National Cancer Institute Center for Bioinformatics (NCICB) projects build on
our core infrastructure, tools, and services to fulfill the needs of specific
research communities. Within each project, participants collaborate in
developing and/or adopting informatics components that provide innovative ways
to integrate data and share new findings. These components can be used by others
working in the given research area, and many have broader utility to researchers
outside the cancer community. Specific tools may be found in the Tools and Downloads sections
of this Web site.
|
|
caAdapter
caAdapter is an open source tool set that provides model mapping services in support of caCORE components and facilitates data mapping and transformation among different kinds of data sources including HL7 v2 messages, HL7 v3 messages, and Regulatory Data Sets.
caAdapter has a component-based architecture to support message development and reporting using standard data formats. It also integrates with other clinical trials applications such as caXchange. caAdapter provides web service access and APIs for easy application integration.
|
|
|
|
|
|
caBIG™
The cancer Biomedical Informatics Grid? or caBIG? is a
voluntary network or grid connecting individuals and institutions to
enable the sharing of data and tools, creating a World Wide Web of
cancer research. Activities cover clinical trials management
systems, tissue banks and pathology tools, integrated cancer
research, architecture, vocabularies and common data elements, data
sharing and intellectual capital. The infrastructure and tools
created by caBIG?also have broad utility outside the cancer
community. Currently, 50 NCI-designated cancer centers and 30 other
organizations—over 600 individuals in all—are engaged in caBIG?
under the leadership of the National Cancer Institute's Center for
Bioinformatics. |
|
|
|
|
|
Cancer Gene Data Curation Project
The Cancer Gene Data Curation Project is an attempt to create a database of associations between genes and diseases and genes and drug compounds derived from the biomedical literature. The project involves a mixture of automatic text mining, semi-automatic verification, and manual validation/scoring of results. A pilot study involving 1000 genese was completed in March 2005 by the NCICB, ScenPro, and Biomax Solutions, Inc. The next phase of this study began on 20-Sep-2005, and will involve the curation of 1500 additional genes by early 2006. |
|
|
|
|
|
National Cancer Imaging Archive (NCIA)
The in vivo image repository provides the cancer research community, industry, and academia with access to image archives that
can be used for many purposes including the potential to assist in the development and validation of analytical software tools
supporting: lesion detection and classification software, accelerated diagnostic imaging decision, and quantitative imaging
assessment of drug response. The repository provides access to imaging resources that will improve the use of imaging in today's
cancer research and practice by: increasing the efficiency and reproducibility of imaging cancer detection and diagnosis, leveraging
imaging to provide an objective assessment of therapeutic response, and ultimately enabling the development of imaging resources that
will lead to improved clinical decision support. |
|
|
|
|
|
I-SPY
The I-SPY project is a national study that uses imaging and
molecular analysis to predict treatment response to breast cancer
therapy. The I-SPY team is collecting, analyzing, and sharing
diverse genomic and clinical data across organizations. The goal of
this project is to identify and integrate treatment response
biomarkers for analysis in support of translational research. |
|
|
|
|
|
Mouse Models
The NCI Mouse Models of Human Cancers Consortium (MMHCC) is a
collaborative program to derive, characterize, and validate mouse
models of human cancers and to make these models available to
researchers who engage in basic, translational, clinical, or
epidemiological investigations using mice. |
|
|
|
|
|
REMBRANDT
The purpose of the REpository of Molecular BRAin Neoplasia DaTa
(REMBRANDT) project is to provide an open and accessible portal for
a national molecular, genetic, and clinical database of several
thousand primary brain tumors (including gliomas). REMBRANDT is a
bioinformatics knowledgebase that uses data warehousing technology
to host and integrate molecular research and clinical trials data
related to brain cancers. This comprehensive information repository
provides researchers the ability to perform ad hoc querying and
reporting across multiple data domains, including gene expression,
chromosomal aberrations, and clinical data. |
|
|
|
|
|
SpiderWeb
SpiderWeb is a network for sharing clinical and molecular
information across enterprises. It provides a standard method for
linking multiple databases by using common vocabulary, standards,
technology, and infrastructure—while at the same time maintaining
the security and confidentiality of patient information. SpiderWeb
gives researchers the ability to compare genomic and clinical
information across trials in order to diagnose genetic
predisposition, sub-classify diseases, select optimal therapies, and
design better diagnostics and therapeutics. |
|
|
|
|
|