Our Science – Phang Website
James M. Phang, M.D.
Selected Publications |
1)
Surazynski A, Miltyk W, Palka J, Phang JM. Prolidase-dependent regulation of collagen biosynthesis. Amino Acids. 2008. [Journal] |
2)
Phang JM, Donald SP, Pandhare J, Liu Y. The metabolism of proline, a stress substrate, modulates carcinogenic pathways. Amino Acids. 2008. [Journal] |
3)
Cooper SK, Pandhare J, Donald SP, Phang JM. A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species. J. Biol. Chem. 283: 10485-92, 2008. [Journal] |
4)
Phang JM, Pandhare J, Liu Y. The metabolism of proline as microenvironmental stress substrate. J. Nutr. 138: 2008S-15S, 2008. [Journal] |
5)
Phang JM. Introduction to second proline symposium. Amino Acids. 2008. [Journal] |
6)
Liu Y, Borchert GL, Surazynski A, Phang JM. Proline oxidase, a p53-induced gene, targets COX-2/PGE(2) signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. Oncogene. 2008. [Journal] |
7)
Phang JM, Pandhare J, Zabirnyk O, Liu Y. PPARgamma and Proline Oxidase in Cancer. PPAR research. 2008: 542694, 2008. [Journal] |
8)
Hu CA, Phang JM, Valle D. Proline metabolism in health and disease. Amino Acids. 2008. [Journal] |
9)
Surazynski A, Donald SP, Cooper SK, Whiteside MA, Salnikow K, Liu Y, Phang JM. Extracellular matrix and HIF-1 signaling: the role of prolidase. Int. J. Cancer. 122: 1435-40, 2008. [Journal] |
10)
Hu CA, Donald SP, Yu J, Lin WW, Liu Z, Steel G, Obie C, Valle D, Phang JM. Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis. Mol. Cell. Biochem. 295: 85-92, 2007. [Journal] |
11)
Liu Y, Borchert GL, Surazynski A, Hu C, Phang JM. Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling. Oncogene, EPub April 17. 25: 5640-5647, 2006. [Journal] |
12)
Pandhare J, Cooper SK, Phang JM. Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms. J Biol Chem. 281: 2044-52, 2006. [Journal] |
13)
Surazynski A, Liu Y, Miltyk W, Phang JM. Nitric oxide regulates prolidase activity by serine/threonine phosphorylation. J Cell Biochem. 96: 1086-1094, 2005. [Journal] |
14)
Dabrowski K, Terjesen BF, Zhang Y, Phang JM, Lee KJ. A concept of dietary dipeptides: a step to resolve the problem of amino acid availability in the early life of vertebrates. J Exp Biol. 208: 2885-94, 2005. [Journal] |
15)
Liu Y, Borchert GL, Donald SP, Surazynski A, Hu CA, Weydert CJ, Oberley LW, Phang JM. MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells. Carcinogenesis. 26: 1335-42, 2005. [Journal] |
16)
Miltyk W, Surazynski A, Kasprzak KS, Fivash MJ, Buzard GS, Phang JM. Inhibition of prolidase activity by nickel causes decreased growth of proline auxotrophic CHO cells. J Cell Biochem. 94: 1210-7, 2005. [Journal] |
17)
Hursting SD, Lavigne JA, Berrigan D, Donehower LA, Davis BJ, Phang JM, Barrett JC, Perkins SN. Diet-gene interactions in p53-deficient mice: Insulin-like growth factor-1 as a mechanistic target. J Nutr. 134: 2482S-2486S, 2004. [Journal] |
18)
Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS. Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J Biol Chem. 24: 40337-44, 2004. [Journal] |
19)
Liu Y, Borchert GL, Phang JM. Polyoma enhancer activator 3, an Ets transcriptional factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells. J Biol Chem. 279: 18694-700, 2004. [Journal] |
20)
Phang JM. Goldman L, Ausiello D, eds. The hyperprolinemias and hydroxyprolinemia. In: Cecil Textbook of Medicine. Volume 22nd edition. Philadelphia: Saunders; 2004. p. 1285 [Book Chapter] |
21)
Mei JM, Borchert GL, Donald SP, Phang JM. Matrix metalloproteinase(s) mediate(s) NO-induced dissociation of beta-catenin from membrane bound E-cadherin and formation of nuclear beta-catenin/LEF-1 complex. Carcinognesis. 23: 2119-2122, 2002. [Journal] |
22)
Peng Y, Xu RH, Mei JM, Li XP, Yan D, Kung HF, Phang JM. Neural inhibition by c-Jun as a synergizing factor in bone morphogenetic protein 4 signaling. Neuroscience. 109: 657-64, 2002. [Journal] |
23)
Hursting SD, Shen JC, Sun XY, Wang TT, Phang JM, Perkins SN. Modulation of cyclophilin gene expression by N-4-(hydroxyphenyl)retinamide: association with reactive oxygen species generation and apoptosis. Mol Carcinog. 33: 16-24, 2002. [Journal] |
24)
Donald SP, Sun XY, Hu CA, Yu J, Mei JM, Valle D, Phang JM. Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species. Cancer Res. 61: 1810–5, 2001. [Journal] |
25)
Sun XY, Donald SP, Phang JM. Testosterone and prostate specific antigen stimulate generation of reactive. Carcinogenesis. 22: 1775-80, 2001. [Journal] |
26)
Phang JM. Creighton T, eds. Prolidase. In: Encyclopedia of Molecular Medicine. Volume . New York: John Wiley & Sons; 2001. p. 2585-9 [Book Chapter] |
27)
Phang JM, Hu CA, Valle D. Scriver CR, Beaudet AL, Sly WS, Valle D, eds. Disorders of proline and hydroxyproline metabolism. In: Metabolic and Molecular Basis of Inherited Disease. Volume 8th edition. New York: McGraw-Hill; 2001. p. 1821-38 [Book Chapter] |
28)
Mei JM, Hord NG, Winterstein DF, Donald SP, Phang JM. Expression of prostaglandin endoperoxide H synthase-2 induced by nitric oxide in. FASEB J. 14: 1188-201, 2000. [Journal] |
29)
Hursting SD, Perkins SN, Phang JM, Barrett JC. Diet and cancer prevention studies in p53-deficient mice. J. Nutr. 131: 3092S-4S, 2001. [Journal] |
30)
Mei JM, Hord NG, Winterstein DF, Donald SP, Phang JM. Differential formation of beta-catenin/lymphoid enhancer factor-1 DNA binding complex induced by nitric oxide in mouse colonic epithelial cells differing in adenomatous polyposis coli (Apc) genotype. Cancer Res. 60: 3379-83, 2000. [Journal] |
31)
Mei JM, Hord NG, Winterstein DF, Donald SP, Phang JM. Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated beta-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in Apc. Carcinogenesis. 20: 737-40, 1999. [Journal] |
32)
Hursting SD, Slaga TJ, Fischer SM, DiGiovanni J, Phang JM. Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice. J. Natl. Cancer Inst. 91: 215-25, 1999. [Journal] |
This page was last updated on 9/24/2008.