Our Science – Khan Website

Javed Khan, M.D.

Selected Publications

1) Bilke S, Chen QR, Wei JS, Khan J.
Whole chromosome alterations predict survival in high-risk neuroblastoma without MYCN amplification.
Clin. Cancer Res. 14: 5540-7, 2008. [Journal]

2) Chen QR, Song YK, Wei JS, Bilke S, Asgharzadeh S, Seeger RC, Khan J.
An integrated cross-platform prognosis study on neuroblastoma patients.
Genomics. 2008. [Journal]

3) Alabran JL, Cheuk A, Liby K, Sporn M, Khan J, Letterio J, Leskov KS.
Human Neuroblastoma Cells Rapidly Enter Cell Cycle Arrest and Apoptosis Following Exposure to C-28 derivatives of the Synthetic Triterpenoid CDDO.
Cancer Biol. Ther. 7, 2008. [Journal]

4) Neale G, Su X, Morton CL, Phelps D, Gorlick R, Lock RB, Reynolds CP, Maris JM, Friedman HS, Dome J, Khoury J, Triche TJ, Seeger RC, Gilbertson R, Khan J, Smith MA, Houghton PJ.
Molecular characterization of the pediatric preclinical testing panel.
Clin. Cancer Res. 14: 4572-83, 2008. [Journal]

5) Kowalska A, Brunner B, Bozsaky E, Chen Q, Stock C, Lorch T, Khan J, Ambros PF.
Sequence based high resolution chromosomal CGH.
Cytogenet. Genome Res. 121: 1-6, 2008. [Journal]

6) Wei JS, Song YK, Durinck S, Chen QR, Cheuk AT, Tsang P, Zhang Q, Thiele CJ, Slack A, Shohet J, Khan J.
The MYCN oncogene is a direct target of miR-34a.
Oncogene. 2008. [Journal]

7) Bilke S, Khan J.
Analysis of comparative genomic hybridization data on cDNA microarrays.
Methods Mol. Biol. 377: 175-86, 2007. [Journal]

8) Whiteford CC, Bilke S, Greer BT, Chen Q, Braunschweig TA, Cenacchi N, Wei JS, Smith MA, Houghton P, Morton C, Reynolds CP, Lock R, Gorlick R, Khanna C, Thiele CJ, Takikita M, Catchpoole D, Hewitt SM, Khan J.
Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis.
Cancer Res. 67: 32-40, 2007. [Journal]

9) Chen QR, Vansant G, Oades K, Pickering M, Wei JS, Song YK, Monforte J, Khan J.
Diagnosis of the small round blue cell tumors using multiplex polymerase chain reaction.
The Journal of molecular diagnostics : JMD. 9: 80-8, 2007. [Journal]

10) Catchpoole D, Lail A, Guo D, Chen Q, Khan J.
Gene expression profiles that segregate patients with childhood acute lymphoblastic leukaemia: An independent validation study identifies that endoglin associates with patient outcome.
Leuk Res. 31(12): 1741-7, 2007. [Journal]

11) Westermann F, Henrich KO, Wei JS, Lutz W, Fischer M, König R, Wiedemeyer R, Ehemann V, Brors B, Ernestus K, Leuschner I, Benner A, Khan J, Schwab M.
High Skp2 expression characterizes high-risk neuroblastomas independent of MYCN status.
Clin. Cancer Res. 13: 4695-703, 2007. [Journal]

12) Greer B, Khan J.
Online analysis of microarray data using artificial neural networks.
Methods Mol. Biol. 377: 61-74, 2007. [Journal]

13) Zheng J, Kohler ME, Chen Q, Weber J, Khan J, Johnson BD, Orentas RJ.
Serum from mice immunized in the context of Treg inhibition identifies DEK as a neuroblastoma tumor antigen.
BMC Immunol. 8: 4, 2007. [Journal]

14) Chen Q, Bilke S, Wei JS, Greer BT, Steinberg SM, Westermann F, Schwab M, Khan J.
Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma.
Genes Chromosomes Cancer. 45(9): 856-62, 2006. [Journal]

15) Henrich KO, Fischer M, Mertens D, Benner A, Wiedemeyer R, Brors B, Oberthuer A, Berthold F, Wei JS, Khan J, Schwab M, Westermann F.
Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients.
Clin. Cancer Res. 12: 131-8, 2006. [Journal]

16) Houghton PJ, Morton CL, Tucker C, Payne D, Favours E, Cole C, Gorlick R, Kolb EA, Zhang W, Lock R, Carol H, Tajbakhsh M, Reynolds CP, Maris JM, Courtright J, Keir ST, Friedman HS, Stopford C, Zeidner J, Wu J, Liu T, Billups CA, Khan J, Ansher S, Zhang J, Smith MA.
The pediatric preclinical testing program: Description of models and early testing results.
Pediatr Blood Cancer. 49(7): 928-40, 2006. [Journal]

