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Genetics and Pathobiology of Vascular Cognitive Impairment (R21)
Release Date: March 24, 2006
Announcement Number: PAS-06-265
Application Receipt Date:
June 1, 2006
October 1, 2006
February 16, 2007
June 16, 2007
Funding Contact: NINDS Funding
Program Area: Neurogenetics
Brief Description:
The purpose of this funding opportunity announcement (FOA) with set-aside funds is to invite applications to study the biological
basis of vascular cognitive impairment (VCI). VCI causes a burden of illness similar to that caused by Alzheimer’s disease
(AD), but has been far less well-studied. Recently, however, some important strides have been made in understanding the etiology
of VCI. These include the discovery of a monogenic form of vascular dementia, CADASIL, and identification of the causative
gene as Notch 3. In addition, MRI and other pathological data have provided a clearer delineation of the various clinical
subtypes of VCI, and awareness of the synergistic interaction between vascular and classical Alzheimer’s pathologies in producing
cognitive impairment. The goal of this FOA is to build on these first critical achievements to obtain a better understanding
of the cellular and molecular mechanisms causing vascular, neural, and glial dysfunction in human VCI and animal models of
VCI.
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