CANINE OLIGONUCLEOTIDE MICROARRAY

One of the goals of the Comparative Oncology Program (COP) is to characterize and validate the use of companion animals as models for human disease. One approach used towards validation will be through genomic and proteomic analysis. This will allow gene and protein expression profiles of canine tissues and diseases as a platform to be compared to human tissues.

The Affymetrix Canine Genome 2.0 Array provides a platform to conduct this genomic analysis.

It is our goal to initially characterize 10 normal canine organs using expression analysis, and make this expression database publicly available. These 10 tissues include: liver, renal cortex, renal medulla, heart, cerebrum, bone marrow, lymph node, jejunum, skeletal muscle, and lung.

The database will be coming soon.

For more information regarding the Comparative Oncology Program’s microarray work, please contact Melissa Paoloni at paolonim@mail.nih.gov