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Our Science – Wang Website

Ji Ming Wang, M.D., Ph.D.

Selected Publications
1)  Yao XH, Ping YF, Chen JH, Xu CP, Chen DL, Zhang R, Wang J, Bian XW.
Glioblastoma stem cells produce vascular endothelial growth factor by activation of a G-protein coupled formylpeptide receptor FPR.
J. Pathol. 215: 369-76, 2008. [Journal]
2)  Meng XL, Yang JY, Chen GL, Zhang LJ, Wang LH, Li J, Wang JM, Wu CF.
RV09, a novel resveratrol analogue, inhibits NO and TNF-alpha production by LPS-activated microglia.
Int. Immunopharmacol. 8: 1074-82, 2008. [Journal]
3)  Chen K, Huang J, Gong W, Zhang L, Yu P, Wang JM.
CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system.
Cell. Mol. Immunol. 3: 163-9, 2006. [Journal]
4)  Wang J, inventor; DHHS, assignee.
Cathepsin G-related Peptides As Modulators Of Formylpeptide Receptors (fpr).
Patent Pending, Filed in 2003. Application No. 11/154,744. Pending [Patent]
5)  Chen K, Zhang L, Huang J, Gong W, Dunlop NM, Wang JM.
Cooperation between NOD2 and Toll-like receptor 2 ligands in the up-regulation of mouse mFPR2, a G-protein-coupled Abeta42 peptide receptor, in microglial cells.
J. Leukoc. Biol. 83: 1467-75, 2008. [Journal]
6)  Huang J, Chen K, Gong W, Dunlop NM, Wang JM.
G-protein coupled chemoattractant receptors and cancer.
Front. Biosci. 13: 3352-63, 2008. [Journal]
7)  Attal H, Cohen-Hillel E, Meshel T, Wang JM, Gong W, Ben-Baruch A.
Intracellular cross-talk between the GPCR CXCR1 and CXCR2: role of carboxyl terminus phosphorylation sites.
Exp. Cell Res. 314: 352-65, 2008. [Journal]
8)  Huang J, Chen K, Gong W, Zhou Y, Le Y, Bian X, Wang JM.
Receptor.
Cancer Lett. 267: 254-261, 2008. [Journal]
9)  Song C, Xiao Z, Nagashima K, Li CC, Lockett SJ, Dai RM, Cho EH, Conrads TP, Veenstra TD, Colburn NH, Wang Q, Wang JM.
The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation.
Toxicol. Appl. Pharmacol. 228: 351-63, 2008. [Journal]
10)  Iribarren P, Chen K, Gong W, Cho EH, Lockett S, Uranchimeg B, Wang JM.
Interleukin 10 and TNFalpha synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microglia.
Neurobiol Dis. 2007. [Journal]
11)  Huang J, Hu J, Bian X, Chen K, Gong W, Dunlop NM, Howard OM, Wang JM.
Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cells.
Cancer Res. 67: 5906-13, 2007. [Journal]
12)  Wang J, Chen K. Kastin A, eds.
Chemotactic peptide ligands for formylpeptide receptors influencing inflammation. In: The Handbook of Biologically Active Peptides. Volume .
London: Academic Press Elsevier; 2006. In Press. [Book Chapter]
13)  Bian X, Wang Q, Xiao H, Wang JM.
Tumor microvascular architecture phenotype (T-MAP) as a new concept for studies of angiogenesis and oncology.
J Neuro oncol. 2006. In Press. [Journal]
14)  Chen K, Iribarren P, Hu J, Chen J, Gong W, Cho EH, Lockett S, Dunlop NM, Wang JM.
Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide.
J. Biol. Chem. 281: 3651-9, 2006. [Journal]
15)  Bian XW, Jiang XF, Chen JH, Bai JS, Dai C, Wang QL, Lu JY, Zhao W, Xin R, Liu MY, Shi JQ, Wang JM.
Increased angiogenic capabilities of endothelial cells from microvessels of malignant human gliomas.
Int. Immunopharmacol. 6: 90-9, 2006. [Journal]
16)  Zhang N, Inan S, Inan S, Cowan A, Sun R, Wang JM, Rogers TJ, Caterina M, Oppenheim JJ.
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
Proc Natl Acad Sci U S A. 102: 4536-41, 2005. [Journal]
17)  Zhou Y, Bian X, Le Y, Gong W, Hu J, Zhang X, Wang L, Iribarren P, Salcedo R, Howard OM, Farrar W, Wang JM.
Formylpeptide receptor FPR and the rapid growth of malignant human gliomas.
J Natl Cancer Inst. 97: 823-35, 2005. [Journal]
18)  Le Y, Ye RD, Gong W, Li J, Iribarren P, Wang JM.
