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COTC Pharmacodynamic (PD) Core
As an extension of the efforts of the Comparative Oncology Program's
in house "tool kit" the Comparative Oncology Trials Consortium
Pharmacodynamic (COTC PD) Core was developed. This multidisciplinary
effort operates as a laboratory with "virtual walls" consisting of
services provided by investigators who have competed for the opportunity
to contribute to the assay/procedure service catalog of the Core.
The service catalog includes a list of assays, associated costs,
and validation (for canine tissues) of each service item. The COTC
PD CORE is meant to facilitate early discussions with COTC trial
sponsors (pharmaceutical companies) by providing the infrastructure
for rapid implementation of preclinical studies needed to initiate
a COTC study and then seamlessly support the clinical pharmacodynamic
and biological endpoints of COTC trials. Services provided by the COTC
PD Core include:
- pathology
- immunohistochemistry
- immmunocytochemistry
- flow cytometry
- genomics
- proteomics
- pharmacokinetics
- cell biology
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