Alternatives
According to the Animal Welfare Act regulations, "the ACUC shall determine that the principal investigator has considered alternatives to procedures that may cause more than slight pain or distress to the animals, and has provided a written narrative of the methods and sources used to determine that alternatives were not available." The ACUC is also responsible for ensuring that the proposed research does not unnecessarily duplicate other research.
While there are various sections of the NCI-Frederick Animal Study Proposal that address the issue of alternative considerations and non-duplicative research, the ACUC will require a database reference search for all studies (regardless of species) that propose Category 3 (unrelieved pain or generalized discomfort) procedures. In these situations, the PI is required to provide the ACUC with the following information under Section G of the NCI Animal Study Proposal form to demonstrate good-faith effort: (1) a statement describing the consideration of alternatives to procedures listed for Category 3 ; (2) the PI's determination that alternatives were not available for use in his/her study; and (3) a database reference statement to include the databases searched, the date of the search, period covered, and keywords used.
The following bibliographic databases can be utilized to assist with an investigator's database reference search:
Altweb
Agricola
Biological Abstracts
Embase
ISI Web of Science
Pubmed
Scopus
The following sites provide additional information on animal welfare and alternatives:
ALTBIB: Bibliography on Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing
ALTWEB
Alternatives to Skin Irritation/Corrosion Testing in Animals
Animal Welfare Institute
AWIC Alternatives and Database Searching
Developmental Studies Hybridoma Bank (University of Iowa)
Johns Hopkins Center for Alternatives to Animal Testing
IACUC.org
ICCVAM (The Interagency Coordinating Committee on the Validation of Alternative Methods)
Multicentre Evaluation of In Vitro Cytotoxicity
National Agricultural Library Animal Use Alternatives Thesaurus
National Library of Medicine – Bibliography on Alternatives to Animal Testing
Netherlands Centre Alternatives to Animal Use
NIH Library - Alternatives in Animal Research Training
Nordic Information Centre for Alternative Methods
The Norwegian Reference Centre for Laboratory Animal Science and Alternatives
OLAW Report on Production of Monoclonal Antibodies Using Mouse Ascites Method
Scirus
TextBase
UC Davis Center for Animal Alternatives
ZEBET (Center for Documentation and Evaluation of Alternative Methods to Animal Experiments)
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