Identification of functional domains in the formyl peptide receptor-like 1 for agonist-induced cell chemotaxis.
FEBS J. 272: 769-78, 2005. [Journal]
19)  Iribarren P, Chen K, Hu J, Zhang X, Gong W, Wang JM.
IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microglia.
J. Immunol. 175: 6100-6, 2005. [Journal]
20)  Sun R, Gao P, Chen L, Ma D, Wang J, Oppenheim JJ, Zhang N.
Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.
Cancer Res. 65: 1433-41, 2005. [Journal]
21)  Iribarren P, Zhou Y, Hu J, Le Y, Wang JM.
Role of Formyl Peptide Receptor-Like 1 (FPRL1/FPR2) in Mononuclear Phagocyte Responses in Alzheimer Disease.
Immunol Res. 31: 165-76, 2005. [Journal]
22)  Chen KQ, Iribarren P, Gong WH, Wang JM.
The Essential Role of Phosphoinositide 3-Kinases (PI3Ks) in Regulating Pro-Inflammatory Responses and the Progression of Cancer.
Cellular & molecular immunology. 2: 241-52, 2005. [Journal]
23)  Le Y, Yu X, Ruan L, Wang O, Qi D, Zhu J, Lu X, Kong Y, Cai K, Pang S, Shi X, Wang JM.
The immunopharmacological properties of transforming growth factor beta.
Int. Immunopharmacol. 5: 1771-82, 2005. [Journal]
24)  Hu J, Li G, Tong Y, Li Y, Zhou G, He X, Xie P, Wang JM, Sun Q.
Transduction of the gene coding for a human G-protein coupled receptor FPRL1 in mouse tumor cells increases host anti-tumor immunity.
Int Immunopharmacol. 5: 971-80, 2005. [Journal]
25)  Finnegan CM, Rawat SS, Puri A, Wang JM, Ruscetti FW, Blumenthal R.
Ceramide, a target for antiretroviral therapy.
Proc Natl Acad Sci U S A. 101: 15452-7, 2004. [Journal]
26)  Biragyn A, Ruffini PA, Coscia M, Harvey LK, Neelapu SS, Baskar S, Wang JM, Kwak LW.
Chemokine receptor-mediated delivery directs self-tumor antigen efficiently into the class II processing pathway in vitro and induces protective immunity in vivo.
Blood. 104: 1961-1969, 2004. [Journal]
27)  Partida-Sánchez S, Iribarren P, Moreno-García ME, Gao JL, Murphy PM, Oppenheimer N, Wang JM, Lund FE.
Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP ribose.
J Immunol. 172: 1896-906, 2004. [Journal]
28)  Rawat SS, Gallo SA, Eaton J, Martin TD, Ablan S, KewalRamani VN, Wang JM, Blumenthal R, Puri A.
Elevated expression of GM3 in receptor-bearing targets confers resistance to human immunodeficiency virus type 1 fusion.
J Virol. 78: 7360-8, 2004. [Journal]
29)  Rawat SS, Eaton J, Gallo SA, Martin TD, Ablan S, Ratnayake S, Viard M, KewalRamani VN, Wang JM, Blumenthal R, Puri A.
Functional expression of CD4, CXCR4, and CCR5 in glycosphingolipid-deficient mouse melanoma GM95 cells and susceptibility to HIV-1 envelope glycoprotein-triggered membrane fusion.
Virology. 318: 55-65, 2004. [Journal]
30)  Ying G, Iribarren P, Zhou Y, Gong W, Zhang N, Yu ZX, Le Y, Cui Y, Wang JM.
Humanin, a newly identified neuroprotective factor, uses the G-protein-coupled receptor FPRL1 as a functional receptor.
J. Immunol. 172: 7078-85, 2004. [Journal]
31)  Sun R, Iribarren P, Zhang N, Zhou Y, Gong W, Cho EH, Lockett S, Chertov O, Bednar F, Rogers TJ, Oppenheim JJ, Wang JM.
Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor.
J Immunol. 173: 428-36, 2004. [Journal]
32)  Zhang X, Rodriguez-Galán MC, Subleski JJ, Ortaldo JR, Hodge DL, Wang JM, Shimozato O, Reynolds DA, Young HA.
Peroxisome Proliferator-activated Receptor-{gamma} and Its Ligands Attenuate Biological Functions of Human Natural Killer Cells.
Blood. 2004. [Journal]
33)  Le Y, Iribarren P, Zhou Y, Gong W, Hu J, Zhang X, Wang JM.
Silencing the formylpeptide receptor FPR by short-interfering RNA.
