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Comparative Mechanisms of Genomic InstabilityKaren M. Vasquez, Ph.D. Project DescriptionThis grant funds the study of the mechanisms relevant to the breakages on translocated genes which are implicated in multiple cancers. This application attempts to address why double-strand breaks tend to occur in certain genomic fragile "hotspots" and the effects of several environmental agents on the genomic instability at these susceptible locations in yeast, mice and humans. Specifically, non-B DNA-induced genetic instability will be measured in different species and the susceptibility of non-B DNA sequences to environmental carcinogen-induced DNA damage and mutagenesis will be determined. |
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