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Our Science – McMahon Website

James B. McMahon, Ph.D.

Selected Publications
1)  Sasiela CA, Stewart DH, Kitagaki J, Safiran YJ, Yang Y, Weissman AM, Oberoi P, Davydov IV, Goncharova E, Beutler JA, McMahon JB, O'Keefe BR.
Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 13: 229-37, 2008. [Journal]
2)  Marchand C, Beutler JA, Wamiru A, Budihas S, Möllmann U, Heinisch L, Mellors JW, Le Grice SF, Pommier Y.
Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H.
Antimicrob. Agents Chemother. 52: 361-4, 2008. [Journal]
3)  Dat NT, Bae K, Wamiru A, McMahon JB, Le Grice SF, Bona M, Beutler JA, Kim YH.
A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H.
J. Nat. Prod. 70: 839-41, 2007. [Journal]
4)  Ruocco KM, Goncharova EI, Young MR, Colburn NH, McMahon JB, Henrich CJ.
A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 12: 133-9, 2007. [Journal]
5)  Fromme R, Katiliene Z, Giomarelli B, Bogani F, Mc Mahon J, Mori T, Fromme P, Ghirlanda G.
A monovalent mutant of cyanovirin-N provides insight into the role of multiple interactions with gp120 for antiviral activity.
Biochemistry. 46: 9199-207, 2007. [Journal]
6)  Takada K, Bermingham A, O'Keefe BR, Wamiru A, Beutler JA, Le Grice SF, Lloyd J, Gustafson KR, McMahon JB.
An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis.
J. Nat. Prod. 70: 1647-9, 2007. [Journal]
7)  Meragelman TL, Willis RH, Woldemichael GM, Heaton A, Murphy PT, Snader KM, Newman DJ, van Soest R, Boyd MR, Cardellina JH, McKee TC.
Candidaspongiolides, distinctive analogues of tedanolide from sponges of the genus Candidaspongia.
J. Nat. Prod. 70: 1133-8, 2007. [Journal]
8)  Ziólkowska NE, Shenoy SR, O'Keefe BR, McMahon JB, Palmer KE, Dwek RA, Wormald MR, Wlodawer A.
Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin.
Proteins. 67: 661-70, 2007. [Journal]
9)  Emau P, Tian B, O'keefe BR, Mori T, McMahon JB, Palmer KE, Jiang Y, Bekele G, Tsai CC.
Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide.
J. Med. Primatol. 36: 244-53, 2007. [Journal]
10)  Giomarelli B, Washington VA, Chisholm MM, Quigley L, McMahon JB, Mori T, McVicar DW.
Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1.
Thromb. Haemost. 97: 955-63, 2007. [Journal]
11)  Yang Y, Kitagaki J, Dai RM, Tsai YC, Lorick KL, Ludwig RL, Pierre SA, Jensen JP, Davydov IV, Oberoi P, Li CC, Kenten JH, Beutler JA, Vousden KH, Weissman AM.
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.
Cancer Res. 67: 9472-81, 2007. [Journal]
12)  Henrich CJ, Goncharova EI, Wilson JA, Gardella RS, Johnson TR, McMahon JB, Takada K, Bokesch HR, Gustafson KR.
Natural products active in aberrant c-Kit signaling.
Chemical biology & drug design. 69: 321-30, 2007. [Journal]
13)  Henrich CJ, Robey RW, Bokesch HR, Bates SE, Shukla S, Ambudkar SV, Dean M, McMahon JB.
New inhibitors of ABCG2 identified by high-throughput screening.
Mol. Cancer Ther. 6: 3271-8, 2007. [Journal]
14)  Krumpe L, Mori T.
Potential of peptide library technology to identify functional targeting peptides.
Expert Opinion on Drug Discovery. 2: 525-537, 2007. [Journal]
15)  McFeeters RL, Xiong C, O'Keefe BR, Bokesch HR, McMahon JB, Ratner DM, Castelli R, Seeberger PH, Byrd RA.
The novel fold of scytovirin reveals a new twist for antiviral entry inhibitors.
J. Mol. Biol. 369: 451-61, 2007. [Journal]
16)  Mente NR, Wiemer AJ, Neighbors JD, Beutler JA, Hohl RJ, Wiemer DF.
Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.
Bioorg. Med. Chem. Lett. 17: 911-5, 2007. [Journal]
17)  Krumpe LR, Schumacher KM, McMahon JB, Makowski L, Mori T.
Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library.
BMC Biotechnol. 7: 65, 2007. [Journal]
18)  Henrich CJ, Bokesch HR, Dean M, Bates SE, Robey RW, Goncharova EI, Wilson JA, McMahon JB.
A high-throughput cell-based assay for inhibitors of ABCG2 activity.
J Biomol Screen. 11: 176-83, 2006. Full Text Article. [Journal]
19)  Kim YH, Park EJ, Park MH, Badarch U, Woldemichael GM, Beutler JA.
Crinamine from Crinum asiaticum var. japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2.
Biol. Pharm. Bull. 29: 2140-2, 2006. [Journal]
20)  Helle F, Wychowski C, Vu-Dac N, Gustafson KR, Voisset C, Dubuisson J.
Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans.
J. Biol. Chem. 281: 25177-83, 2006. [Journal]
21)  Woldemichael GM, Vasselli JR, Gardella RS, McKee TC, Linehan WM, McMahon JB.
Development of a cell-based reporter assay for screening of inhibitors of hypoxia-inducible factor 2-induced gene expression.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening. 11: 678-87, 2006. [Journal]
22)  Ziólkowska NE, O'keefe BR, Mori T, Zhu C, Giomarelli B, Vojdani F, Palmer KE, McMahon JB, Wlodawer A.
Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding.
Structure. 14: 1127-35, 2006. [Journal]
23)  Martinez ED, Dull AB, Beutler JA, Hager GL.
High-content fluorescence-based screening for epigenetic modulators.
Meth. Enzymol. 414: 21-36, 2006. [Journal]
24)  Liang MC, Bardhan S, Pace EA, Rosman D, Beutler JA, Porco JA, Gilmore TD.
Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.
Biochem. Pharmacol. 71: 634-45, 2006. [Journal]
25)  Sakamoto K, Ito Y, Mori T, Sugimura K.
Interaction of human lactoferrin with cell adhesion molecules through RGD motif elucidated by lactoferrin-binding epitopes.
J. Biol. Chem. 281: 24472-8, 2006. [Journal]
26)  Xiong C, O'Keefe BR, Byrd RA, McMahon JB.
Potent anti-HIV activity of scytovirin domain 1 peptide.
Peptides. 27: 1668-75, 2006. [Journal]
27)  Giomarelli B, Schumacher KM, Taylor TE, Sowder RC, Hartley JL, McMahon JB, Mori T.
Recombinant production of anti-HIV protein, griffithsin, by auto-induction in a fermentor culture.
Protein Expr. Purif. 47: 194-202, 2006. [Journal]
28)  Neighbors JD, Salnikova MS, Beutler JA, Wiemer DF.
Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity.
Bioorg. Med. Chem. 14: 1771-84, 2006. [Journal]
29)  Krumpe LR, Atkinson AJ, Smythers GW, Kandel A, Schumacher KM, McMahon JB, Makowski L, Mori T.
T7 lytic phage-displayed peptide libraries exhibit less sequence bias than M13 filamentous phage-displayed peptide libraries.
Proteomics. 6: 4210-22, 2006. [Journal]
30)  Mori T, Giomarelli B, McMahon J, Mcvicar D, Washington A, inventor; DHHS, assignee.
Isolation Of Human Anti-tlt-1 Antibody Fragments (single Chain Fvs) Recognizing Both Human And Murine Tlt-1 Extracellular Domain Of Phage Displayed Human Scfv Library With The Apparent Ablility To Suppress Thrombin-induced Platelet Aggregation In Vitro.
Patent Pending, Filed in 2006. Application No. 11/634,331. Pending [Patent]
31)  O'Keefe B, Byrd R, McMahon J, Xiong C, inventor; DHHS, assignee.
Scytovirin Domain 1 (sd1), An Antiviral Protein.
Patent Pending, Filed in 2005. Application No. 11/914,833. Pending [Patent]

This page was last updated on 11/24/2008.