Mol Pharmacol. 66: 1022-1028, 2004. [Journal]
34)  Le Y, Iribarren P, Gong W, Cui Y, Zhang X, Wang JM.
TGF-beta1 disrupts endotoxin signaling in microglial cells through Smad3 and MAPK pathways.
J Immunol. 173: 962-8, 2004. [Journal]
35)  Grimm MC, Newman R, Hassim Z, Cuan N, Connor SJ, Le Y, Wang JM, Oppenheim JJ, Lloyd AR.
Cutting edge: vasoactive intestinal peptide acts as a potent suppressor of inflammation in vivo by trans-deactivating chemokine receptors.
J Immunol. 171: 4990-4994, 2003. [Journal]
36)  Iribarren P, Cui YH, Le Y, Ying G, Zhang X, Gong W, Wang JM.
IL-4 down-regulates lipopolysaccharide-induced formyl peptide receptor 2 in murine microglial cells by inhibiting the activation of mitogen-activated protein kinases.
J Immunol. 171: 5482-5488, 2003. [Journal]
37)  Le Y, Cui Y, Ying G, Iribarren P, Wang JM.
The role of chemokine receptors in the promotion of viral infections.
Contrib Microbiol. 10: 210-231, 2003. [Journal]
38)  Cui YH, Le Y, Gong W, Proost P, Van Damme J, Murphy WJ, Wang JM.
Bacterial lipopolysaccharide selectively up-regulates the function of the chemotactic peptide receptor FPR2 in murine microglial cells.
J. Immunol. 168: 434-442, 2002. [Journal]
39)  Le Y, Murphy PM, Wang JM.
Formyl peptide receptors revisited.
Trends Immunol. 23: 541-548, 2002. [Journal]
40)  Hodge DL, Schill WB, Wang JM, Blanca I, Reynolds DA, Ortaldo JR, Young HA.
IL-2 and IL-12 alter natural killer cell responsiveness to IP-10 by downregulating CXCR3 expression.
J. Immunol. 168: 6090-6098, 2002. [Journal]
41)  Le Y, Cui Y, Iribarren P, Ying G, Wang JM.
Manipulating chemoattractant and receptor genes.
In Vivo. 16: 1-24, 2002. [Journal]
42)  Cui Y, Le Y, Yazawa H, Gong W, Wang JM.
Potential role of the formyl peptide receptor-like 1 (FPRL1) in inflammatory aspects of Alzheimer's disease.
J. Leuk. Biol. 72: 628-635, 2002. [Journal]
43)  Le Y, Yang Y, Cui Y, Yazawa H, Gong W, Qiu C, Wang JM.
Receptors for chemotactic formyl peptides as pharmacological targets.
Internal. Immunopharm. 1: 1-13, 2002. [Journal]
44)  Viard M, Parolini I, Sargiacomo M, Fecchi K, Ramoni C, Ablan S, Ruscetti FW, Wang JM, Blumenthal R.
Role of cholesterol in human immunodeficiency virus type 1 envelope protein-mediated fusion with host cells.
J Virol. 76: 11584-95, 2002. [Journal]
45)  Menten P, Saccani A, Dillen C, Wuyts A, Struyf S, Proost P, Mantovani A, Wang JM, Van Damme J.
Role of the autocrine chemokines MIP-1alpha and MIP-1beta in the metastatic behavior of murine T cell lymphoma.
J Leukoc Biol. 72: 780-9, 2002. [Journal]
46)  Resnati M, Pallavicini I, Wang JM, Oppenheim J, Serhan CN, Romano M, Blasi F.
The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.
PNAS. 99: 1359-1364, 2002. [Journal]
47)  Iribarren P, Cui YH, Le Y, Wang JM.
The role of dendritic cells in neurodegenerative diseases.
Arch. Imm. et Ter. Exp. 50: 187-196, 2002. [Journal]
48)  Cui YH, Le Y, Zhang X, Gong W, Abe K, Sun R, Van Damme J, Proost P, Wang JM.
Up-regulation of FPR2, a chemotactic receptor for amyloid beta 1-42 (A beta 42), in murine microglial cells by TNF alpha.
Neurobiol. Dis. 10: 366-377, 2002. [Journal]
49)  Braun MC, Wang JM, Lahey E, Rabin RL, Kelsall BL.
Activation of chemotactic receptor FPR by HIV derived peptides suppresses IL-12p70 production by human monocytes.
Blood. 97: 3531-3536, 2001. [Journal]
50)  Le Y, Gong W, Tiffany HL, Tumanov A, Nedospasov S, Shen W, Dunlop NM, Gao JL, Murphy PM, Oppenheim JJ, Wang JM.
