	372
	rs4987853^1,2	A,C,F,H	58944635(-)	`ATGGCA/GAATGA`	1	--	¹		26	NS EU EA WA NA	2654
	rs1016860^1,2	A,C,F,H	58946054(-)	`CTTAAA/GCCCTG`	1	--	¹		16	NA MN EU EA WA NS	1658
	rs1893806^1,2	A,C,F,H	59135944(-)	`AGCTTG/TTTGGA`	2	--	¹ int¹		16	EA NA MN EU WA NS	1594
	rs4987861^1,2	C,F,H	58943544(-)	`GAAAAC/TTCTGG`	1	--	¹ ese³		14	NS EU EA WA NA	1394
	rs4987852^1,2	C,F,H	58944901(-)	`TTCTGA/GGAAGG`	1	--	¹ ese³		16	NS EU EA WA NA	1560
	rs1473418^1,2	C,F,H	59137529(-)	`TCCCCC/GCGACT`	2	--	¹ ese³		9	NA EA MN EU WA NS	1026
	rs4987855^1,2	C,F,H	58944529(-)	`TCCGCG/AGGGGC`	1	--	¹ ese³		12	NS EU EA WA NA	1120
--	rs4987872^1,2	C,F,H	58940978(-)	`CATACT/CACCTT`	1	--	¹		9	NS EU EA WA	978

About this table

HapMap Linkage Disequilibrium images for BCL2

(in which this Gene is Involved, According to OMIM, UniProt, AKS, PharmGKB, Genatlas, GeneTests, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 151430
search databases for these OMIM-named disorders:

Leukemia/lymphoma, B-cell, 2

UniProt/Swiss-Prot: BCL2_HUMAN, P10415

A chromosomal aberration involving BCL2 may be a cause of follicular lymphoma (FL)

[MIM:151430]; also known as type II chronic lymphatic leukemia. Translocation t(14;18)(q32;q21)

with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the

chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting

in nucleotide transitions

10/92 almaKnowledgeServer disease relationships for BCL2 gene (see all 92)

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma follicular	88.00	317	2223650 (5), 9349233 (4), 8623759 (4), 8252486 (4) (see all 99)
tumors	82.79	2688	2214188 (7), 9002964 (7), 17295204 (6), 15667975 (6) (see all 99)
lymphoma b-cell	81.54	228	8639245 (3), 8106752 (3), 1951637 (3), 17404107 (3) (see all 99)
lymphoma	78.06	533	16373664 (5), 1890741 (5), 11431360 (5), 9758366 (5) (see all 99)
cancer	75.37	598	9416483 (5), 11728179 (5), 9000560 (4), 16531274 (4) (see all 99)
leukemia	71.68	257	18422996 (5), 10456672 (4), 10023011 (4), 14689061 (3) (see all 99)
lymphoma non-hodgkins	69.18	144	15503680 (3), 11380403 (3), 9113013 (3), 1747446 (2) (see all 99)
breast cancer	68.68	573	11235572 (5), 17626754 (5), 17288732 (5), 17352236 (4) (see all 99)
lymphocytic leukemia chronic b-cell	68.46	29	8104532 (2), 9373241 (1), 17132110 (1), 8260892 (1) (see all 26)
necrosis	68.31	198	10064615 (4), 10464427 (3), 10754212 (2), 14646554 (2) (see all 99)

About this table

Genatlas disease: BCL2

non Hodgkin follicular lymphoma of B-cell type,diffuse large B cell lymphoma,with translocation

t(14;18)(q32;q21.3),also extranodal B cell lymphoma (low grade lymphoma of mucosa associated

lymphoid tissue),with translocation t(11;18)(q21;q21) and a breakpoint on chromosome 18 between

BCL2 and DCC

Human Gene Mutation Database: BCL2

Genetic Association Database: BCL2

Human Genome Epidemiology Navigator: BCL2 (20 documents)

Tumor Gene Database: BCL2

Breast Cancer Gene Database: BCL2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹AKS, ²HGNC, ³Entrez Gene, ⁴UniProt/Swiss-Prot, ⁵UniProt/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/677 PubMed articles for BCL2 gene (see all 677):

