Testing Information

Testing Status of Agents at NTP

Ozone/NNK

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http://ntp.niehs.nih.gov/go/TS-M890006

CASRN: OZONNNKCOMB

Related: OZONE

Formula: C10-H13-N3-O2

Synonyms/Common Names:

  • 1-BUTANONE, 4-(METHYLNITROSOAMINO)-1-3-PYRIDINYL)- (9CI)
  • NNK

Secondary:

  • 64091-91-4 - 4-(N-Nitroso-N-methylamino)-1-(3-pyridyl)-1-butanone
  • 10028-15-6 - Ozone
  • 10028-15-6 - Ozone (Airways Disease Project)

Known Uses:

BYPRODUCT OF TOBACCO SMOKE

Long-Term Carcinogenicity

  • 2-YEAR (Inhalation)  (C88034C) Report Complete 
    • TR-440 (NTIS No. PB95-226999)  (Peer Review 11/16/1993)
      Toxicology and Carcinogenesis Studies of Ozone (CAS No. 10028-15-6) and Ozone/NNK (CAS No. 10028-15-6/ 64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N
    • Dose: MALE RATS ONLY: 0, 0.5 PPM OZONE WITH 0, 0.1, 1.0 MG/KG NNK BY S.C. INJECTION (20 WEEKS ONLY)

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Web page last updated on April 27, 2009