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Our Science – Hu Website

Wei-Shau Hu, Ph.D.

Selected Publications
1)  Moore MD, Chin MP, Hu WS.
HIV-1 Recombination: An Experimental Assay and a Phylogenetic Approach.
Methods Mol. Biol. 485: 87-105, 2009. [Journal]
2)  Chen J, Pathak VK, Peng W, Hu W.
Capsid proteins from human immunodeficiency virus type 1 and simian immunodeficiency virus SIVmac can coassemble into mature cores of infectious viruses.
J. Virol. 82: 8253-61, 2008. [Journal]
3)  Moore MD, Fu W, Soheilian F, Nagashima K, Ptak RG, Pathak VK, Hu W.
Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: Effects on virion morphogenesis and RNA maturation.
Virology. 379: 152-60, 2008. [Journal]
4)  Moore M, Hu W.
HIV-1 RNA dimerization: It takes two to tango.
AIDS Rev. 2008. In Press. [Journal]
5)  Nikolaitchik OA, Gorelick RJ, Leavitt MG, Pathak VK, Hu W.
Functional complementation of nucleocapsid and late domain PTAP mutants of human immunodeficiency virus type 1 during replication.
Virology. 375: 539-49, 2008. [Journal]
6)  Motomura K, Chen J, Hu WS.
Genetic recombination between human immunodeficiency virus type 1 (HIV-1) and HIV-2, two distinct human lentiviruses.
J. Virol. 82: 1923-33, 2008. [Journal]
7)  Chukkapalli V, Hogue IB, Boyko V, Hu WS, Ono A.
Interaction between the human immunodeficiency virus type 1 Gag matrix domain and phosphatidylinositol-(4,5)-bisphosphate is essential for efficient gag membrane binding.
J. Virol. 82: 2405-17, 2008. [Journal]
8)  Chin MP, Lee SK, Chen J, Nikolaitchik OA, Powell DA, Fivash MJ, Hu WS.
Long-range recombination gradient between HIV-1 subtypes B and C variants caused by sequence differences in the dimerization initiation signal region.
J. Mol. Biol. 377: 1324-33, 2008. [Journal]
9)  Lee SK, Boyko V, Hu WS.
Capsid is an important determinant for functional complementation of murine leukemia virus and spleen necrosis virus Gag proteins.
Virology. 360: 388-97, 2007. [Journal]
10)  Thomas DC, Voronin YA, Nikolenko GN, Chen J, Hu WS, Pathak VK.
Determination of the ex vivo rates of human immunodeficiency virus type 1 reverse transcription by using novel strand-specific amplification analysis.
J. Virol. 81: 4798-807, 2007. [Journal]
11)  Moore MD, Fu W, Nikolaitchik O, Chen J, Ptak RG, Hu WS.
Dimer initiation signal of human immunodeficiency virus type 1: its role in partner selection during RNA copackaging and its effects on recombination.
J. Virol. 81: 4002-11, 2007. [Journal]
12)  Chin MP, Chen J, Nikolaitchik OA, Hu WS.
Molecular determinants of HIV-1 intersubtype recombination potential.
Virology. 363: 437-46, 2007. [Journal]
13)  Fu W, Prasad VV, Chen J, Nikolaitchik O, Hu WS.
Molecular mechanisms of simian immunodeficiency virus SIV(agm) RNA encapsidation.
Virology. 363: 210-9, 2007. [Journal]
14)  Xu H, Chertova E, Chen J, Ott DE, Roser JD, Hu WS, Pathak VK.
Stoichiometry of the antiviral protein APOBEC3G in HIV-1 virions.
Virology. 360: 247-56, 2007. [Journal]
15)  Boyko V, Leavitt M, Gorelick R, Fu W, Nikolaitchik O, Pathak VK, Nagashima K, Hu WS.
Coassembly and Complementation of Gag Proteins from HIV-1 and HIV-2, Two Distinct Human Pathogens.
Mol. Cell. 23: 281-7, 2006. [Journal]
16)  Fu W, Dang Q, Nagashima K, Freed EO, Pathak VK, Hu WS.
Effects of Gag mutation and processing on retroviral dimeric RNA maturation.
J Virol. 80: 1242-9, 2006. [Journal]
17)  Nikolaitchik O, Rhodes TD, Ott D, Hu WS.
Effects of mutations in the human immunodeficiency virus type 1 Gag gene on RNA packaging and recombination.
J Virol. 80: 4691-7, 2006. [Journal]
18)  Chen J, Powell D, Hu WS.
High frequency of genetic recombination is a common feature of primate lentivirus replication.
J. Virol. 80: 9651-8, 2006. [Journal]
19)  Chen J, Rhodes TD, Hu WS.
Comparison of the genetic recombination rates of human immunodeficiency virus type 1 in macrophages and T cells.
