Molecular Targets for Cancer Prevention Conference

Scientifc Program

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Molecular Targets for Cancer Prevention Conference
Natcher Auditorium, NIH
February 4-5, 2009

Organizing Committee: Bill Farrar and Nancy Colburn LCP, CCR; Co-Chairs, Pat Steeg, Terry Van Dyke, Sheila Prindiville, John Milner, and Leslie Ford

The purpose of this two-day small conference is to bring together leaders in cancer prevention research from the CCR/NCI and the extramural community to respond to new opportunities for discovery that can advance the field in three major areas of investigation as outlined below. All sessions include both preclinical and clinical studies as well as molecular targeted approaches. Unique to this conference are Round Tables that focus on interactive mouse-human studies that are needed to move toward individualized prevention.

February 4, 2009

8:00	Coffee and Continental Breakfast
8:30	Welcome: Bob Wiltrout, Director CCR, NCI; Peter Greenwald, Director, DCP, NCI
8:45	Speaker — Scott Lippman, University of Texas, M.D. Anderson Cancer Center and Editor, Cancer Prevention Research - "Molecular Targeting and the Prevention - Therapy Convergence"
9:30	Molecular Targeted Therapeutics in the CCR, Patricia Steeg, NCI
9:55	Targeting Transcription Factors— Chair: Tom Kensler, Johns Hopkins University; Co-Chair: Sheila Prindiville, CCR, NCI
10:00	Tom Kensler, Johns Hopkins University - "Keap1-Nrf2 Signaling as a Target for Chemoprevention"
10:25	Powel Brown, Baylor University — "Translational Cancer Prevention Studies: Developing Novel Agents for the Prevention of Breast Cancer"
10:50	Bill Farrar, CCR, NCI - "Targeting Prostate Cancer Stem Cells"
11:15	Marsten Linehan, CCR, NCI - "Genetic Basis of Kidney Cancer: Opportunity for Disease Based Therapy"
11:40	Nancy Colburn, CCR, NCI — "Targeting AP-1 and NFkB for Cancer Prevention"
12:05	Robert Glazer, Georgetown University — "Sca-1 is a Determinant of the Proliferative and Tumorigenic Potential of the Mammary Gland Downstream of PI3K, PDK1 and PPAR-delta Signaling"
12:20	Lunch and Poster Session
1:25	The Cancer Preclinical Mouse Models Initiative, Terry Van Dyke, CCR
1:40	PI3K/Akt/mTOR and Bioenergetics as Targets — Chair: Terry Van Dyke, Director Mouse Cancer Genetics Program, CCR, NCI; Co-Chair: Phil Dennis, CCR, NCI
1:45	Cory Abate-Shen, Columbia University - "Mouse models for studying Prostate Cancer Prevention"
2:10	Phil Dennis, CCR, NCI — "Mechanisms of Prevention of Lung Tumorigenesis by Rapamycin"
2:35	Zigang Dong, University of Minnesota/Hormel Institute - "Molecular targets for prevention of skin cancer"
3:00	Michael Pollack, McGill University - "Metformin, Insulin, and Cancer Prevention"
3:25	Craig Thompson, University of Penn - "The use of AMPK activators in cancer prevention and treatment"
3:50	Beverly Mock, CCR, NCI - "The Role of mTOR in B Cell Neoplasia"
4:15	Round Table on Molecular Targets and Mouse Models — Co-Chairs: Pat Steeg, CCR, NCI, Terry Van Dyke, CCR, NCI and Ron Lubet, DCP, NCI, Karlyne Reilly, CCR, NCI, Shyam Sharan, CCR, NCI, Jim McMahon, CCR, NCI and Speakers
5:30	Conclusion

February 5, 2009

8:00	Coffee and Continental Breakfast
8:30	Opening Speaker: Doug Lowy, CCR, NCI - "Oncogenic infectious agents as molecular targets for cancer prevention: the HPV vaccine"
8:55	Clinical Prevention Trials at the NCI, Eva Szabo, DCP, NCI
9:10	Oxidant Stress and Inflammation - Chair: David Wink, CCR, NCI; Co-Chair: Eva Szabo, DCP, NCI
9:15	Andrew Dannenberg, Cornell Weill - "The Prostaglandin-Aromatase Connection: Implications for Breast Carcinogenesis"
9:40	William Nelson, Johns Hopkins University – "Inflammation and DNA Methylation in the Pathogenesis of Prostate Cancer"
10:05	Jeff Green, CCR, NCI - "Can we prevent dormant tumor cells from awakening?"
10:30	David Wink, CCR, NCI – "The Role of Nitric Oxide and Other Small Molecules in Cancer"
11:05	Dolph Hatfield, CCR, NCI - "Role of Selenium in Cancer Prevention"
11:30	Yihong Ye, LMB, NIDDK – "ER stress, epigenetics, and cancer therapy: a new twist of an old tale "
11:45	Lunch
	Oxidant Stress and Inflammation (cont)
12:30	Larry Marnett, Vanderbilt University – "Exploiting Molecular Targets: Imaging of COX-2 in Inflammatory Lesions and Tumors"
12:55	Glenn Merlino, CCR, NCI - "Mice, melanoma and preclinical modeling"
1:20	Ming You, Wash University – "Chemoprevention of Lung Cancer Using Chemically Induced Mouse Models"
1:45	Dr. Ron Lubet, DCP, NCI – "Preclinical Screening Of NSAIDS And Celecoxib In A Carcinogen Induced Rat Bladder Model: Some Personal Observations."
2:00	Round Table on Interventions: How can mouse studies best inform human prevention trials and how can human studies be improved - Co-Chairs: Eva Szabo DCP, NCI, Jeff Green, Leslie Ford, DCP, NCI, John Milner, DCP, NCI, Sheila Prindiville, OD, NCI, Lynn Matrisian, Vanderbilt University, Howard Parnes, DCP, NCI, and Speakers
3:30	Conclusion