| | Other Issues: previous | next | latest | archiveCommentaries Flaws in design, analysis and interpretation of Pfizer's antifungal trials of voriconazole and uncritical subsequent quotations Karsten J Jørgensen, Helle Krogh Johansen, and Peter C Gøtzsche PMCID: PMC1399447 Issues of informed consent for intrapartum trials: a suggested consent pathway from the experience of the Release trial [ISRCTN13204258] Gillian Vernon, Zarko Alfirevic, and Andrew Weeks PMCID: PMC1481528 Whose data set is it anyway? Sharing raw data from randomized trials Andrew J Vickers PMCID: PMC1489946 Editorial Lead editorial: Trials – using the opportunities of electronic publishing to improve the reporting of randomised trials Douglas G Altman, Curt D Furberg, Jeremy M Grimshaw, and Peter M Rothwell PMCID: PMC1449870 Letter to the Editor CRASH2 in Germany [ISRCTN86750102] CH Chung, A Freiberger, M Kalkum, SP Luntz, H Shakur, and CM Seiler PMCID: PMC1552086 Methodology Selecting patients for randomized trials: a systematic approach based on risk group Andrew J Vickers, Barry S Kramer, and Stuart G Baker PMCID: PMC1609186 Research What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies Alison M McDonald, Rosemary C Knight, Marion K Campbell, Vikki A Entwistle, Adrian M Grant, Jonathan A Cook, Diana R Elbourne, David Francis, Jo Garcia, Ian Roberts, and Claire Snowdon PMCID: PMC1475627 Increasing participation of cancer patients in randomised controlled trials: a systematic review Catriona Mc Daid, Zoé Hodges, Debra Fayter, Lisa Stirk, and Alison Eastwood PMCID: PMC1489947 Lessons and implications from a mass immunization campaign in squatter settlements of Karachi, Pakistan: an experience from a cluster-randomized double-blinded vaccine trial [NCT00125047] Mohammad Imran Khan, Rion Leon Ochiai, Hasan Bin Hamza, Shah Muhammad Sahito, Muhammad Atif Habib, Sajid Bashir Soofi, Naveed Sarwar Bhutto, Shahid Rasool, Mahesh K Puri, Mohammad Ali, Shafi Mohammad Wasan, Mohammad Jawed Khan, Remon Abu-Elyazeed, Bernard Ivanoff, Claudia M Galindo, Tikki Pang, Allan Donner, Lorenz von Seidlein, Camilo J Acosta, John D Clemens, Shaikh Qamaruddin Nizami, and Zulfiqar A Bhutta PMCID: PMC1513251 Factors associated with compliance and non-compliance by physicians in a large-scale randomized clinical trial Koji Oba, Satoshi Morita, Mahbubur Rahman, and Junichi Sakamoto PMCID: PMC1563475 Duty, desire or indifference? A qualitative study of patient decisions about recruitment to an epilepsy treatment trial Krysia Canvin and Ann Jacoby PMCID: PMC1770934 Financial considerations in the conduct of multi-centre randomised controlled trials: evidence from a qualitative study Claire Snowdon, Diana R Elbourne, Jo Garcia, Marion K Campbell, Vikki A Entwistle, David Francis, Adrian M Grant, Rosemary C Knight, Alison M McDonald, and Ian Roberts PMCID: PMC1781076 Comparison of the efficacy and safety of rosuvastatin 10 mg and atorvastatin 20 mg in high-risk patients with hypercholesterolemia – Prospective study to evaluate the Use of Low doses of the Statins Atorvastatin and Rosuvastatin (PULSAR) Michael B Clearfield, John Amerena, Jean-Pierre Bassand, Hugo R Hernández García, Sam S Miller, Froukje FM Sosef, Michael K Palmer, and Brian S Bryzinski PMCID: PMC1779361 Study Protocol The internal thoracic artery skeletonization study: A paired, within-patient comparison [NCT00265499] Munir Boodhwani, Howard J Nathan, B Khanh Lam, and Fraser D Rubens PMCID: PMC1399446 Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784] Behzad Eftekhar, Mohammad Ghodsi, Azar Hadadi, Mousa Taghipoor, Samira Zabihyan Sigarchi, Vafa Rahimi-Movaghar, Ehsan Sherafat Kazemzadeh, Babak Esmaeeli, Farideh Nejat, Alireza Yalda, and Ebrahim Ketabchi PMCID: PMC1402327 A multi-centre randomized controlled trial comparing electrothermal arthroscopic capsulorrhaphy versus open inferior capsular shift for patients with shoulder instability: Protocol implementation and interim performance: Lessons learned from conducting a multi-centre RCT [ISRCTN68224911; NCT00251160] NG Mohtadi, RM Hollinshead, PJ Ceponis, DS Chan, and GH Fick PMCID: PMC1399448 Multifactorial day hospital intervention to reduce falls in high risk older people in primary care: a multi-centre randomised controlled trial [ISRCTN46584556] Tahir Masud, Carol Coupland, Avril Drummond, John Gladman, Denise Kendrick, Tracey Sach, Rowan Harwood, Pradeep Kumar, Rob Morris, Rachael Taylor, Jane Youde, and Simon Conroy PMCID: PMC1420328 Protocol for the Arterial Revascularisation Trial (ART). A randomised trial to compare survival following bilateral versus single internal mammary grafting in coronary revascularisation [ISRCTN46552265] David P Taggart, Belinda Lees, Alastair Gray, Douglas G Altman, Marcus Flather, Keith Channon, and the ART Investigators PMCID: PMC1450314 Multifactorial approach and superior treatment efficacy in renal patients with the aid of nurse practitioners. Design of The MASTERPLAN Study [ISRCTN73187232] Arjan D van Zuilen, Ingeborgh van der Tweel, Peter J Blankestijn, Michiel L Bots, Marjolijn van Buren, Marc AGJ ten Dam, Karin AH Kaasjager, Peter JG van de Ven, Gerald Vervoort, Louis-Jean Vleming, Gerry Ligtenberg, Jack FM Wetzels, and the MASTERPLAN study group PMCID: PMC1459200 The effects of organic nitrates on osteoporosis: a randomized controlled trial [ISRCTN94484747] Sophie A Jamal, Celeste J Hamilton, Dennis Black, and Steven R Cummings PMCID: PMC1471803 Protocol for the 'e-Nudge trial': a randomised controlled trial of electronic feedback to reduce the cardiovascular risk of individuals in general practice [ISRCTN64828380] Tim A Holt, Margaret Thorogood, Frances Griffiths, and Stephen Munday PMCID: PMC1471804 Duodenum preserving pancreatectomy in chronic pancreatitis: Design of a randomized controlled trial comparing two surgical techniques [ISRCTN50638764] Jörg Köninger, Christoph M Seiler, Moritz N Wente, Margot A Reidel, Emre Gazyakan, Ulrich Mansmann, Michael W Müller, Helmut Friess, and Markus W Büchler PMCID: PMC1479366 Double blind, randomized controlled trial, to evaluate the effectiveness of a controlled nitric oxide releasing patch versus meglumine antimoniate in the treatment of cutaneous leishmaniasis [NCT00317629] Sandra Y Silva, Ligia C Rueda, Marcos López, Iván D Vélez, Christian F Rueda-Clausen, Daniel J Smith, Gerardo Muñoz, Hernando Mosquera, Federico A Silva, Adriana Buitrago, Holger Díaz, and Patricio López-Jaramillo PMCID: PMC1524981 1Design of the Primary Prevention Parameters Evaluation (PREPARE) trial of implantablecardioverter defibrillators to reduce patient morbidity [NCT00279279] Bruce L Wilkoff, Richard Stern, Brian Williamson, Mark Wathen, Keith Holloman, Ann Fieberg, and Mark Brown PMCID: PMC1524810 A randomized clinical trial of unfractioned heparin for treatment of sepsis (the HETRASE study): design and rationale [NCT00100308] Fabián Jaimes, Gisela De La Rosa, Clara Arango, Fernando Fortich, Carlos Morales, Daniel Aguirre, and Pablo Patiño PMCID: PMC1482716 Comparison of Venae Sectio vs. modified Seldinger Technique for Totally Implantable Access Ports; Portas-trial [ISRCTN:52368201] P Knebel, B Fröhlich, H-P Knaebel, P Kienle, S Luntz, MW Buchler, and CM Seiler PMCID: PMC1550252 CHARITY: Chagas cardiomyopathy bisoprolol intervention study: a randomized double-blind placebo force-titration controlled study with Bisoprolol in patients with chronic heart failure secondary to Chagas cardiomyopathy [NCT00323973] Franklin R Quiros, Carlos A Morillo, Juan P Casas, Luz A Cubillos, and Federico A Silva PMCID: PMC1538628 Sub-vastus approach versus the medial parapatellar approach in primary total knee: a randomised controlled trial [ISRCTN44544446] Stephen Bridgman, Gayle Walley, Gilbert MacKenzie, Darren Clement, David Griffiths, and Nicola Maffulli PMCID: PMC1553468 Double blind randomized placebo-controlled trial on the effects of testosterone supplementation in elderly men with moderate to low testosterone levels: design and baseline characteristics [ISRCTN23688581] Hamid Reza Nakhai Pour, Marielle H Emmelot-Vonk, Marja Sukel-Helleman, Harald JJ Verhaar, Diederick E Grobbee, and Yvonne T van der Schouw PMCID: PMC1563476 Will availability of inhaled human insulin (Exubera®) improve management of type 2 diabetes? The design of the Real World trial Nick Freemantle, Thomas R Strack, and the Real World Trialists PMCID: PMC1564148 Protocol design and current status of CLIVIT: a randomized controlled multicenter relevance trial comparing clips versus ligatures in thyroid surgery CM Seiler, BE Fröhlich, JA Veit, E Gazyakan, MN Wente, C Wollermann, A Deckert, S Witte, N Victor, MW Buchler, and HP Knaebel PMCID: PMC1586210 A randomized, double blind, cross-over, placebo-controlled clinical trial to assess the effects of Candesartan on the insulin sensitivity on non diabetic, non hypertense subjects with dysglyce mia and abdominal obesity. "ARAMIA" Patricio López-Jaramillo, Lina P Pradilla, Vicente Lahera, Federico A Silva Sieger, Christian F Rueda-Clausen, and Gustavo A Márquez PMCID: PMC1594582 Hemicraniectomy after middle cerebral artery infarction with life-threatening Edema trial (HAMLET). Protocol for a randomised controlled trial of decompressive surgery in space-occupying hemispheric infarction Jeannette Hofmeijer, G Johan Amelink, Ale Algra, Jan van Gijn, Malcolm R Macleod, L Jaap Kappelle, H Bart van der Worp, and the HAMLET investigators PMCID: PMC1570365 Acetylsalicylic acid as an adjuvant therapy for schizophrenia Wijnand Laan, Jean-Paul Selten, René S Kahn, Anne-Margriet Huisman, Cobi J Heijnen, Diederick E Grobbee, and Huibert Burger PMCID: PMC1626076 Fracture risk and the use of a diuretic (indapamide sr) ± perindopril: a substudy of the Hypertension in the Very Elderly Trial (HYVET) Christopher J Bulpitt, Ruth Peters, Jan A Staessen, Lutgarde Thijs, Marie-Christine De Vernejoul, Astrid E Fletcher, and Nigel S Beckett PMCID: PMC1769508 |
