Alan P.
Koretsky Ph.D., Senior InvestigatorDr. Koretsky received his S.B. degree from the Massachusetts Institute of
Technology and Ph.D. from the University of California at Berkeley. He
performed postdoctoral work in the NHLBI at NIH studying regulation of
mitochondrial metabolism using optical and NMR techniques. Dr. Koretsky spent
twelve years on the faculty in the Department of Biological Sciences at Carnegie
Mellon University where he was the Eberly Professor of Structural Biology and
Chemistry. In summer 1999, he moved to NINDS as Chief of the Laboratory of
Functional and Molecular Imaging and Director of the NIH MRI Research Facility.
Dr. Koretsky's laboratory is interested in two main areas. They are actively
developing novel imaging techniques to visualize brain function and study the
regulation of cellular energy metabolism combining molecular genetics with
non-invasive imaging tools.
Laboratory StaffKevin Bennett, Ph.D., IRTA Fellow
, 301-402-
9709
Kai-Hsiang Chuang, Ph.D., Postdoctoral Fellow
, 301-594-
7314
Richard Conroy, Ph.D., Guest Researcher
, 301-594-
7310
Steve Dodd, Ph.D., Research Fellow
, 301-402-
0389
Artem Goloshevsky, Ph.D., Research Fellow
, 301-435-
2146
Tom Hu, Ph.D., Special Volunteer
, 301-402-
1329
Mary Kiganda, M.S., Biologist
, 301-435-
7945
Galit Pelled, Ph.D., IRTA Fellow
, 301-451-
9936
Erik Shapiro, Ph.D., Special Volunteer
, 301-594-
7311
Kathy Sharer, , Research Assistant
, 301-402-
9652
James Sumner, Ph.D., IRTA Fellow
, 301-594-
0365
Jason Tucciarone, B.S., Post baccalaureate Fellow
, 301-435-
2148
Carolyn Wu, Ph.D., Research Fellow
, 301-451-
9913
Research InterestsThe Functional and Molecular Imaging Section has two major research interests. One is to develop novel functional and molecular
imaging techniques to study brain structure and function. Emphasis is on MRI but some optical imaging is performed as well.
Current areas of interest are to extend spatial resolution and understand the relation of functional MRI to neuronal architecture.
New imaging tools are being developed to image calcium influx and gene expression non-invasively in the mouse brain.
Selected Recent PublicationsK. Chuang, A.P. KoretskyImproved Neuronal Tract Tracing Using Manganese Enhanced Magnetic Resonance Imaging with Fast T1 Mapping - Magnetic Resonance in Medicine
55 604-611 2006
S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, A.P. KoretskyBOLD and CBV-Weighted Functional Magnetic Resonance Imaging of the Rat Somatosensory System - Magnetic Resonance in Medicine
55 316-324 2006
I. Aoki, Y. Takahashi, K. Chuang, A.C. Silva, T. Igarashi, C. Tanaka, R.W. Childs, A.P. KoretskyCell Labeling for Magnetic Resonance Imaging with the T1 Agent Manganese Chloride - NMR in Biomedicine
19 50-59 2006
O. Rodriguez, S. Fricke, C. Chien, L. Dettin, J. Vanmeter, E.M. Shapiro, H. Dai, M. Casimiro, L. Lleva, J. Dagata, M.D. Johnson,
M.P. Lisanti, A.P. Koretsky, C. AlbaneseContrast-Enhanced in Vivo Imaging of Breast and Prostate Cancer Cells by MRI - Cell Cycle
5 113-119 2006
E.M. Shapiro, K. Sharer, Skrtic, A.P. KoretskyIn Vivo Detection of Single Cells By MRI - Magnetic Resonance in Medicine
55 242-249 2006
J.H. Duyn, P. van Gelderen, S.L. Talagala, A.P. Koretsky, J.A. de ZwartTechnological Advances in MRI Measurement of Brain Perfusion - Journal of Magnetic Resonance Imaging
22 751-753 2005
Selected Earlier Publications
Contact InformationLaboratory of Functional and Molecular Imaging, NINDS Building 10, Room B1D728
10 Center Drive, MSC 1065
Bethesda MD
20892-1065
Telephone:
301-402-
9659 (office), 301-
402-9659 (laboratory),
301-480-
2558 (fax), Email:
koretskya@ninds.nih.gov