Summaries & Associations of Study Results
TR-347 d-Limonene
Target Organs and Levels of Evidence
NTP Technical Report Number 347
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| D-LIMONENE 5989-27-5 |
04/18/88 | INDUSTRIAL SOLVENT, FLAVOR & FRAGRANCE ADDITIVE OBTAINED FROM CITRUS FRUIT | Gavage FR: 0,300,600, MR: 0,75,150, FM: 0,500,1000, MM: 0,250,500 MG/KG/50 PER GROUP | Microbiological Associates |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | KIDNEY TUBULAR CELL: ADENOMA 0/50 4/50 8/50 OR ADENOCARCINOMA 0/50 4/50 3/50 | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: PAPILLA, MINERALIZATION 7/50 43/50 48/50; HYPERPLASIA, TUBULAR CELL 0/50 4/50 7/50; HYPERPLASIA, EPITHELIAL 0/50 35/50 43/50; INCREASED SEVERITY OF NEPHROPATHY | |||
| FR: NO EVIDENCE | ||||
| MM: NO EVIDENCE | ||||
| FM: NO EVIDENCE | ||||
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