Skip CCR Main Navigation National Cancer Institute National Cancer Institute U.S. National Institutes of Health www.cancer.gov
CCR - For Our Staff| Home |

Our Science – Lubkowski Website

Jacek Tadeusz Lubkowski, Ph.D.

Selected Publications
1)  Zou G, de Leeuw E, Lubkowski J, Lu W.
Molecular Determinants for the Interaction of Human Neutrophil alpha Defensin 1 with its Propeptide.
J. Mol. Biol. 2008. [Journal]
2)  Barinka C, Hlouchova K, Rovenska M, Majer P, Dauter M, Hin N, Ko YS, Tsukamoto T, Slusher BS, Konvalinka J, Lubkowski J.
Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.
J. Mol. Biol. 376: 1438-50, 2008. [Journal]
3)  Barinka C, Prahl A, Lubkowski J.
Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13).
Acta Crystallogr. D Biol. Crystallogr. 64: 273-8, 2008. [Journal]
4)  Rajabi M, de Leeuw E, Pazgier M, Li J, Lubkowski J, Lu W.
The conserved salt bridge in human alpha -defensin 5 is required for its precursor processing and proteolytic stability.
J. Biol. Chem. 2008. [Journal]
5)  Pazgier M, Lu X, Lu W, Lubkowski J.
Human defensins-structures, chemical synthesis and recombinant production.
Curr. Pharm. Des. 2007. In Press. [Journal]
6)  Barinka C, Starkova J, Konvalinka J, Lubkowski J.
A high-resolution structure of ligand-free human glutamate carboxypeptidase II.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63: 150-3, 2007. [Journal]
7)  Pazgier M, Li X, Lu W, Lubkowski J.
Human defensins: synthesis and structural properties.
Curr. Pharm. Des. 13: 3096-118, 2007. [Journal]
8)  Wu Z, Li X, Ericksen B, de Leeuw E, Zou G, Zeng P, Xie C, Li C, Lubkowski J, Lu WY, Lu W.
Impact of pro segments on the folding and function of human neutrophil alpha-defensins.
J. Mol. Biol. 368: 537-49, 2007. [Journal]
9)  Barinka C, Rovenska M, Mlcochova P, Hlouchova K, Plechanovova A, Majer P, Tsukamoto T, Slusher BS, Konvalinka J, Lubkowski J.
Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.
J. Med. Chem. 50: 3267-73, 2007. [Journal]
10)  Pazgier M, Prahl A, Hoover DM, Lubkowski J.
Studies of the biological properties of human beta-defensin 1.
J. Biol. Chem. 282: 1819-29, 2007. [Journal]
11)  Zou G, de Leeuw E, Li C, Pazgier M, Li C, Zeng P, Lu WY, Lubkowski J, Lu W.
Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.
J. Biol. Chem. 282: 19653-65, 2007. [Journal]
12)  Szyk A, Wu Z, Tucker K, Yang D, Lu W, Lubkowski J.
Crystal structures of human alpha-defensins HNP4, HD5, and HD6.
Protein Sci. 15: 2749-60, 2006. [Journal]
13)  Pazgier M, Lubkowski J.
Expression and purification of recombinant human alpha-defensins in Escherichia coli.
Protein Expr Purif. 49: 1-8, 2006. [Journal]
14)  Buck CB, Day PM, Thompson CD, Lubkowski J, Lu W, Lowy DR, Schiller JT.
Human alpha-defensins block papillomavirus infection.
Proc. Natl. Acad. Sci. U.S.A. 103: 1516-21, 2006. [Journal]
15)  Pazgiera M, Hoover DM, Yang D, Lu W, Lubkowski J.
Human beta-defensins.
Cell. Mol. Life Sci. 63: 1294-313, 2006. [Journal]
16)  Barinka C, Parry G, Callahan J, Shaw DE, Kuo A, Bdeir K, Cines DB, Mazar A, Lubkowski J.
Structural Basis of Interaction between Urokinase-type Plasminogen Activator and its Receptor.
J. Mol. Biol. 363: 482-95, 2006. [Journal]
17)  Gattis JL, Washington AV, Chisholm MM, Quigley L, Szyk A, McVicar DW, Lubkowski J.
The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment.
J. Biol. Chem. 281: 13396-403, 2006. [Journal]
18)  Wu Z, Cocchi F, Gentles D, Ericksen B, Lubkowski J, Devico A, Lehrer RI, Lu W.
Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro.
FEBS Lett. 579: 162-6, 2005. [Journal]
19)  Economopoulou M, Bdeir K, Cines DB, Fogt F, Bdeir Y, Lubkowski J, Lu W, Preissner KT, Hammes HP, Chavakis T.
Inhibition of pathological retinal neovascularization by {alpha}-defensins.
Blood. 2005. [Journal]
20)  Xie C, Prahl A, Ericksen B, Wu Z, Zeng P, Li X, Lu WY, Lubkowski J, Lu W.
Reconstruction of the conserved beta -bulge in mammalian defensins using D-amino acids.
J Biol Chem. 2005. [Journal]
21)  Yang D, Biragyn A, Hoover DM, Lubkowski J, Oppenheim JJ.
Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense.
Annu Rev Immunol. 22: 181-215, 2004. [Journal]
22)  Szyk A, Lu W, Xu C, Lubkowski J.
