Testing Information

Testing Status of Agents at NTP

D-Limonene

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http://ntp.niehs.nih.gov/go/TS-10071-T

CASRN: 5989-27-5

Formula: C10-H16

Synonyms/Common Names:

  • (R)-1-METHYL-4-(1-METHYLETHENYL)-CYCLOHEXENE (9CI)

Known Uses:

INDUSTRIAL SOLVENT, FLAVOR & FRAGRANCE ADDITIVE OBTAINED FROM CITRUS FRUIT

Short-Term Toxicity

  • 14-Day (Gavage)  (C55572) Completed 
    • NTIS No. PB90-231416  (Peer Review 04/18/1988)
      Citation: Toxicology and Carcinogenesis Studies of d-Limonene (CAS No. 5989-27-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55572) Completed 
    • NTIS No. PB90-231416  (Peer Review 04/18/1988)
      Citation: Toxicology and Carcinogenesis Studies of d-Limonene (CAS No. 5989-27-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,150,2400, M: 0,125,2000 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C55572) Report Complete 
    • TR-347 (NTIS No. PB90-231416)  (Peer Review 04/18/1988)
      Toxicology and Carcinogenesis Studies of d-Limonene (CAS No. 5989-27-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: FR: 0,300,600, MR: 0,75,150, FM: 0,500,1000, MM: 0,250,500 MG/KG/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (269844) Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Mouse Lymphoma  (861341) Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    •  Negative 
  • Salmonella  (554149) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

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Web page last updated on January 22, 2009