Our Science – Hu Website
Wei-Shau Hu, Ph.D.
Selected Publications |
1)
Moore MD, Chin MP, Hu WS. HIV-1 Recombination: An Experimental Assay and a Phylogenetic Approach. Methods Mol. Biol. 485: 87-105, 2009. [Journal] |
2)
Chen J, Pathak VK, Peng W, Hu W. Capsid proteins from human immunodeficiency virus type 1 and simian immunodeficiency virus SIVmac can coassemble into mature cores of infectious viruses. J. Virol. 82: 8253-61, 2008. [Journal] |
3)
Moore MD, Fu W, Soheilian F, Nagashima K, Ptak RG, Pathak VK, Hu W. Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: Effects on virion morphogenesis and RNA maturation. Virology. 379: 152-60, 2008. [Journal] |
4)
Moore M, Hu W. HIV-1 RNA dimerization: It takes two to tango. AIDS Rev. 2008. In Press. [Journal] |
5)
Nikolaitchik OA, Gorelick RJ, Leavitt MG, Pathak VK, Hu W. Functional complementation of nucleocapsid and late domain PTAP mutants of human immunodeficiency virus type 1 during replication. Virology. 375: 539-49, 2008. [Journal] |
6)
Motomura K, Chen J, Hu WS. Genetic recombination between human immunodeficiency virus type 1 (HIV-1) and HIV-2, two distinct human lentiviruses. J. Virol. 82: 1923-33, 2008. [Journal] |
7)
Chukkapalli V, Hogue IB, Boyko V, Hu WS, Ono A. Interaction between the human immunodeficiency virus type 1 Gag matrix domain and phosphatidylinositol-(4,5)-bisphosphate is essential for efficient gag membrane binding. J. Virol. 82: 2405-17, 2008. [Journal] |
8)
Chin MP, Lee SK, Chen J, Nikolaitchik OA, Powell DA, Fivash MJ, Hu WS. Long-range recombination gradient between HIV-1 subtypes B and C variants caused by sequence differences in the dimerization initiation signal region. J. Mol. Biol. 377: 1324-33, 2008. [Journal] |
9)
Lee SK, Boyko V, Hu WS. Capsid is an important determinant for functional complementation of murine leukemia virus and spleen necrosis virus Gag proteins. Virology. 360: 388-97, 2007. [Journal] |
10)
Thomas DC, Voronin YA, Nikolenko GN, Chen J, Hu WS, Pathak VK. Determination of the ex vivo rates of human immunodeficiency virus type 1 reverse transcription by using novel strand-specific amplification analysis. J. Virol. 81: 4798-807, 2007. [Journal] |
11)
Moore MD, Fu W, Nikolaitchik O, Chen J, Ptak RG, Hu WS. Dimer initiation signal of human immunodeficiency virus type 1: its role in partner selection during RNA copackaging and its effects on recombination. J. Virol. 81: 4002-11, 2007. [Journal] |
12)
Chin MP, Chen J, Nikolaitchik OA, Hu WS. Molecular determinants of HIV-1 intersubtype recombination potential. Virology. 363: 437-46, 2007. [Journal] |
13)
Fu W, Prasad VV, Chen J, Nikolaitchik O, Hu WS. Molecular mechanisms of simian immunodeficiency virus SIV(agm) RNA encapsidation. Virology. 363: 210-9, 2007. [Journal] |
14)
Xu H, Chertova E, Chen J, Ott DE, Roser JD, Hu WS, Pathak VK. Stoichiometry of the antiviral protein APOBEC3G in HIV-1 virions. Virology. 360: 247-56, 2007. [Journal] |
15)
Boyko V, Leavitt M, Gorelick R, Fu W, Nikolaitchik O, Pathak VK, Nagashima K, Hu WS. Coassembly and Complementation of Gag Proteins from HIV-1 and HIV-2, Two Distinct Human Pathogens. Mol. Cell. 23: 281-7, 2006. [Journal] |
16)
Fu W, Dang Q, Nagashima K, Freed EO, Pathak VK, Hu WS. Effects of Gag mutation and processing on retroviral dimeric RNA maturation. J Virol. 80: 1242-9, 2006. [Journal] |
17)
Nikolaitchik O, Rhodes TD, Ott D, Hu WS. Effects of mutations in the human immunodeficiency virus type 1 Gag gene on RNA packaging and recombination. J Virol. 80: 4691-7, 2006. [Journal] |
18)
Chen J, Powell D, Hu WS. High frequency of genetic recombination is a common feature of primate lentivirus replication. J. Virol. 80: 9651-8, 2006. [Journal] |
19)
Chen J, Rhodes TD, Hu WS. Comparison of the genetic recombination rates of human immunodeficiency virus type 1 in macrophages and T cells. J Virol. 79: 9337-40, 2005. [Journal] |