17) Krasnoselsky AL, Whiteford CC, Wei JS, Bilke S, Westermann F, Chen QR, Khan J.
Altered expression of cell cycle genes distinguishes aggressive neuroblastoma.
Oncogene. 24: 1533-41, 2005. [Journal]

18) Wei JS, Whiteford CC, Cenacchi N, Son CG, Khan J.
BBC3 mediates fenretinide-induced cell death in neuroblastoma.
Oncogene. 24(54): 7976-83, 2005. [Journal]

19) Son CG, Bilke S, Davis S, Greer BT, Wei JS, Whiteford CC, Chen QR, Cenacchi N, Khan J.
Database of mRNA gene expression profiles of multiple human organs.
Genome Res. 15: 443-50, 2005. [Journal]

20) Bilke S, Chen QR, Whiteford CC, Khan J.
Detection of low level genomic alterations by comparative genomic hybridization based on cDNA micro-arrays.
Bioinformatics. 21: 1138-45, 2005. [Journal]

21) Kim HS, Choi EH, Khan J, Roilides E, Francesconi A, Kasai M, Sein T, Schaufele RL, Sakurai K, Son CG, Greer BT, Chanock S, Lyman CA, Walsh TJ.
Expression of genes encoding innate host defense molecules in normal human monocytes in response to Candida albicans.
Infect Immun. 73: 3714-24, 2005. [Journal]

22) Jazaeri AA, Awtrey CS, Chandramouli GV, Chuang YE, Khan J, Sotiriou C, Aprelikova O, Yee CJ, Zorn KK, Birrer MJ, Barrett JC, Boyd J.
Gene expression profiles associated with response to chemotherapy in epithelial ovarian cancers.
Clin. Cancer Res. 11: 6300-10, 2005. [Journal]

23) Chen Q, Bilke S, Khan J.
High-resolution cDNA microarray-based comparative genomic hybridization analysis in neuroblastoma.
Cancer Lett. 228(1-2): 71-81, 2005. [Journal]

24) Bilke S, Chen QR, Westerman F, Schwab M, Catchpoole D, Khan J.
Inferring a tumor progression model for neuroblastoma from genomic data.
J. Clin. Oncol. 23: 7322-31, 2005. [Journal]

25) Umar A, Kapetanovic I, Khan J, eds.
The Applications of Bioinformatics in Cancer Detection. Volume 1020.
New York: The New York Academy of Sciences; 2004. [Book (Editor)]

26) Chen QR, Bilke S, Wei JS, Whiteford CC, Cenacchi N, Krasnoselsky AL, Greer BT, Son CG, Westermann F, Berthold F, Schwab M, Catchpoole D, Khan J.
cDNA array-CGH profiling identifies genomic alterations specific to stage and MYCN-amplification in neuroblastoma.
BMC Genomics. 70, 2004. [Journal]

27) Chen QR, Bilke S, Wei JS, Whiteford CC, Cenacchi N, Krasnoselsky AL, Greer BT, Son CG, Westermann F, Berthold F, Schwab M, Catchpoole D, Khan J.
cDNA array-CGH profiling identifies genomic alterations specific to stage and MYCN-amplification in neuroblastoma.
BMC Genomics. 5: 70, 2004. [Journal]

28) Greer BT, Khan J.
Diagnostic classification of cancer using DNA microarrays and artificial intelligence.
Ann N Y Acad Sci. 1020: 49-66, 2004. [Journal]

29) Greer BT, Khan J.
Diagnostic classification of cancer using DNA microarrays and artificial intelligence.
Ann N Y Acad Sci. 1020: 49-66, 2004. [Journal]

30) Yu Y, Khan J, Khanna C, Helman L, Meltzer PS, Merlino G.
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.
Nat Med. 10: 175-81, 2004. [Journal]

31) Wei JS, Greer BT, Westermann F, Steinberg SM, Son CG, Chen QR, Whiteford CC, Bilke S, Krasnoselsky AL, Cenacchi N, Catchpoole D, Berthold F, Schwab M, Khan J.
Prediction of clinical outcome using gene expression profiling and artificial neural networks for patients with neuroblastoma.
Cancer Res. 64: 6883-91, 2004. [Journal]

32) Kapetanovic IM, Umar A, Khan J.
Proceedings: the Applications of Bioinformatics in Cancer Detection Workshop.
Ann N Y Acad Sci. 1020: 1-9, 2004. [Journal]