Amyloid beta 42 activates a G protein-coupled chemoattractant receptor FPRL1.
J. Neurosci. 21: RC123, 2001. [Journal]
51)  Tiffany HL, Lavigne MC, Cui YH, Wang JM, Leto TL, Gao JL, Murphy PM.
Amyloid-beta induces chemotaxis and oxidant stress by acting at formyl peptide receptor 2 (FPR2), a G protein-coupled receptor expressed in phagocytes and brain.
J. Biol. Chem. 276: 23275-23281, 2001. [Journal]
52)  Yazawa H, Yu ZX, Takeda , Le Y, Gong W, Ferrans VJ, Oppenheim JJ, Li CC, Wang JM.
BEta Amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.
FASEB J. 15: 2454-2462, 2001. [Journal]
53)  Le Y, Wetzel MA, Shen W, Gong W, Rogers TJ, Henderson EE, Wang JM.
Desensitization of chemokine receptor CCR5 in dendritic cells at the early stage of differentiation by activation of formyl peptide receptors.
Clin. Immunol. 99: 365-372, 2001. [Journal]
54)  Zhang X, Wang JM, Gong HG, Mukaida N, Young HA.
Differential regulation of chemokine gene expression by 15-deoxy- (trinagle)12,14 Prostaglandin J2.
J. Immunol. 166: 7104-7111, 2001. [Journal]
55)  Yang D, Chen Q, Le Y, Wang JM, Oppenheim JJ.
Differential regulation of formyl peptide receptor-like 1 (FPRL1) expression during the differentiation of monocytes to dendritic cells and macrophages.
J. Immunol. 166: 4092-4098, 2001. [Journal]
56)  Yamashiro S, Kamohara H, Wang JM, Yang D, Gong WH, Yoshimura T.
Phenotypic and functional change of cytokine-activated neutrophils: Inflammatory neutrophils are heterogeneous and enhance adaptive immune responses.
J. Leuk. Biol. 69: 698-704, 2001. [Journal]
57)  Le Y, Oppenheim JJ, Wang JM.
Pleiotropic roles of formyl peptide receptors.
Cytokine & Growth Fac. Rev. 12: 91-105, 2001. [Journal]
58)  Park JW, Gruys ME, McCormick K, Lee JK, Subleski J, Wigginton JM, Fenton RG, Wang JM, Wiltrout RH.
Primary hepatocytes from mice treated with IL-2/IL-12 produce T cell chemoattractant activity that is dependent on monokine induced by IFN-gamma (mig) and chemokine responsive to gamma-2 (crg-2).
J. Immunol. 166: 3763-3770, 2001. [Journal]
59)  Le Y, Yazawa H, Gong W, Yu Z, Ferrans VJ, Murphy PM, Wang JM.
The neurotoxic prion peptide fragment PrP106-126 is a chemotactic agonist for the G protein-coupled receptor FPRL1.
J. Immunol. 166: 1448-1451, 2001. [Journal]
60)  Tani K, Murphy WJ, Chertov O, Oppenheim JJ, Wang JM.
The neutrophil granule protein cathespin G activates murine T lymphocytes and upregulates antigen-specific Ig production in mice.
BBRC. 282: 971-976, 2001. [Journal]
61)  Hu JY, Le Y, Gong W, Dunlop NM, Gao JL, Murphy PM, Wang JM.
The synthetic peptide MMK-1 derived from a random peptide library is a highly specific chemotactic agonist for the leukocyte receptor FPRL1.
J. Leuk Biol. 70: 155-161, 2001. [Journal]
62)  Li BQ, Wetzel MA, Mikovits JA, Henderson EE, Rogers TJ, Gong W, Le Y, Ruscetti FW, Wang JM.
The synthetic peptide WKYMVm attenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of the formyl peptide receptor like 1.
Blood. 97: 2941-2947, 2001. [Journal]
63)  Wang JM, Le YY, Gong W, Yazawa H, Yu ZX, Oppenheim J, Murphy P, inventor; DHHS, assignee.
Identification of receptors mediating the proinflammatory activity of amyloid beta.
Patent Pending. Pending [Patent]
64)  Wang JM, Le YY, Oppenhiem J, Gong W, Li B, Murphy P, Rogers T, inventor.
Ligands for FPR class receptors that induce a host immune response to a pathogen or inhibit HIV.
US Patent: 6,808,877. 2004. [Patent]
65)  Oppenheim J, Wang JM, Gong W, Gao J, Murphy P, inventor.
T20/DP178 an activator of human phagoctye.
US Patent: 6,830,893. 2004. [Patent]

This page was last updated on 11/24/2008.