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Attenuated Listeria monocytogenes strain CRS-207 (inlB & actA deleted)
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CRS-207 is a live attenuated strain of Listeria monocytogenes genomically deleted for the entire coding sequence of two virulence-determinant genes inlB and actA. These two genes facilitate invasion of non-phagocytic cells and cell-to-cell spread, respectively. The combined deletion of these two genes results in more than a 1,000-fold decrease in virulence as measured in a mouse model.
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Attenuated Listeria monocytogenes strain XFL-7 (prfA modified)
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This strain of Listeria is attenuated by modification of the prfA gene, a major pluripotent virulence factor that is required for replication. The modified prfA gene results in a partial complementation of function that increases the LD50 in mice by 3 logs in comparison to wild-type.
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Attenuated Salmonella typhimurium strain VNP20029
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Stably transduced Salmonella strain (VNP20009) that contains the E. coli Cytosine Deaminase gene in the bacterial chromosome locus msbB.
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Bacterial cells
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Established allogeneic adenocarcinoma cells
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Adenocarcinoma cells from an individual that demonstrate the potential for indefinite subculture in vitro for implantation into another individual.
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Established allogeneic breast adenocarcinoma cells MDA-MB-231
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The cell line is aneuploid female, with chromosome counts in the near-triploid range. Normal chromosomes N8 and N15 were absent. Eleven stable rearranged marker chromosomes are noted as well as unassignable chromosomes in addition to the majority of autosomes that are trisomic.
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Established allogeneic breast cancer cells
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Breast cancer cells from an individual that demonstrate the potential for indefinite subculture in vitro that are re-implanted into another individual from the same species
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Established allogeneic breast cancer cells estrogen / progesterone receptor negative BT-20
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This breast tumor line was established by E.Y. Lasfargues and L. Ozzello in 1958 by isolation and cultivation of cells spilling out of the tumor when it was cut in thin slices. A mycoplasma contaminant was discovered and eliminated early in 1972. Growth of BT-20 cells is inhibited by tumor necrosis factor alpha (TNF alpha). BT-20 cells are negative for estrogen receptor, but do express an estrogen receptor mRNA that has deletion of exon 5.
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Established allogeneic breast cancer cells estrogen / progesterone receptor positive MCF-7
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The MCF7 line retains several characteristics of differentiated mammary epithelium including ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes. Contains the Tx-4 oncogene. Growth of MCF7 cells is inhibited by tumor necrosis factor alpha (TNF alpha). Secretion of IGFBP's can be modulated by treatment with anti-estrogens.
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Established allogeneic cells
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Cells from individual that demonstrate the potential for indefinite subculture in vitro that are re-implanted into another individual from the same species.
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