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Research Funded by NIEHS - Extramural Research Programs Comparative Biology Grantees Brown University Children's Hospital of Philadelphia Dana-Farber Cancer Institute Duke University Mount Desert Island Biological Laboratory University of California Los Angeles University of Massachusetts Amherst University of Pennsylvania University of Texas Health Science Center San Antonio University of Texas MD Anderson Cancer Center - John DiGiovanni University of Texas MD Anderson Cancer Center - Karen Vasquez University of Texas Southwestern Medical Center Dallas All Scientists All Laboratories	University of Texas Southwestern Medical Center Dallas Universal Determinants of Alcohol-Induced Toxicity John Abrams, Ph.D. john.abrams@southwestern.edu Project Description This grant is focused on studying pathways relevant to alcohol-induced toxicity which is a risk factor relevant to birth defects, cancer, cirrhosis and many other human diseases. The central hypothesis predicts that core effectors of alcohol toxicity are universally shared across the animal kingdom and likely define authentic targets for therapeutic intervention. Conserved pathways relevant to ethanol-induced toxicity and corresponding apoptosis will be compared in human, Zebrafish, and Drosophila systems. This grant is of interest to both the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and NIEHS and will be funded by both institutes.
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This page URL: http://www.niehs.nih.gov/research/supported/programs/compbio/grantees/utsmcd.cfm NIEHS website: http://www.niehs.nih.gov/ Email the Web Manager at webmanager@niehs.nih.gov Last Reviewed: August 12, 2008