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. (PubMed id 17200714)^{1, 3} Del Gaizo Moore V....Letai A. (2007)
Prognostic relevance of a novel semiquantitative classification of Bcl2 immunohistochemical expression in human infiltrating ductal carcinomas of the breast. (PubMed id 17372162)^{1, 3} Trere D....Derenzini M. (2007)
BCL-2 functions as an activator of the AKT signaling pathway in pancreatic cancer. (PubMed id 17960583)^{1, 3} Mortenson M.M....Bold R.J. (2007)
Effect of osteoblast-targeted expression of bcl-2 in bone: differential response in male and female mice. (PubMed id 16007339)^{1, 3} Pantschenko A.G....Gronowicz G.A. (2005)
The value of serum Bcl-2 levels in advanced lung cancer patients. (PubMed id 15965276)^{1, 3} Tas F....Topuz E. (2005)
Expression of bcl-2 in papillary thyroid cancers and its prognostic value. (PubMed id 16438077)^{1, 3} Aksoy M....Tezelman S. (2005)
Association between glutathione S-transferase genotypes and Hodgkin's lymphoma risk and prognosis. (PubMed id 12960134)^{3, 6} Hohaus S....Leone G. (2003)
Sequence-based polymorphisms in members of the apoptosis Bcl-2 gene family and their association with hematocrit level. (PubMed id 14714449)^{3, 6} Zeng S.M....Strauss R.G. (2003)
Investigation of bax, bcl-2, bcl-x and p53 gene polymorphisms in multiple sclerosis. (PubMed id 12161031)^{3, 6} Kuhlmann T....Bruck W. (2002)
[Association between Bcl-2 gene polymorphism with systemic lupus erythematosus] (PubMed id 12133517)^{3, 6} Wu H....Chen S. (2002)

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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 596	HGNC: 990	AceView: BCL2	Ensembl:ENSG00000171791	euGenes: HUgn596
ECgene: BCL2	H-InvDB: BCL2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProt/Swiss-Prot, and/or UniProt/TrEMBL,
Wikipedia and/or GeneReviews via UniProt/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for BCL2	Genetics and Cytogenetics in Oncology and Haematology
	http://en.wikipedia.org/wiki/Bcl-2

BCL2 Licensable Technologies
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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, GeneTex,
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Products for BCL2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

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Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
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Millipore Preclinical / Clinical Development Services

Millipore Immunoassay Services

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Antibodies & Assays for BCL2 (Bcl-2)

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	Antibodies (Bcl2 alpha, Bcl2)

Full-length cDNA clones and shRNA constructs in expression vectors

Tocris compounds for BCL2

	Drugs for BCL2
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Search GeneTex for antibodies for BCL2

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GeneCards Homepage - Last full update: 22 Aug 2008 Incremental updates: 1 Sep 2008 , 4 Sep 2008 , 7 Sep 2008 , 8 Sep 2008

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BCL2 Gene

protein-coding GC18M058941

BCL2
Aliases &
Descriptions

BCL2
Summaries

BCL2
Genomic
Location

BCL2
Proteins

BCL2
Protein Domains/
Families

BCL2
Gene Function

BCL2
Pathways & Interactions

BCL2
Drugs & Compounds

BCL2
Transcripts

BCL2
Expression
in Human Tissues

BCL2
Similar Genes in Other Organisms

BCL2
Paralogs

BCL2
SNPs/Variants

BCL2
Disorders & Mutations

BCL2
Medical News

BCL2
Research Articles

Search for BCL2

BCL2 in Other Human Genome Wide Resources

BCL2 in General Databases, Limited Scope

BCL2 in Specialized Databases

BCL2
Licensable Technologies

BCL2
Services

BCL2 Gene

protein-coding GC18M058941

BCL2Aliases & Descriptions

BCL2Summaries

BCL2GenomicLocation

BCL2Proteins

BCL2Protein Domains/Families

BCL2Gene Function

BCL2Pathways & Interactions

BCL2Drugs & Compounds

BCL2Transcripts

BCL2Expression in Human Tissues

BCL2Similar Genes in Other Organisms

BCL2Paralogs

BCL2SNPs/Variants

BCL2Disorders & Mutations

BCL2Medical News

BCL2Research Articles

Search for BCL2

BCL2 in Other Human Genome Wide Resources

BCL2 in General Databases, Limited Scope

BCL2 in Specialized Databases

BCL2Licensable Technologies

BCL2Services

BCL2
Aliases &
Descriptions

BCL2
Summaries

BCL2
Genomic
Location

BCL2
Proteins

BCL2
Protein Domains/
Families

BCL2
Gene Function

BCL2
Pathways & Interactions

BCL2
Drugs & Compounds

BCL2
Transcripts

BCL2
Expression
in Human Tissues

BCL2
Similar Genes in Other Organisms

BCL2
Paralogs

BCL2
SNPs/Variants

BCL2
Disorders & Mutations

BCL2
Medical News

BCL2
Research Articles

BCL2
Licensable Technologies

BCL2
Services