J Virol. 79: 9337-40, 2005. [Journal]
20)  Lee SK, Nagashima K, Hu WS.
Cooperative effect of Gag proteins p12 and capsid during early events of murine leukemia virus replication.
J Virol. 79: 4159-69, 2005. [Journal]
21)  Rhodes TD, Nikolaitchik O, Chen J, Powell D, Hu WS.
Genetic recombination of human immunodeficiency virus type 1 in one round of viral replication: Effects of genetic distance, target cells, accessory genes, and lack of high negative interference in crossover events.
J Virol. 79: 1666-77, 2005. [Journal]
22)  Chin MP, Rhodes TD, Chen J, Fu W, Hu WS.
Identification of a major restriction in HIV-1 intersubtype recombination.
Proc Natl Acad Sci U S A. 102: 9002-9007, 2005. [Journal]
23)  Chen J, Dang Q, Unutmaz D, Pathak VK, Maldarelli F, Powell D, Hu WS.
Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: preference in virus entry is important but is not the sole factor.
J Virol. 79: 4140-9, 2005. [Journal]
24)  Svarovskaia ES, Xu H, Mbisa JL, Barr R, Gorelick RJ, Ono A, Freed EO, Hu WS, Pathak VK.
Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.
J Biol Chem. 279: 35822-8, 2004. [Journal]
25)  Dang Q, Chen J, Unutmaz D, Coffin JM, Pathak VK, Powell D, KewalRamani VN, Maldarelli F, Hu WS.
Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways.
Proc Natl Acad Sci U S A. 101: 632-7, 2004. [Journal]
26)  Cheslock SR, Poon DT, Fu W, Rhodes TD, Henderson LE, Nagashima K, McGrath CF, Hu WS.
Charged assembly helix motif in murine leukemia virus capsid: an important region for virus assembly and particle size determination.
J Virol. 77: 7058-66, 2003. [Journal]
27)  Fu W, Hu WS.
Functional replacement of nucleocapsid flanking regions by heterologous counterparts with divergent primary sequences: effects of chimeric nucleocapsid on the retroviral replication cycle.
J Virol. 77: 754-61, 2003. [Journal]
28)  Rhodes T, Wargo H, Hu WS.
High rates of human immunodeficiency virus type 1 recombination: near-random segregation of markers one kilobase apart in one round of viral replication.
J Virol. 77: 11193-200, 2003. [Journal]
29)  Svarovskaia ES, Cheslock SR, Zhang WH, Hu WS, Pathak VK.
Retroviral mutation rates and reverse transcriptase fidelity.
Front Biosci. 8: D117-34, 2003. [Journal]
30)  Hu WS, Rhodes T, Dang Q, Pathak V.
Retroviral recombination: review of genetic analyses.
Front Biosci. 8: D143-55, 2003. [Journal]
31)  Beasley BE, Hu WS.
cis-Acting elements important for retroviral RNA packaging specificity.
J Virol. 76: 4950-60, 2002. [Journal]
32)  Zhang WH, Hwang CK, Hu WS, Gorelick RJ, Pathak VK.
Zinc finger domain of murine leukemia virus nucleocapsid protein enhances the rate of viral DNA synthesis in vivo.
J Virol. 76: 7473-84, 2002. [Journal]
33)  Dang Q, Hu WS.
Effects of homology length in the repeat region on minus-strand DNA transfer and retroviral replication.
J Virol. 75: 809-20, 2001. [Journal]
34)  Hu WS, Pathak VK.
Design of retroviral vectors and helper cells for gene therapy.
Pharmacol Rev. 52: 493-511, 2000. [Journal]
35)  Anderson JA, Pathak VK, Hu WS.
Effect of the murine leukemia virus extended packaging signal on the rates and locations of retroviral recombination.
J Virol. 74: 6953-63, 2000. [Journal]
36)  Cheslock SR, Anderson JA, Hwang CK, Pathak VK, Hu WS.
Utilization of nonviral sequences for minus-strand DNA transfer and gene reconstitution during retroviral replication.
J Virol. 74: 9571-9, 2000. [Journal]
37)  Pathak V, Hu W, inventor; DHHS, assignee.
Safe Vectors for Gene Therapy.
US Patent: 5,741,486. 1998. [Patent]
38)  Pathak V, Hu W, inventor; DHHS, assignee.
Safe Vectors for Gene Therapy.
US Patent: 5,714,353. 1998. [Patent]
39)  Hu W, Pathak V, inventor; DHHS, assignee.
Utilization of Non-viral Sequences for Minus-strand DNA Transfer and Gene Reconstitution.
US Patent: 7,101,541. 2006. [Patent]

This page was last updated on 12/2/2008.