Summaries & Associations of Study Results
TR-440 Ozone (2-year study)
Target Organs and Levels of Evidence
NTP Technical Report Number 440
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| OZONE 10028-15-6 |
11/16/93 | POLLUTION CONTROL, WASTE TREATMENT, CHEMICAL SYNTHESIS, STERILIZATION WHERE RESIDUALS OF OTHER CHEMICALS WOULD BE OBJECTIONABLE, ODOR CONTROL, BLEACHING WAXES, CLAY, TEXTILES, PAPER PULP, OILS, CONTROL OF ALGAE, MOLD, AND BACTERIA | Inhalation R&M: 0, 0.12, 0.5, OR 1.0 PPM (50/SEX/SPECIES/GROUP) | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | NOSE: (2 YR. STUDY) GOBLET CELL AND LATERAL WALL HYPERPLASIA; SQUAMOUS METAPLASIA | |||
| LARYNX: (2 YR. STUDY) SQUAMOUS METAPLASIA | ||||
| LUNG: (2 YR. STUDY) METAPLASIA; INTERSTITIAL FIBROSIS | ||||
| FR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | NOSE: (2 YR. STUDY) GOBLET CELL AND LATERAL WALL HYPERPLASIA; SQUAMOUS METAPLASIA | |||
| LARYNX: (2 YR. STUDY) SQUAMOUS METAPLASIA | ||||
| LUNG: (2 YR. STUDY) METAPLASIA; INTERSTITIAL FIBROSIS | ||||
| MM: EQUIVOCAL EVIDENCE | LUNG: (2 YR. STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 9/50 12/50 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 8/50 4/50 8/50 10/50 COMBINED 14/50 13/50 18/50 19/50 | |||
| NON-NEOPLASTIC LESIONS: | NOSE: (2 YR. STUDY) HYPERPLASIA; SQUAMOUS METAPLASIA | |||
| LARYNX: (2 YR. STUDY) HYPERPLASIA | ||||
| LUNG: (2 YR. STUDY) HISTIOCYTIC INFILTRATION; METAPLASIA | ||||
| FM: SOME EVIDENCE | LUNG: (2 YR. STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 5/50 5/49 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 2/50 5/49 8/50 COMBINED 6/50 7/50 9/49 16/50 | |||
| NON-NEOPLASTIC LESIONS: | NOSE: (2 YR. STUDY) HYPERPLASIA; SQUAMOUS METAPLASIA | |||
| LARYNX: (2 YR. STUDY) HYPERPLASIA | ||||
| LUNG: (2 YR. STUDY) HISTIOCYCTIC INFILTRATION; METAPLASIA | ||||
| OZONE 10028-15-6 |
11/16/93 | POLLUTION CONTROL, WASTE TREATMENT, CHEMICAL SYNTHESIS, STERILIZATION WHERE RESIDUALS OF OTHER CHEMICALS WOULD BE OBJECTIONABLE, ODOR CONTROL, BLEACHING WAXES, CLAY, TEXTILES, PAPER PULP, OILS, CONTROL OF ALGAE, MOLD, AND BACTERIA | Inhalation R&M: 0, 0.5, OR 1.0 PPM (50/SEX/SPECIES/GROUP) | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | NOSE: (LIFETIME STUDY) GOBLET CELL AND LATERAL WALL HYPERPLASIA; SQUAMOUS METAPLASIA | |||
| LARYNX: (LIFETIME STUDY) SQUAMOUS METAPLASIA | ||||
| LUNG: (LIFETIME STUDY) METAPLASIA; HISTIOCYTIC INFILTRATION; INTERSTITIAL FIBROSIS | ||||
| FR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | NOSE: (LIFETIME STUDY) GOBLET CELL AND LATERAL WALL HYPERPLASIA; SQUAMOUS METAPLASIA | |||
| LARYNX: (LIFETIME STUDY) SQUAMOUS METAPLASIA | ||||
| LUNG: (LIFETIME STUDY) METAPLASIA; HISTIOCYTIC INFILTRATION; INTERSTITIAL FIBROSIS | ||||
| MM: EQUIVOCAL EVIDENCE | LUNG: (LIFETIME STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 8/49 8/49 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 8/49 15/49 18/50 COMBINED 16/49 22/49 21/50 | |||
| NON-NEOPLASTIC LESIONS: | NOSE: (LIFETIME STUDY) HYPERPLASIA; SQUAMOUS METAPLASIA | |||
| LARYNX: (LIFETIME STUDY) HYPERPLASIA; SQUAMOUS CELL METAPLASIA | ||||
| LUNG: (LIFETIME STUDY) HISTIOCYTIC INFILTRATION; METAPLASIA | ||||
| FM: SOME EVIDENCE | LUNG: (LIFETIME STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 3/49 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 5/49 2/50 COMBINED 6/50 8/49 12/50 | |||
| NON-NEOPLASTIC LESIONS: | NOSE: (LIFETIME STUDY) HYPERPLASIA; SQUAMOUS METAPLASIA | |||
| LARYNX: (LIFETIME STUDY) HYPERPLASIA; SQUAMOUS CELL METAPLASIA | ||||
| LUNG: (LIFETIME STUDY) HISTIOCYTIC INFILTRATION; METAPLASIA | ||||
| OZONE/NNK OZONNNKCOMB |
11/16/93 | BYPRODUCT OF TOBACCO SMOKE | Inhalation MALE RATS ONLY: 0, 0.5 PPM OZONE WITH 0, 0.1, 1.0 MG/KG NNK BY S.C. INJECTION (20 WEEKS ONLY) | Battelle Northwest Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| NOTE: | IN A COCARCINOGENICITY STUDY, OZONE DID NOT ENHANCE NNK-INDUCED PULMONARY NEOPLASMS IN MALE RATS | |||
Web page last updated on February 10, 2006