33) Williams RD, Hing SN, Greer BT, Whiteford CC, Wei JS, Natrajan R, Kelsey A, Rogers S, Campbell C, Pritchard-Jones K, Khan J.
Prognostic classification of relapsing favorable histology Wilms tumor using cDNA microarray expression profiling and support vector machines.
Genes Chromosomes Cancer. Sep;41(1): 65-79, 2004. [Journal]

34) Desper R, Khan J, Schäffer AA.
Tumor classification using phylogenetic methods on expression data.
J Theor Biol. 228: 477-96, 2004. [Journal]

35) Bomprezzi R, Ringnér M, Kim S, Bittner ML, Khan J, Chen Y, Elkahloun A, Yu A, Bielekova B, Meltzer PS, Martin R, McFarland HF, Trent JM.
Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease.
Hum Mol Genet. 12: 2191-9, 2003. [Journal]

36) Khan J.
Genomic & proteomic technological advances in cancer research.
Pharmacogenomics. 4: 245-9, 2003. [Journal]

37) Ringnér M, Peterson C, Khan J.
Analyzing array data using supervised methods.
Pharmacogenomics. 3: 403-15, 2002. [Journal]

38) Dickens DS, Kozielski R, Khan J, Forus A, Cripe TP.
Cyclooxygenase-2 expression in pediatric sarcomas.
Pediatr Dev Pathol. 5: 356-64, 2002. [Journal]

39) Rice AM, Currier MA, Adams LC, Bharatan NS, Collins MH, Snyder JD, Khan J, Cripe TP.
Ewing sarcoma family of tumors express adenovirus receptors and are susceptible to adenovirus-mediated oncolysis.
J Pediatr Hematol Oncol. Oct;24(7): 527-33, 2002. [Journal]

40) Khan J, Saal LH, Bittner ML, Jiang Y, Gooden GC, Glatfelter AA, Meltzer PS.
Gene expression profiling in cancer using cDNA microarrays.
Methods Mol Med. 68: 205-22, 2002. [Journal]

41) Khan J, Wei JS, Ringnér M, Saal LH, Ladanyi M, Westermann F, Berthold F, Schwab M, Antonescu CR, Peterson C, Meltzer PS.
Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks.
Nat Med. 7: 673-9, 2001. [Journal]

42) Dupont J, Khan J, Qu BH, Metzler P, Helman L, LeRoith D.
Insulin and IGF-1 induce different patterns of gene expression in mouse fibroblast NIH-3T3 cells: identification by cDNA microarray analysis.
Endocrinology. 142: 4969-75, 2001. [Journal]

43) Khanna C, Khan J, Nguyen P, Prehn J, Caylor J, Yeung C, Trepel J, Meltzer P, Helman L.
Metastasis-associated differences in gene expression in a murine model of osteosarcoma.
Cancer Res. 61: 3750-9, 2001. [Journal]

44) Heiskanen MA, Bittner ML, Chen Y, Khan J, Adler KE, Trent JM, Meltzer PS.
Detection of gene amplification by genomic hybridization to cDNA microarrays.
Cancer Res. 60(4): 799-802, 2000. [Journal]

45) Khan J, Bittner ML, Saal LH, Teichmann U, Azorsa DO, Gooden GC, Pavan WJ, Trent JM, Meltzer PS.
cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene.
Proc Natl Acad Sci U S A. 96: 13264-9, 1999. [Journal]

46) Khan J, Bittner ML, Chen Y, Meltzer PS, Trent JM.
DNA microarray technology: the anticipated impact on the study of human disease.
Biochim Biophys Acta. 1423: M17-28, 1999. [Journal]

47) Khan J, Saal LH, Bittner ML, Chen Y, Trent JM, Meltzer PS.
Expression profiling in cancer using cDNA microarrays.
Electrophoresis. 20: 223-9, 1999. [Journal]

48) Khan J, Parsa NZ, Harada T, Meltzer PS, Carter NP.
Detection of gains and losses in 18 meningiomas by comparative genomic hybridization.
Cancer Genet Cytogenet. 103: 95-100, 1998. [Journal]

49) Khan J, Simon R, Bittner M, Chen Y, Leighton SB, Pohida T, Smith PD, Jiang Y, Gooden GC, Trent JM, Meltzer PS.
Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays.
Cancer Res. 58: 5009-13, 1998. [Journal]

50) Khan J, Broadbent VA.
Tumor lysis syndrome complicating treatment of widespread metastatic abdominal rhabdomyosarcoma.
Pediatr Hematol Oncol. 10: 151-5, 1993. [Journal]

51) Khan J, Greer B, Wei J, inventor; DHHS, assignee.
Selections Of Genes And Methods Using The Same For Diagnosis And For Trageting The Therapy Of Select Cancers.
Patent Pending, Filed in 2001. Application No. 60/598,728; 1/572,667. Pending [Patent]

This page was last updated on 11/21/2008.