20)
Lee SK, Nagashima K, Hu WS. Cooperative effect of Gag proteins p12 and capsid during early events of murine leukemia virus replication. J Virol. 79: 4159-69, 2005. [Journal] |
21)
Rhodes TD, Nikolaitchik O, Chen J, Powell D, Hu WS. Genetic recombination of human immunodeficiency virus type 1 in one round of viral replication: Effects of genetic distance, target cells, accessory genes, and lack of high negative interference in crossover events. J Virol. 79: 1666-77, 2005. [Journal] |
22)
Chin MP, Rhodes TD, Chen J, Fu W, Hu WS. Identification of a major restriction in HIV-1 intersubtype recombination. Proc Natl Acad Sci U S A. 102: 9002-9007, 2005. [Journal] |
23)
Chen J, Dang Q, Unutmaz D, Pathak VK, Maldarelli F, Powell D, Hu WS. Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: preference in virus entry is important but is not the sole factor. J Virol. 79: 4140-9, 2005. [Journal] |
24)
Svarovskaia ES, Xu H, Mbisa JL, Barr R, Gorelick RJ, Ono A, Freed EO, Hu WS, Pathak VK. Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs. J Biol Chem. 279: 35822-8, 2004. [Journal] |
25)
Dang Q, Chen J, Unutmaz D, Coffin JM, Pathak VK, Powell D, KewalRamani VN, Maldarelli F, Hu WS. Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways. Proc Natl Acad Sci U S A. 101: 632-7, 2004. [Journal] |
26)
Cheslock SR, Poon DT, Fu W, Rhodes TD, Henderson LE, Nagashima K, McGrath CF, Hu WS. Charged assembly helix motif in murine leukemia virus capsid: an important region for virus assembly and particle size determination. J Virol. 77: 7058-66, 2003. [Journal] |
27)
Fu W, Hu WS. Functional replacement of nucleocapsid flanking regions by heterologous counterparts with divergent primary sequences: effects of chimeric nucleocapsid on the retroviral replication cycle. J Virol. 77: 754-61, 2003. [Journal] |
28)
Rhodes T, Wargo H, Hu WS. High rates of human immunodeficiency virus type 1 recombination: near-random segregation of markers one kilobase apart in one round of viral replication. J Virol. 77: 11193-200, 2003. [Journal] |
29)
Svarovskaia ES, Cheslock SR, Zhang WH, Hu WS, Pathak VK. Retroviral mutation rates and reverse transcriptase fidelity. Front Biosci. 8: D117-34, 2003. [Journal] |
30)
Hu WS, Rhodes T, Dang Q, Pathak V. Retroviral recombination: review of genetic analyses. Front Biosci. 8: D143-55, 2003. [Journal] |
31)
Beasley BE, Hu WS. cis-Acting elements important for retroviral RNA packaging specificity. J Virol. 76: 4950-60, 2002. [Journal] |
32)
Zhang WH, Hwang CK, Hu WS, Gorelick RJ, Pathak VK. Zinc finger domain of murine leukemia virus nucleocapsid protein enhances the rate of viral DNA synthesis in vivo. J Virol. 76: 7473-84, 2002. [Journal] |
33)
Dang Q, Hu WS. Effects of homology length in the repeat region on minus-strand DNA transfer and retroviral replication. J Virol. 75: 809-20, 2001. [Journal] |
34)
Hu WS, Pathak VK. Design of retroviral vectors and helper cells for gene therapy. Pharmacol Rev. 52: 493-511, 2000. [Journal] |
35)
Anderson JA, Pathak VK, Hu WS. Effect of the murine leukemia virus extended packaging signal on the rates and locations of retroviral recombination. J Virol. 74: 6953-63, 2000. [Journal] |
36)
Cheslock SR, Anderson JA, Hwang CK, Pathak VK, Hu WS. Utilization of nonviral sequences for minus-strand DNA transfer and gene reconstitution during retroviral replication. J Virol. 74: 9571-9, 2000. [Journal] |
37)
Pathak V, Hu W, inventor; DHHS, assignee. Safe Vectors for Gene Therapy. US Patent: 5,741,486. 1998. [Patent] |
38)
Pathak V, Hu W, inventor; DHHS, assignee. Safe Vectors for Gene Therapy. US Patent: 5,714,353. 1998. [Patent] |
39)
Hu W, Pathak V, inventor; DHHS, assignee. Utilization of Non-viral Sequences for Minus-strand DNA Transfer and Gene Reconstitution. US Patent: 7,101,541. 2006. [Patent] |
This page was last updated on 12/2/2008.