Structure of the scorpion toxin BmBKTtx1 solved from single wavelength anomalous scattering of sulfur.
J Struct Biol. 145: 289-94, 2004. [Journal]
23)  Wu Z, Ericksen B, Tucker K, Lubkowski J, Lu W.
Synthesis and characterization of human alpha-defensins 4-6.
J Pept Res. 64: 118-25, 2004. [Journal]
24)  Wu Z, Alexandratos J, Ericksen B, Lubkowski J, Gallo RC, Lu W.
Total chemical synthesis of N-myristoylated HIV-1 matrix protein p17: structural and mechanistic implications of p17 myristoylation.
Proc Natl Acad Sci U S A. 101: 11587-92, 2004. [Journal]
25)  Lubkowski J, Dauter M, Aghaiypour K, Wlodawer A, Dauter Z.
Atomic resolution structure of Erwinia chrysanthemi L-asparaginase.
Acta Crystallogr D Biol Crystallogr. 59: 84-92, 2003. [Journal]
26)  Prahl A, Pazgier M, Hejazi M, Lockau W, Lubkowski J.
Crystal sructure of the isoaspartyl-peptidase with L-asparaginase activity from Escherichia coli.
Acta Crystallogr D Biol Crystallogr. 60: 1173-6, 2003. [Journal]
27)  Asojo OA, Cater S, Hoover DM, Boulègue C, Lu W, Lubkowski J.
Crystallization and preliminary X-ray studies of thymus and activation-regulated chemokine (TARC).
Acta Crystallogr D Biol Crystallogr. 59: 163-5, 2003. [Journal]
28)  Wu Z, Hoover DM, Yang D, Boulègue C, Santamaria F, Oppenheim JJ, Lubkowski J, Lu W.
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3.
Proc. Natl. Acad. Sci. U.S.A. 100: 8880-5, 2003. [Journal]
29)  Wu Z, Prahl A, Powell R, Ericksen B, Lubkowski J, Lu W.
From pro defensins to defensins: synthesis and characterization of human neutrophil pro alpha-defensin-1 and its mature domain.
J. Pept. Res. 62: 53-62, 2003. [Journal]
30)  Hoover DM, Wu Z, Tucker K, Lu W, Lubkowski J.
Functional characterization of the antimicrobial activities of human beta-defensin-3 using peptide analogs.
Antimicrob. Agents Chemother. 47: 2804-9, 2003. [Journal]
31)  Asojo OA, Boulègue C, Hoover DM, Lu W, Lubkowski J.
High-resolution crystal structures of thymus and activation-regulated chemokine (TARC).
Acta Crystallogr D Biol Crystallogr. 59: 1165-73, 2003. [Journal]
32)  Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J, Oppenheim JJ.
Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
J Leukoc Biol. 74: 448-55, 2003. [Journal]
33)  Szyk A, Lu W, Xu C, Lubkowski J.
Structure of the Scorpion Toxin BmK38 Solved from Single Wavelength Anomalous Scattering of Sulfur.
Acta Crystallogr D Biol Crystallgr. 145: 289-94, 2003. [Journal]
34)  Hoover DM, Lubkowski J.
DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis.
Nucleic Acids Res. 30: e43, 2002. [Journal]
35)  Hoover DM, Boulegue C, Yang D, Oppenheim JJ, Tucker K, Lu W, Lubkowski J.
The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins.
J Biol Chem. 277: 37647-54, 2002. [Journal]
36)  Aghaiypour K, Wlodawer A, Lubkowski J.
Do bacterial L-asparaginases utilize a catalytic triad Thr-Tyr-Glu.
Biochim Biophys Acta. 1550: 117-28, 2001. [Journal]
37)  Aghaiypour K, Wlodawer A, Lubkowski J.
Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase.
Biochemistry. 40: 5655-64, 2001. [Journal]
38)  Jaskólski M, Kozak M, Lubkowski J, Palm G, Wlodawer A.
Structures of two highly homologous bacterial L-asparaginases: a case of enantiomorphic space groups.
Acta Crystallogr D Biol Crystallogr. 57: 369-77, 2001. [Journal]
39)  Hoover DM, Chertov O, Lubkowski J.
The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.
J Biol Chem. 276: 39021-6, 2001. [Journal]
40)  Hoover DM, Shaw J, Gryczynski Z, Proudfoot AEI, Wells T, Lubkowski J.
Determination of the crystal structure of Met-RANTES and comparison with native- and AOP-RANTES.
Protein Peptide Lett. 7: 73-82, 2000. [Journal]
41)  Buyong , Xiong J, Lubkowski J, Nussinov R.
Homology modeling and molecular dynamics simulations of lymphotactin.
Protein Sci. 9: 2192-9, 2000. [Journal]
42)  Hoover DM, Mizoue LS, Handel TM, Lubkowski J.
The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement.
J Biol Chem. 275: 23187-93, 2000. [Journal]
43)  Hoover DM, Rajashankar KR, Blumenthal R, Puri A, Oppenheim JJ, Chertov O, Lubkowski J.
The structure of human beta-defensin-2 shows evidence of higher order oligomerization.
J Biol Chem. 275: 32911-8, 2000. [Journal]

This page was last updated on 11/21/2008.