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Medicine in the post-genomic era
Current Issue
The complete issue of Genome Medicine Volume 1 Issue 4 is now available in full online
Table of contents
Aims & scope
Genome Medicine is an online peer-reviewed journal which publishes open access research articles of outstanding quality in all areas of medicine studied from a genomic or post-genomic perspective. The journal has a special focus on the latest technologies and findings that have an impact on the understanding and management of human health and disease.
Musings on genome medicine
Each issue of Genome Medicine features a regular column by David G Nathan and Stuart Orkin tackling a variety of controversial topics and providing a unique, exciting perspective on the events and developments in genomic medicine.
Latest review
All reviews, commentaries and reports published in Genome Medicine are free to read. See below for the latest free review.
Quotes
“High-throughput experimental and computational technologies are revolutionizing our understanding of life by enabling global systems approaches beyond classical analytical molecular and cellular biology.
Genome Medicine is a timely initiative to foster this transition from the highly fragmented scientific and medical landscape to the integrative systems biology and medicine which are needed to translate fundamental discoveries into useful healthcare services for the benefit of individual patients worldwide.
Professor Charles Auffray,
Genome Medicine Section Editor
LGN CNRS/Université Pierre et Marie Curie, France.
Featured articles
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Genome Medicine
2009,
1:47
The first large-scale proteomic analysis of samples from the Women's Health Initiative reveals that estrogen replacement therapy affects at least 10% of the serum proteome, particularly proteins involved in processes related to cardiovascular disease and osteoporosis.
-
Genome Medicine
2009,
1:46
The integration of genome-wide association studies within the design of pharmacogenomics trials is currently underexploited but holds promise for accelerating the transfer of gene discoveries into clinical practice.
-
Genome Medicine
2009,
1:42
James R Lupski reviews the last decade of research into genomic disorders, from the original discoveries to their current position as one of the hottest fields of the post-genomic era.
-
Genome Medicine
2009,
1:39
A kernel-based supervised classification algorithm allows the integration of genome-wide data from different sources and improves the prediction of clinical outcomes from cancer data sets.
Latest articles 
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Genome Medicine
2009,
1:48
(8 May 2009)
Integration of a dynamic uniform electronic health record is essential for the success of patient counseling on the basis of genome-wide data.
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Genome Medicine
2009,
1:49
(6 May 2009)
Our understanding of the genetics and cell biology of cancer continues to grow, and with this understanding will come the drugs that will help to make cancer a manageable, if not a curable, disease.
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Research
Application of serum proteomics to the Women's Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings
Hiroyuki
Katayama,
Sophie
Paczesny,
Ross
Prentice,
Aaron
Aragaki,
Vitor
M
Faca,
Sharon
J
Pitteri,
Qing
Zhang,
Hong
Wang,
Melissa
Silva,
Jacob
Kennedy,
Jacques
Rossouw,
Rebecca
Jackson,
Judith
Hsia,
Rowan
Chlebowski,
JoAnn
Manson,
Samir
Hanash
Genome Medicine
2009,
1:47
(29 April 2009)
The first large-scale proteomic analysis of samples from the Women's Health Initiative reveals that estrogen replacement therapy affects at least 10% of the serum proteome, particularly proteins involved in processes related to cardiovascular disease and osteoporosis.
-
Genome Medicine
2009,
1:46
(28 April 2009)
The integration of genome-wide association studies within the design of pharmacogenomics trials is currently underexploited but holds promise for accelerating the transfer of gene discoveries into clinical practice.
-
Genome Medicine
2009,
1:45
(28 April 2009)
A brief report on the Perspectives in Stem Cell Proteomics Conference, Hinxton, UK, 22-23 March, 2009.
-
Genome Medicine
2009,
1:44
(28 April 2009)
The sequencing of the genomes of all human rhinovirus (HRV) serotypes opens the road to comprehensive HRV characterization and offers valuable information for phylogenetic analysis and the development of novel therapeutics.
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Genome Medicine
2009,
1:43
(28 April 2009)
Genome-wide scans have revealed novel susceptibility loci for essential hypertension and are being used to look for alleles that predict individual response to antihypertensive drugs, opening the way for personalized therapy for hypertensive patients.
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Genome Medicine
2009,
1:42
(24 April 2009)
James R Lupski reviews the last decade of research into genomic disorders, from the original discoveries to their current position as one of the hottest fields of the post-genomic era.
-
Genome Medicine
2009,
1:41
(22 April 2009)
A report on the Genomic Disorders conference on Genomic Variation in Health and Disease, Hinxton, UK, 9–11 March, 2009.
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Genome Medicine
2009,
1:40
(17 April 2009)
The impact of next-generation sequencing on medical research is dramatically increasing, although there are challenges that must be overcome to fully translate this technology into routine clinical practice.
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Genome Medicine
2009,
1:39
(3 April 2009)
A kernel-based supervised classification algorithm allows the integration of genome-wide data from different sources and improves the prediction of clinical outcomes from cancer data sets.
-
Genome Medicine
2009,
1:38
(3 April 2009)
Despite slow progress and many barriers, the gene therapy may now be poised to move forward rapidly though the promises of site-specific gene correction using modified nucleases and the conversion of corrected somatic cells to functioning hematopoietic stem cells.
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Genome Medicine
2009,
1:37
(2 April 2009)
If genetic risk information is to have any benefit on health, it needs to prompt individuals to pursue risk-reduction behaviors, yet early evidence suggests that genetic risk may not be an effective motivator of behavior change.
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Genome Medicine
2009,
1:36
(2 April 2009)
MACC1, a newly discovered gene that regulates the hepatocyte growth factor/receptor signaling cascade, may prove valuable for determining risk for colorectal cancer and as a target for its treatment.
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Genome Medicine
2009,
1:35
(30 March 2009)
While the challenges of integrating very different types of data and perspectives of disease into a global model suitable for dissecting disease mechanisms and predicting therapeutic strategies are great, models based upon multiple datasets will become the basis that drives future research.
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